PDB: 66910 件ウェブページステータス検索Chemie searchBIRD

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5EXM	FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[2-[(1~{S})-1-[[4-(aminomethyl)cyclohexyl]carbonylamino]-2-phenyl-ethyl]pyridin-4-yl]phenyl]carbamate 分子名称: 1,2-ETHANEDIOL, Coagulation factor XIa light chain, SULFATE ION, ... 著者 Wei, A. 登録日 2015-11-23 公開日 2016-04-13 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group Bioorg.Med.Chem., 24, 2016
2E8U	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and IPP (P21) 分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION 著者 Guo, R.T, Chen, C.K.-M, Ko, T.P, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. 登録日 2007-01-23 公開日 2007-06-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
2E91	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-91 分子名称: Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, ZOLEDRONIC ACID 著者 Guo, R.T, Ko, T.P, Cao, R, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. 登録日 2007-01-24 公開日 2007-06-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
5EST	Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate 分子名称: CALCIUM ION, ELASTASE, N~2~-[(benzyloxy)carbonyl]-N-[(1R,2S)-1-(dihydroxyboranyl)-2-methylbutyl]-L-alaninamide, ... 著者 Takahashi, L.H, Radhakrishnan, R, Rosenfieldjunior, R.E, Meyerjunior, E.F. 登録日 1989-05-15 公開日 1992-04-15 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystallographic analysis of the inhibition of porcine pancreatic elastase by a peptidyl boronic acid: structure of a reaction intermediate. Biochemistry, 28, 1989
2ENB	CRYSTAL STRUCTURES OF THE BINARY CA2+ AND PDTP COMPLEXES AND THE TERNARY COMPLEX OF THE ASP 21->GLU MUTANT OF STAPHYLOCOCCAL NUCLEASE. IMPLICATIONS FOR CATALYSIS AND LIGAND BINDING 分子名称: STAPHYLOCOCCAL NUCLEASE, THYMIDINE-3',5'-DIPHOSPHATE 著者 Libson, A, Gittis, A, Lattman, E.E. 登録日 1994-03-23 公開日 1994-05-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structures of the binary Ca2+ and pdTp complexes and the ternary complex of the Asp21-->Glu mutant of staphylococcal nuclease. Implications for catalysis and ligand binding. Biochemistry, 33, 1994
2EU8	Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (Q199R) 分子名称: Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, CALCIUM ION, ... 著者 Chen, S, Shamoo, Y. 登録日 2005-10-28 公開日 2006-06-27 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 In vivo molecular evolution reveals biophysical origins of organismal fitness. Mol.Cell, 22, 2006
2AOT	Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine 分子名称: Histamine N-methyltransferase, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, S-ADENOSYL-L-HOMOCYSTEINE 著者 Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. 登録日 2005-08-14 公開日 2005-09-13 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
2ATK	Structure of a mutant KcsA K+ channel 分子名称: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, NONAN-1-OL, ... 著者 Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Chakrapani, S, Roux, B, Perozo, E. 登録日 2005-08-25 公開日 2006-03-07 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular determinants of gating at the potassium-channel selectivity filter. Nat.Struct.Mol.Biol., 13, 2006
2HRW	Crystal Structure of Phosphonopyruvate Hydrolase 分子名称: CHLORIDE ION, Phosphonopyruvate hydrolase, SODIUM ION 著者 Chen, C.C.H, Herzberg, O. 登録日 2006-07-20 公開日 2006-10-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and Kinetics of Phosphonopyruvate Hydrolase from Voriovorax sp. Pal2: New Insight into the Divergence of Catalysis within the PEP Mutase/Isocitrate Lyase Superfamily Biochemistry, 45, 2006
2AOW	Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine 分子名称: Histamine N-methyltransferase, TACRINE 著者 Horton, J.R, Sawada, K, Nishibori, M, Cheng, X. 登録日 2005-08-14 公開日 2005-09-13 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353, 2005
2JWU	Solution NMR structures of two designed proteins with 88% sequence identity but different fold and function 分子名称: Gb88 著者 He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. 登録日 2007-10-25 公開日 2008-09-09 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 NMR structures of two designed proteins with high sequence identity but different fold and function Proc.Natl.Acad.Sci.Usa, 105, 2008
2FM2	HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211 分子名称: BETA-MERCAPTOETHANOL, NS3 protease/helicase, NS4a protein, ... 著者 Yi, M, Tong, X, Skelton, A, Chase, R, Chen, T, Prongay, A, Bogen, S.L, Saksena, A.K, Njoroge, F.G, Veselenak, R.L, Pyles, R.B, Bourne, N, Malcolm, B.A, Lemon, S.M. 登録日 2006-01-06 公開日 2006-02-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations J.Biol.Chem., 281, 2006
2FME	Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide 分子名称: (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, ... 著者 Sheriff, S. 登録日 2006-01-09 公開日 2006-04-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series Bioorg.Med.Chem.Lett., 16, 2006
