PDB: 223790 件ウェブページステータス検索Chemie searchBIRD

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6DQC	LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N50 i.e. 2-(4-((2-(dimethylamino)ethyl)(ethyl)carbamoyl)-5-(4-methoxyphenyl)-1H-pyrazol-1-yl)isonicotinic acid 分子名称: 2-[4-{[2-(dimethylamino)ethyl](ethyl)carbamoyl}-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Horton, J.R, Cheng, X. 登録日 2018-06-10 公開日 2019-06-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.755 Å) 主引用文献 To be determined To Be Published
6DDS	Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid 分子名称: 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid, ACETATE ION, Dihydrofolate reductase, ... 著者 Hajian, B, Wright, D, Scocchera, E. 登録日 2018-05-10 公開日 2018-05-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents. Cell Chem Biol, 26, 2019
6DEK	Crystal structure of Candida albicans acetohydroxyacid synthase catalytic subunit 分子名称: Acetolactate synthase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... 著者 Garcia, M.D, Guddat, L.W. 登録日 2018-05-12 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.971 Å) 主引用文献 Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DER	Crystal structure of Candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam 分子名称: (3Z)-4-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}-3-MERCAPTOPENT-3-EN-1-YL TRIHYDROGEN DIPHOSPHATE, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Acetolactate synthase, ... 著者 Garcia, M.D, Guddat, L.W. 登録日 2018-05-12 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.126 Å) 主引用文献 Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7CNT	Structure of 2,5-dihydroxypridine Dioxygenase from Pseudomonas putida KT2440 in complex with product N-formylmaleamic acid formed via in crystallo reaction with 2,5-dihydroxypridine 分子名称: 2,5-dihydroxypyridine 5,6-dioxygenase, FE (II) ION 著者 Liu, G.Q, Tang, H.Z. 登録日 2020-08-03 公開日 2020-12-16 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 2,5-dihydroxypridine Dioxygenase in complex with 2,5-dihydroxypridine and product N-formylmaleamic acid Nat Commun, 2020
6DXI	Crystal structure of H-NOX protein from Nostoc sp V52W/L67W double-mutant. 分子名称: H-NOX, PROTOPORPHYRIN IX CONTAINING FE 著者 Weichsel, A, Kievenaar, J.A, Montfort, W.R. 登録日 2018-06-28 公開日 2018-07-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of H-NOX domain from cyanobacteria Nostoc sp to be published
6DXR	Structure of the Monoclinic-2 (Monocl-2) Crystal Form of Human Apolipoprotein C1 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Apolipoprotein C-I 著者 McPherson, A. 登録日 2018-06-29 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The structure of human apolipoprotein C-1 in four different crystal forms. J. Lipid Res., 60, 2019
6D4C	Crystal structure of Candida boidinii formate dehydrogenase V123G mutant complexed with NAD+ and azide 分子名称: AZIDE ION, CHLORIDE ION, Formate dehydrogenase, ... 著者 Guo, Q, Ye, H, Gakhar, L, Cheatum, C.M, Kohen, A. 登録日 2018-04-17 公開日 2019-04-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase Acs Catalysis, 2019
6D6X	HSP40 co-chaperone Sis1 J-domain 分子名称: Type II HSP40 co-chaperone 著者 Pinheiro, G.M.S, Amorim, G.C, Iqbal, A, Ramos, C.H.I, Almeida, F.C.L. 登録日 2018-04-23 公開日 2019-05-01 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution NMR investigation on the structure and function of the isolated J-domain from Sis1: Evidence of transient inter-domain interactions in the full-length protein. Arch.Biochem.Biophys., 669, 2019
6DKE	The X-ray crystal structure of Streptococcus pneumoniae Fatty Acid Kinase (Fak) B1 protein loaded with palmitic acid (C16:0) to 1.76 Angstrom resolution 分子名称: Fatty Acid Kinase (Fak) B1 protein, PALMITIC ACID 著者 Cuypers, M.G, Subramanian, C, White, S.W, Rock, C.O. 登録日 2018-05-29 公開日 2019-05-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 The X-ray crystal structure of Streptococcus pneumoniae Fatty Acid Kinase (Fak) B1 protein loaded with palmitic acid (C16:0) to 1.76 Angstrom resolution To Be Published
6DKH	The crystal structure of L-idonate 5-dehydrogenase from Escherichia coli str. K-12 substr. MG1655 分子名称: L-idonate 5-dehydrogenase (NAD(P)(+)), ZINC ION 著者 Tan, K, Evdokimova, E, McChesney, C, Savchenko, A, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2018-05-29 公開日 2018-06-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.608 Å) 主引用文献 The crystal structure of L-idonate 5-dehydrogenase from Escherichia coli str. K-12 substr. MG1655 To Be Published
