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6P6D
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HUMAN IGG1 FC FRAGMENT, C239 INSERTION MUTANT
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, IgG1 Fc fragment
著者Gallagher, D.T, Dimasi, N, McCullough, C.
登録日2019-06-03
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.
Pharmaceutics, 11, 2019
7NMO
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Crystal structure of beta-2-microglobulin D76A mutant
分子名称: Beta-2-microglobulin
著者Guthertz, N.
登録日2021-02-23
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.
Proc.Natl.Acad.Sci.USA, 119, 2022
7NMR
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Crystal structure of beta-2-microglobulin D76S mutant
分子名称: Beta-2-microglobulin, GLYCEROL
著者Guthertz, N.
登録日2021-02-23
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.
Proc.Natl.Acad.Sci.USA, 119, 2022
7NMT
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Crystal structure of beta-2-microglobulin D76G mutant
分子名称: Beta-2-microglobulin
著者Guthertz, N.
登録日2021-02-23
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.
Proc.Natl.Acad.Sci.USA, 119, 2022
7NMC
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Crystal structure of beta-2-microglobulin D76E mutant
分子名称: Beta-2-microglobulin, GLYCEROL, TRIETHYLENE GLYCOL
著者Guthertz, N.
登録日2021-02-23
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.
Proc.Natl.Acad.Sci.USA, 119, 2022
7NMV
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Crystal structure of beta-2-microglobulin D76Q mutant
分子名称: Beta-2-microglobulin
著者Guthertz, N.
登録日2021-02-23
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.
Proc.Natl.Acad.Sci.USA, 119, 2022
7NMY
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Crystal structure of beta-2-microglobulin D76Y mutant
分子名称: Beta-2-microglobulin
著者Guthertz, N.
登録日2021-02-23
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.
Proc.Natl.Acad.Sci.USA, 119, 2022
7NN5
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Crystal structure of beta-2-microglobulin D76K mutant
分子名称: Beta-2-microglobulin
著者Guthertz, N.
登録日2021-02-24
公開日2022-08-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.242 Å)
主引用文献The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis.
Proc.Natl.Acad.Sci.USA, 119, 2022
5JIK
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Crystal structure of HER2 binding IgG1-Fc (Fcab H10-03-6)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Humm, A, Lobner, E, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-04-22
公開日2017-04-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
7NUI
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Crystal structure of HLA-B*08:01 in complex with ELRSRYWAI viral peptide
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
著者Mavridis, G, Giastas, P, Mpakali, A.
登録日2021-03-12
公開日2021-04-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of HLA-B*08:01 in complex with ELRSRYWAI viral peptide
To Be Published
5HYS
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Structure of IgE complexed with omalizumab
分子名称: Epididymis luminal protein 214, Ig epsilon chain C region, SULFATE ION, ...
著者Pennington, L.F, Tarchevskaya, S.S, Sathiyamoorthy, K, Jardetzky, T.S.
登録日2016-02-01
公開日2016-06-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.
Nat Commun, 7, 2016
5JIH
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Crystal structure of HER2 binding IgG1-Fc (Fcab STAB19)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
著者Humm, A, Lobner, E, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-04-22
公開日2017-04-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.663 Å)
主引用文献Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
5IQ9
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Crystal structure of 10E8v4 Fab in complex with an HIV-1 gp41 peptide.
分子名称: 10E8v4 Heavy Chain, 10E8v4 Light Chain, gp41 MPER peptide
著者Ofek, G, Kwon, Y.D, Caruso, W, Kwong, P.D.
登録日2016-03-10
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
J.Virol., 90, 2016
5HYI
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Glycosylated, disulfide-linked Hole-Hole Fc fragment
分子名称: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Kuglstatter, A, Stihle, M, Benz, J.
登録日2016-02-01
公開日2017-02-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural differences between glycosylated, disulfide-linked heterodimeric Knob-into-Hole Fc fragment and its homodimeric Knob-Knob and Hole-Hole side products.
Protein Eng. Des. Sel., 30, 2017
5JII
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BU of 5jii by Molmil
Crystal structure of human IgG1-Fc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ig gamma-1 chain C region, ...