2H62	Crystal structure of a ternary ligand-receptor complex of BMP-2 分子名称: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Mueller, T.D. 登録日 2006-05-30 公開日 2007-04-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. Bmc Struct.Biol., 7, 2007
2GVF	HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021 分子名称: (6R,8S,11S)-11-CYCLOHEXYL-N-(1-{[(2-{[(1S)-2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO}-2-OXOETHYL)AMINO](OXO)ACETYL}BUTYL)-10,13-DIOXO-2,5-DIOXA-9,12-DIAZATRICYCLO[14.3.1.1~6,9~]HENICOSA-1(20),16,18-TRIENE-8-CARBOXAMIDE, Polyprotein, ZINC ION, ... 著者 Arasappan, A, Njoroge, F.G, Chen, K.X, Venkatraman, S, Parekh, T.N, Gu, H, Pichardo, J, Butkiewicz, N, Prongay, A, Madison, V, Girijavallabhan, V. 登録日 2006-05-02 公開日 2007-01-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease. Bioorg.Med.Chem.Lett., 16, 2006
2DUA	Crystal Structure of Phosphonopyruvate Hydrolase Complex with Oxalate and Mg++ 分子名称: CHLORIDE ION, MAGNESIUM ION, OXALATE ION, ... 著者 Herzberg, O, Chen, C. 登録日 2006-07-21 公開日 2006-10-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and Kinetics of Phosphonopyruvate Hydrolase from Voriovorax sp. Pal2: New Insight into the Divergence of Catalysis within the PEP Mutase/Isocitrate Lyase Superfamily Biochemistry, 45, 2006
2EH7	Crystal structure of humanized KR127 FAB 分子名称: HUMANIZED KR127 FAB, HEAVY CHAIN, LIGHT CHAIN 著者 Chi, S.-W, Kim, S.-J, Maeng, C.-Y, Hong, H.J, Ryu, S.-E. 登録日 2007-03-05 公開日 2008-01-15 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Broadly neutralizing anti-hepatitis B virus antibody reveals a complementarity determining region H3 lid-opening mechanism Proc.Natl.Acad.Sci.Usa, 104, 2007
2E99	E. coli undecaprenyl pyrophosphate synthase in complex with BPH-608 分子名称: (1-HYDROXY-1-PHOSPHONO-2-[1,1';3',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID, Undecaprenyl pyrophosphate synthetase 著者 Guo, R.T, Ko, T.P, Cao, R, Liang, P.H, Oldfield, E, Wang, A.H.J. 登録日 2007-01-24 公開日 2007-06-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
2JJ6	Crystal structure of the putative carbohydrate recognition domain of the human galectin-related protein 分子名称: GALECTIN-RELATED PROTEIN 著者 Thore, S, Walti, M.A, Kunzler, M, Aebi, M. 登録日 2008-03-18 公開日 2008-05-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Putative Carbohydrate Recognition Domain of Human Galectin-Related Protein Proteins: Struct., Funct., Bioinf., 72, 2008
2HAQ	Crystal Structure of Cyclophilin A from Leishmania Donovani 分子名称: Cyclophilin 著者 Venugopal, V, Sen, B, Datta, A.K, Banerjee, R. 登録日 2006-06-13 公開日 2006-06-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structure of cyclophilin from Leishmania donovani at 1.97 A resolution. Acta Crystallogr.,Sect.F, 63, 2007
2HC0	Structure of HIV protease 6X mutant in complex with AB-2. 分子名称: BROMIDE ION, Protease, [1-((1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL (1R,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YLCARBAMATE 著者 Heaslet, H, Brik, A, Lin, Y.-C, Elder, J.H, Stout, C.D. 登録日 2006-06-14 公開日 2007-06-26 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure of HIV Protease 6X Mutant in complex with AB-2 To be Published
2KA4	NMR structure of the CBP-TAZ1/STAT2-TAD complex 分子名称: Crebbp protein, Signal transducer and activator of transcription 2, ZINC ION 著者 Wojciak, J.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. 登録日 2008-10-30 公開日 2009-04-21 最終更新日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains Embo J., 28, 2009
2K71	Structure and dynamics of a DNA GNRA hairpin solved vy high-sensitivity NMR with two independent converging methods, simulated annealing (DYANA) and mesoscopic molecular modelling (BCE/AMBER) 分子名称: 5'-D(*DGP*DCP*DGP*DAP*DAP*DAP*DGP*DC)-3' 著者 Santini, G.P.H, Cognet, J.A.H, Xu, D, Singarapu, K.K, Herve du Penhoat, C.L.M. 登録日 2008-07-29 公開日 2009-07-21 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Nucleic acid folding determined by mesoscale modeling and NMR spectroscopy: solution structure of d(GCGAAAGC). J.Phys.Chem.B, 113, 2009
5JKN	Crystal structure of deubiquitinase MINDY-1 分子名称: DI(HYDROXYETHYL)ETHER, MERCURY (II) ION, PHOSPHATE ION, ... 著者 Abdul Rehman, S.A, Kulathu, Y. 登録日 2016-04-26 公開日 2016-06-22 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Mol.Cell, 63, 2016
5TNU	S. tokodaii XPB II crystal structure at 3.0 Angstrom resolution 分子名称: CHLORIDE ION, DNA-dependent ATPase XPBII, GLYCEROL, ... 著者 DuPrez, K.T, Hilario, E, Wang, I, Fan, L. 登録日 2016-10-14 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Application of Electrochemical Devices to Characterize the Dynamic Actions of Helicases on DNA. Anal.Chem., 90, 2018

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