8VFN
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![BU of 8vfn by Molmil](/molmil-images/mine/8vfn) | Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 310K | 分子名称: | D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-21 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VFL
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![BU of 8vfl by Molmil](/molmil-images/mine/8vfl) | Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 290K | 分子名称: | D-dopachrome decarboxylase | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-21 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VFK
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![BU of 8vfk by Molmil](/molmil-images/mine/8vfk) | Crystal Structure of Delta 109-117 D-Dopachrome Tautomerase (D-DT) | 分子名称: | CITRATE ANION, D-dopachrome decarboxylase, SODIUM ION | 著者 | Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. | 登録日 | 2023-12-21 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
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8VFJ
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![BU of 8vfj by Molmil](/molmil-images/mine/8vfj) | Polymerase Beta Host Guest Complex Containing FapydG base paired with TMP | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*(FAP)P*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*TP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFI
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![BU of 8vfi by Molmil](/molmil-images/mine/8vfi) | Ternary DNA Polymerase Beta bound to DNA containing primer terminal FapydG base-paired with a dA | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFH
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![BU of 8vfh by Molmil](/molmil-images/mine/8vfh) | Ternary DNA Polymerase Beta bound to DNA containing primer terminal FapydG base-paired with a dC | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(FAP))-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFG
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![BU of 8vfg by Molmil](/molmil-images/mine/8vfg) | Binary DNA Polymerase Beta bound to DNA containing primer terminal FapydG base-paired with a dC | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*GP*CP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(FAP))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFF
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![BU of 8vff by Molmil](/molmil-images/mine/8vff) | Binary DNA Polymerase Beta bound to DNA containing primer terminal FapydG base-paired with a dA | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(FAP))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFE
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![BU of 8vfe by Molmil](/molmil-images/mine/8vfe) | Binary DNA Polymerase Beta bound to DNA containing primer terminal FapydG base-paired with a T | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(FAP))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFD
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![BU of 8vfd by Molmil](/molmil-images/mine/8vfd) | Ternary DNA Polymerase Beta bound to DNA containing template FapydG incoming TTP analog | 分子名称: | 1-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]-beta-D-threo-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione, DNA (5'-D(*CP*CP*GP*AP*CP*(FAP)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFC
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![BU of 8vfc by Molmil](/molmil-images/mine/8vfc) | Binary DNA Polymerase Beta bound to DNA containing primer terminal T base-paired with FapydG | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*GP*(FAP)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*T)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFB
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![BU of 8vfb by Molmil](/molmil-images/mine/8vfb) | Ternary DNA Polymerase Beta bound to DNA containing primer terminal dA base-paired with FapydG | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*CP*(FAP)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VFA
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![BU of 8vfa by Molmil](/molmil-images/mine/8vfa) | Ternary DNA Polymerase Beta bound to DNA containing primer terminal dC base-paired with FapydG | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*CP*(FAP)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VF9
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![BU of 8vf9 by Molmil](/molmil-images/mine/8vf9) | Binary DNA Polymerase Beta bound to DNA containing primer terminal dA base-paired with FapydG | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*CP*(FAP)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VF8
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![BU of 8vf8 by Molmil](/molmil-images/mine/8vf8) | Binary DNA Polymerase Beta bound to DNA containing primer terminal dC base-paired with FapydG | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*CP*(FAP)P*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Oden, P.N, Ryan, B.J, Freudenthal, B.D. | 登録日 | 2023-12-21 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Biochemical and structural characterization of Fapy•dG replication by Human DNA polymerase beta. Nucleic Acids Res., 52, 2024
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8VF6
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![BU of 8vf6 by Molmil](/molmil-images/mine/8vf6) | Crystal structure of Serine/threonine-protein kinase 33 (STK33) Kinase Domain in complex with inhibitor CDD-2211 | 分子名称: | Serine/threonine-protein kinase 33, {3-[([1,1'-biphenyl]-2-yl)ethynyl]-1H-indazol-5-yl}[(3R)-3-(dimethylamino)pyrrolidin-1-yl]methanone | 著者 | Ta, H.M, Kim, C, Ku, K.A, Matzuk, M.M. | 登録日 | 2023-12-21 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science, 384, 2024
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8VF3
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![BU of 8vf3 by Molmil](/molmil-images/mine/8vf3) | |
8VF0
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![BU of 8vf0 by Molmil](/molmil-images/mine/8vf0) | |
8VEY
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![BU of 8vey by Molmil](/molmil-images/mine/8vey) | |
8VEX
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![BU of 8vex by Molmil](/molmil-images/mine/8vex) | |
8VEW
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![BU of 8vew by Molmil](/molmil-images/mine/8vew) | Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 24 | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 5-{2-[(2R,5S)-5-methyl-2-phenylpiperidin-1-yl](oxo)acetamido}pyridine-3-carboxamide, CHLORIDE ION, ... | 著者 | Whittington, D.A. | 登録日 | 2023-12-20 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67, 2024
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8VEV
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![BU of 8vev by Molmil](/molmil-images/mine/8vev) | |
8VEU
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![BU of 8veu by Molmil](/molmil-images/mine/8veu) | |
8VET
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![BU of 8vet by Molmil](/molmil-images/mine/8vet) | |
8VEQ
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![BU of 8veq by Molmil](/molmil-images/mine/8veq) | Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041 in complex with azlocillin | 分子名称: | (2R,4S)-5,5-dimethyl-2-[(1R)-2-oxo-1-{[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetyl]amino}ethyl]-1,3-thiazolidine-4-carboxylic acid, Probable peptidoglycan D,D-transpeptidase PenA | 著者 | Stratton, C, Bala, S, Davies, C. | 登録日 | 2023-12-20 | 公開日 | 2024-03-20 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041. Acs Infect Dis., 10, 2024
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