3V4F
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![BU of 3v4f by Molmil](/molmil-images/mine/3v4f) | H-Ras PEG 400/CaCl2, ordered off | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, CALCIUM ION, GTPase HRas, ... | 著者 | Holzapfel, G, Mattos, C. | 登録日 | 2011-12-14 | 公開日 | 2012-08-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.391 Å) | 主引用文献 | Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
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2YC2
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2YC4
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![BU of 2yc4 by Molmil](/molmil-images/mine/2yc4) | Intraflagellar Transport Complex 25-27 from Chlamydomonas | 分子名称: | CALCIUM ION, CHLORIDE ION, INTRAFLAGELLAR TRANSPORT PROTEIN 25, ... | 著者 | Bhogaraju, S, Taschner, M, Lorentzen, E. | 登録日 | 2011-03-11 | 公開日 | 2011-03-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of the Intraflagellar Transport Complex 25/27. Embo J., 30, 2011
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3TVD
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121P
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![BU of 121p by Molmil](/molmil-images/mine/121p) | STRUKTUR UND GUANOSINTRIPHOSPHAT-HYDROLYSEMECHANISMUS DES C-TERMINAL VERKUERZTEN MENSCHLICHEN KREBSPROTEINS P21-H-RAS | 分子名称: | H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | 著者 | Krengel, U, Scheffzek, K, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. | 登録日 | 1991-06-06 | 公開日 | 1994-01-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Struktur Und Guanosintriphosphat-Hydrolysemechanismus Des C-Terminal Verkuerzten Menschlichen Krebsproteins P21-H-Ras Thesis, 1991
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1A4R
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![BU of 1a4r by Molmil](/molmil-images/mine/1a4r) | G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM | 分子名称: | AMINOPHOSPHONIC ACID-GUANYLATE ESTER, G25K GTP-BINDING PROTEIN, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Rudolph, M.G, Vetter, I.R, Wittinghofer, A. | 登録日 | 1998-02-02 | 公開日 | 1999-03-02 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal. Protein Sci., 8, 1999
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1A2B
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![BU of 1a2b by Molmil](/molmil-images/mine/1a2b) | HUMAN RHOA COMPLEXED WITH GTP ANALOGUE | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN RHOA | 著者 | Ihara, K, Muraguchi, S, Kato, M, Shimizu, T, Shirakawa, M, Kuroda, S, Kaibuchi, K, Hakoshima, T. | 登録日 | 1997-12-26 | 公開日 | 1998-06-17 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue. J.Biol.Chem., 273, 1998
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1AGP
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![BU of 1agp by Molmil](/molmil-images/mine/1agp) | THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS | 分子名称: | C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Franken, S.M, Scheidig, A.J, Wittinghofer, A, Goody, R.S. | 登録日 | 1993-03-29 | 公開日 | 1994-04-30 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry, 32, 1993
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1AA9
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![BU of 1aa9 by Molmil](/molmil-images/mine/1aa9) | HUMAN C-HA-RAS(1-171)(DOT)GDP, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | C-HA-RAS, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Ito, Y, Yamasaki, Y, Muto, Y, Kawai, G, Nishimura, S, Miyazawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 1997-01-27 | 公開日 | 1997-07-29 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein. Biochemistry, 36, 1997
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1AJE
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![BU of 1aje by Molmil](/molmil-images/mine/1aje) | CDC42 FROM HUMAN, NMR, 20 STRUCTURES | 分子名称: | CDC42HS | 著者 | Feltham, J.L, Dotsch, V, Raza, S, Manor, D, Cerione, R.A, Sutcliffe, M.J, Wagner, G, Oswald, R.E. | 登録日 | 1997-05-02 | 公開日 | 1997-11-12 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Definition of the switch surface in the solution structure of Cdc42Hs. Biochemistry, 36, 1997
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1AN0
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![BU of 1an0 by Molmil](/molmil-images/mine/1an0) | CDC42HS-GDP COMPLEX | 分子名称: | CDC42HS-GDP, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Kongsaeree, P, Cerione, R, Clardy, J. | 登録日 | 1997-06-26 | 公開日 | 1999-01-13 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The Structure Determination of Cdc42Hs and Gdp Complex To be Published
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6GQX
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![BU of 6gqx by Molmil](/molmil-images/mine/6gqx) | KRAS-169 Q61H GPPNHP + CH-2 | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Cruz-Migoni, A, Quevedo, C.E, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H. | 登録日 | 2018-06-08 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6HDU
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6HXU
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![BU of 6hxu by Molmil](/molmil-images/mine/6hxu) | Crystal structure of Human RHOB Q63L in complex with GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho-related GTP-binding protein RhoB | 著者 | Soulie, S, Gence, R, Cabantous, S, Lajoie-Mazenc, I, Favre, G, Pedelacq, J.D. | 登録日 | 2018-10-18 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation. Cell Chem Biol, 26, 2019
