6DDS
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid
Summary for 6DDS
Entry DOI | 10.2210/pdb6dds/pdb |
Related | 6DDP |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid, ... (7 entities in total) |
Functional Keywords | dhfr, antifolate, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 4 |
Total formula weight | 75777.94 |
Authors | Hajian, B.,Wright, D.,Scocchera, E. (deposition date: 2018-05-10, release date: 2018-05-23, Last modification date: 2023-10-11) |
Primary citation | Hajian, B.,Scocchera, E.,Shoen, C.,Krucinska, J.,Viswanathan, K.,G-Dayanandan, N.,Erlandsen, H.,Estrada, A.,Mikusova, K.,Kordulakova, J.,Cynamon, M.,Wright, D. Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents. Cell Chem Biol, 26:781-791.e6, 2019 Cited by PubMed: 30930162DOI: 10.1016/j.chembiol.2019.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
Download full validation report