6D6M	The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 15 分子名称: 2,4-dibromo-6-{[(2-nitrobenzene-1-carbonyl)amino]methyl}phenyl 4-bromobenzoate, Transcriptional activator protein LasR 著者 Dong, S.H, Nair, S.K. 登録日 2018-04-21 公開日 2018-08-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR. Cell Chem Biol, 25, 2018
6D7F	Bacteroides uniformis beta-glucuronidase 1 bound to thiophenyl-beta-D-glucuronide 分子名称: Beta-galactosidase/beta-glucuronidase, CHLORIDE ION, GLYCEROL, ... 著者 Walton, W.G, Pellock, S.J, Redinbo, M.R. 登録日 2018-04-24 公開日 2018-10-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
6D87	Structure of the Bovine p85alpha BH domain, R262T mutant 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION 著者 Moore, S.A, Marshall, J.D, Anderson, D.H. 登録日 2018-04-25 公開日 2018-05-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Patient-derived mutations within the N-terminal domains of p85 alpha impact PTEN or Rab5 binding and regulation. Sci Rep, 8, 2018
6D8K	Bacteroides multiple species beta-glucuronidase 分子名称: Glycosyl hydrolase family 2, sugar binding domain protein 著者 Walton, W.G, Pellock, S.J, Redinbo, M.R. 登録日 2018-04-26 公開日 2018-10-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
6D9F	Protein 60 with aldehyde deformylating oxidase activity from Kitasatospora setae 分子名称: 1,2-ETHANEDIOL, FE (III) ION, Putative VlmB homolog, ... 著者 Arenas, R, Wilson, D.K, Mak, W.S, Siegel, J.B. 登録日 2018-04-28 公開日 2019-05-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Discovery, Design, and Structural Characterization of Alkane-Producing Enzymes across the Ferritin-like Superfamily. Biochemistry, 59, 2020
6D4Q	M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 14 (VCC900455) 分子名称: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, cycloheptyl{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}methanone 著者 Ascher, D.B, Pacitto, A, Blundell, T.L. 登録日 2018-04-18 公開日 2019-05-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. Eur.J.Med.Chem., 174, 2019
6D5M	Ras:SOS:Ras in complex with a small molecule activator 分子名称: 1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-2-(piperazin-1-yl)-1H-benzimidazole, GTPase HRas, MAGNESIUM ION, ... 著者 Phan, J, Hodges, T, Fesik, S.W. 登録日 2018-04-19 公開日 2018-09-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.081 Å) 主引用文献 Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J. Med. Chem., 61, 2018
6DQH	Cronobacter sakazakii (Enterobacter sakazakii) Metallo-beta-lactamse HARLDQ motif 分子名称: Beta-lactamase, PHOSPHATE ION, ZINC ION 著者 Monteiro Pedroso, M, Waite, D, Natasa, M, McGeary, R, Guddat, L, Hugenholtz, P, Schenk, G. 登録日 2018-06-11 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.104 Å) 主引用文献 Broad spectrum antibiotic-degrading metallo-beta-lactamases are phylogenetically diverse Protein Cell, 2020
6D63	The structure of AtzH: a little known member of the atrazine breakdown pathway 分子名称: 3-oxopentanedioic acid, atzH 著者 Peat, T.S, Newman, J, Scott, C, Esquirol, L. 登録日 2018-04-19 公開日 2018-11-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP. PLoS ONE, 13, 2018
6D6S	Solution structure of Trigger Factor dimer 分子名称: Trigger factor 著者 Saio, T, Kawagoe, S, Ishimori, K, Kalodimos, C.G. 登録日 2018-04-22 公開日 2018-06-13 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Oligomerization of a molecular chaperone modulates its activity. Elife, 7, 2018
6DBZ	Crystal structure of Nudix 1 from Arabidopsis thaliana complexed with isopentenyl diphosphate 分子名称: ISOPENTYL PYROPHOSPHATE, MAGNESIUM ION, Nudix hydrolase 1 著者 Noel, J.P, Thomas, S.T, Dudareva, N, Henry, L.K. 登録日 2018-05-03 公開日 2018-09-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nat Plants, 4, 2018
6DTK	Heterodimers of FALS mutant SOD enzyme 分子名称: COPPER (II) ION, MALONATE ION, Superoxide dismutase C111S/D83S-C111S HETERODIMER, ... 著者 Streltsov, V.A, Nuttall, S.D, Ganio, K.E, Roberts, B. 登録日 2018-06-17 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural characterization of heterodimers of FALS mutant SOD enzyme To Be Published
6DD2	Crystal structure of Selaginella moellendorffii HCT 分子名称: Probable hydroxycinnamoyl transferase 著者 Levsh, O, Chiang, Y.C, Lam, C.K, Wang, Y, Weng, J.K. 登録日 2018-05-09 公開日 2018-10-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9056 Å) 主引用文献 Structural and dynamic basis of substrate permissiveness in hydroxycinnamoyltransferase (HCT). PLoS Comput. Biol., 14, 2018
6DD7	Crystal structure of plant UVB photoreceptor UVR8 from in situ serial Laue diffraction 分子名称: Ultraviolet-B receptor UVR8 著者 Ren, Z. 登録日 2018-05-09 公開日 2018-07-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal-on-crystal chips for in situ serial diffraction at room temperature. Lab Chip, 18, 2018

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