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6HH2
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![BU of 6hh2 by Molmil](/molmil-images/mine/6hh2) | Rab29 small GTPase bound to GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7L1 | 著者 | Khan, A.R, McGrath, E, Waschbusch, D. | 登録日 | 2018-08-24 | 公開日 | 2019-09-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.449 Å) | 主引用文献 | LRRK2 binds to the Rab32 subfamily in a GTP-dependent mannerviaits armadillo domain. Small GTPases, 2019
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1CRQ
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![BU of 1crq by Molmil](/molmil-images/mine/1crq) | THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY | 分子名称: | C-H-RAS P21 PROTEIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Kraulis, P.J, Domaille, P.J, Campbell-Burk, S.L, Van Aken, T, Laue, E.D. | 登録日 | 1993-11-24 | 公開日 | 1994-07-31 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy. Biochemistry, 33, 1994
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6HUF
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![BU of 6huf by Molmil](/molmil-images/mine/6huf) | Coping with strong translational non-crystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-27A | 著者 | Jamshidiha, M, Perez-Dorado, I, Murray, J.W, Tate, E.W, Cota, E, Read, R.J. | 登録日 | 2018-10-08 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a. Acta Crystallogr D Struct Biol, 75, 2019
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4JS0
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![BU of 4js0 by Molmil](/molmil-images/mine/4js0) | Complex of Cdc42 with the CRIB-PR domain of IRSp53 | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Brain-specific angiogenesis inhibitor 1-associated protein 2, Cell division control protein 42 homolog, ... | 著者 | Kast, D.J, Dominguez, R. | 登録日 | 2013-03-22 | 公開日 | 2014-03-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nat.Struct.Mol.Biol., 21, 2014
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1CTQ
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![BU of 1ctq by Molmil](/molmil-images/mine/1ctq) | STRUCTURE OF P21RAS IN COMPLEX WITH GPPNHP AT 100 K | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN (TRANSFORMING PROTEIN P21/H-RAS-1) | 著者 | Scheidig, A, Burmester, C, Goody, R.S. | 登録日 | 1999-08-20 | 公開日 | 1999-11-15 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. Structure Fold.Des., 7, 1999
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6GOM
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![BU of 6gom by Molmil](/molmil-images/mine/6gom) | KRAS-169 Q61H GPPNHP + PPIN-1 | 分子名称: | (6~{S})-1-(1~{H}-imidazol-4-ylcarbonyl)-6-[(4-phenylphenyl)methyl]-4-propyl-1,4-diazepan-5-one, CITRIC ACID, GTPase KRas, ... | 著者 | Cruz-Migoni, A, Canning, P, Quevedo, C.E, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H. | 登録日 | 2018-06-01 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6H46
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![BU of 6h46 by Molmil](/molmil-images/mine/6h46) | Human KRAS in complex with darpin K13 | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ... | 著者 | Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H. | 登録日 | 2018-07-20 | 公開日 | 2019-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe. Nat Commun, 10, 2019
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1CLU
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![BU of 1clu by Molmil](/molmil-images/mine/1clu) | H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP | 分子名称: | 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1 | 著者 | Ahmadian, M.R, Zor, T, Vogt, D, Kabsch, W, Selinger, Z, Wittinghofer, A, Scheffzek, K. | 登録日 | 1999-05-03 | 公開日 | 1999-05-28 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proc.Natl.Acad.Sci.USA, 96, 1999
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6GJ6
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![BU of 6gj6 by Molmil](/molmil-images/mine/6gj6) | CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 18 | 分子名称: | (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... | 著者 | Kessler, D, Mcconnell, D.M, Mantoulidis, A, Phan, J. | 登録日 | 2018-05-16 | 公開日 | 2019-07-31 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.761 Å) | 主引用文献 | Drugging an undruggable pocket on KRAS. Proc.Natl.Acad.Sci.USA, 116, 2019
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6GJ8
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![BU of 6gj8 by Molmil](/molmil-images/mine/6gj8) | CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852 | 分子名称: | (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... | 著者 | Kessler, D, Mcconnell, D.M, Mantoulidis, A. | 登録日 | 2018-05-16 | 公開日 | 2019-07-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Drugging an undruggable pocket on KRAS. Proc.Natl.Acad.Sci.USA, 116, 2019
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1EK0
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![BU of 1ek0 by Molmil](/molmil-images/mine/1ek0) | GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICKEL (II) ION, ... | 著者 | Esters, H, Scheidig, A.J. | 登録日 | 2000-03-06 | 公開日 | 2000-04-17 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis. J.Mol.Biol., 298, 2000
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