著者Humm, A, Lobner, E, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-04-22
公開日2017-04-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies.
Structure, 25, 2017
5IW3
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anti-CD20 monoclonal antibody Fc fragment
分子名称: ACETATE ION, Ig gamma-1 chain C region, SULFATE ION, ...
著者Tang, C, Chen, Z.
登録日2016-03-21
公開日2017-03-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure of anti-CD20 monoclonal antibody Fc fragment at 2.05 Angstroms resolution
To Be Published
5IW6
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BU of 5iw6 by Molmil
anti-CD20 monoclonal antibody Fc fragment
分子名称: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Tang, C, Chen, Z.
登録日2016-03-22
公開日2017-03-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Structure of anti-CD20 monoclonal antibody Fc fragment at 2.34 Angstroms resolution
To Be Published
5K65
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Crystal structure of VEGF binding IgG1-Fc (Fcab CT6)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Humm, A, Lobner, E, Kitzmuller, M, Mlynek, G, Obinger, C, Djinovic-Carugo, K.
登録日2016-05-24
公開日2017-09-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex.
MAbs, 9, 2017
1YEC
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STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.3)
分子名称: 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE, IGG2A FAB FRAGMENT (D2.3), ZINC ION
著者Golinelli-Pimpaneau, B, Knossow, M.
登録日1997-04-15
公開日1997-10-15
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural convergence in the active sites of a family of catalytic antibodies.
Science, 275, 1997
1YEH
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STRUCTURE OF IGG2A FAB FRAGMENT
分子名称: FAB FRAGMENT, ZINC ION
著者Gigant, B, Knossow, M.
登録日1997-05-29
公開日1997-12-03
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release.
Proc.Natl.Acad.Sci.USA, 94, 1997
1YEG
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STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH REACTION PRODUCT
分子名称: ACETATE ION, IGG2A FAB FRAGMENT, PARANITROBENZYL ALCOHOL, ...
著者Gigant, B, Knossow, M.
登録日1997-05-29
公開日1997-12-03
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release.
Proc.Natl.Acad.Sci.USA, 94, 1997
1YEE
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STRUCTURE OF A CATALYTIC ANTIBODY, IGG2A FAB FRAGMENT (D2.5)
分子名称: 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE, IGG2A FAB FRAGMENT (D2.5)
著者Golinelli-Pimpaneau, B, Knossow, M.
登録日1997-04-15
公開日1997-10-15
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural convergence in the active sites of a family of catalytic antibodies.
Science, 275, 1997
1ZVS
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Crystal structure of the first class MHC mamu and Tat-Tl8 complex
分子名称: Beta-2-microglobulin, MHC class I antigen, Tat-Tl8
著者Lou, Z, Chu, F, Gao, G.F, Rao, Z.
登録日2005-06-02
公開日2006-06-13
最終更新日2019-11-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献First glimpse of the peptide presentation by rhesus macaque MHC class I: crystal structures of Mamu-A*01 complexed with two immunogenic SIV epitopes and insights into CTL escape.
J Immunol., 178, 2007
1YEF
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STRUCTURE OF IGG2A FAB FRAGMENT (D2.3) COMPLEXED WITH SUBSTRATE ANALOGUE
分子名称: IGG2A FAB FRAGMENT, PARA-NITROBENZYL GLUTARYL GLYCINIC ACID, ZINC ION
著者Gigant, B, Knossow, M.
登録日1997-05-29
公開日1997-12-03
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray structures of a hydrolytic antibody and of complexes elucidate catalytic pathway from substrate binding and transition state stabilization through water attack and product release.
Proc.Natl.Acad.Sci.USA, 94, 1997
1YED
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STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4)
分子名称: 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE, IGG1 FAB FRAGMENT (D.2.4)
著者Golinelli-Pimpaneau, B, Knossow, M.
登録日1997-04-15
公開日1997-10-15
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural convergence in the active sites of a family of catalytic antibodies.
Science, 275, 1997

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