6XVG
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8G8O
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![BU of 8g8o by Molmil](/molmil-images/mine/8g8o) | The crystal structure of JAK2 in complex with Compound 31 | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Tyrosine-protein kinase JAK2, ... | 著者 | Miller, S.T, Ellis, D.A. | 登録日 | 2023-02-18 | 公開日 | 2023-06-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J.Med.Chem., 66, 2023
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6XSG
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![BU of 6xsg by Molmil](/molmil-images/mine/6xsg) | Crystal structure of Staphylococcal nuclease variant Delta+PHS V66T at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Robinson, A.C, Schlessman, J.L, Garcia-Moreno E, B, Sorenson, J.L. | 登録日 | 2020-07-15 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of Staphylococcal nuclease variant Delta+PHS V66T at cryogenic temperature To be Published
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2AQ9
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![BU of 2aq9 by Molmil](/molmil-images/mine/2aq9) | Structure of E. coli LpxA with a bound peptide that is competitive with acyl-ACP | 分子名称: | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... | 著者 | Williams, A.H, Immormino, R.M, Gewirth, D.T, Raetz, C.R. | 登録日 | 2005-08-17 | 公開日 | 2006-06-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide. Proc.Natl.Acad.Sci.Usa, 103, 2006
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8GR3
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1JAL
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6XW4
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![BU of 6xw4 by Molmil](/molmil-images/mine/6xw4) | Crystal structure of murine norovirus P domain in complex with Nanobody NB-5867 | 分子名称: | 1,2-ETHANEDIOL, Capsid protein, Nanobody NB-5867 | 著者 | Kilic, T, Sabin, C, Hansman, G. | 登録日 | 2020-01-23 | 公開日 | 2020-04-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Nanobody-Mediated Neutralization Reveals an Achilles Heel for Norovirus. J.Virol., 94, 2020
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8GR6
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![BU of 8gr6 by Molmil](/molmil-images/mine/8gr6) | Crystal Structure of pilus-specific Sortase C from Streptococcus sanguinis | 分子名称: | 1,2-ETHANEDIOL, SODIUM ION, Sortase-like protein, ... | 著者 | Yadav, S, Parijat, P, Krishnan, V. | 登録日 | 2022-09-01 | 公開日 | 2023-06-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Crystal structure of the pilus-specific sortase from early colonizing oral Streptococcus sanguinis captures an active open-lid conformation. Int.J.Biol.Macromol., 243, 2023
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8GCL
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![BU of 8gcl by Molmil](/molmil-images/mine/8gcl) | Cryo-EM structure of hAQP2 in DDM | 分子名称: | Aquaporin-2 | 著者 | Kamegawa, A, Suzuki, S, Nishikawa, K, Numoto, N, Suzuki, H, Fujiyoshi, Y. | 登録日 | 2023-03-02 | 公開日 | 2023-06-21 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural analysis of the water channel AQP2 by single-particle cryo-EM. J.Struct.Biol., 215, 2023
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6B4A
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8G8X
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![BU of 8g8x by Molmil](/molmil-images/mine/8g8x) | X-ray co-crystal structure of compound 27 in with complex JAK2 | 分子名称: | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol, Tyrosine-protein kinase JAK2 | 著者 | Miller, S.T, Ellis, D.A. | 登録日 | 2023-02-20 | 公開日 | 2023-06-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J.Med.Chem., 66, 2023
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8GCB
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![BU of 8gcb by Molmil](/molmil-images/mine/8gcb) | Structure of RNF125 in complex with a UbcH5b~Ub conjugate | 分子名称: | E3 ubiquitin-protein ligase RNF125, Ubiquitin-conjugating enzyme E2 D2, ZINC ION | 著者 | Middleton, A.J, Day, C.L, Fokkens, T.J. | 登録日 | 2023-03-01 | 公開日 | 2023-07-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation. Structure, 31, 2023
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8GUV
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![BU of 8guv by Molmil](/molmil-images/mine/8guv) | LecA from Pseudomonas aeruginosa in complex with tolcapone (CAS: 134308-13-7) | 分子名称: | CALCIUM ION, PA-I galactophilic lectin, Tolcapone | 著者 | Kuhaudomlarp, S, Siebs, E, Varrot, A, Imberty, A, Titz, A. | 登録日 | 2022-09-13 | 公開日 | 2023-07-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | LecA from Pseudomonas aeruginosa in complex with tolcapone (CAS: 134308-13-7) To Be Published
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8GUU
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8GR1
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1JLT
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![BU of 1jlt by Molmil](/molmil-images/mine/1jlt) | Vipoxin Complex | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHOLIPASE A2, ... | 著者 | Banumathi, S, Rajashankar, K.R, Notzel, C, Aleksiev, B, Singh, T.P, Genov, N, Betzel, C. | 登録日 | 2001-07-16 | 公開日 | 2001-10-31 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure of the neurotoxic complex vipoxin at 1.4 A resolution. Acta Crystallogr.,Sect.D, 57, 2001
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1JKY
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![BU of 1jky by Molmil](/molmil-images/mine/1jky) | Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2 | 分子名称: | Lethal Factor, mitogen-activated protein kinase kinase 2 | 著者 | Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C. | 登録日 | 2001-07-13 | 公開日 | 2001-11-07 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Crystal structure of the anthrax lethal factor. Nature, 414, 2001
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6XYB
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![BU of 6xyb by Molmil](/molmil-images/mine/6xyb) | Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi | 分子名称: | CHLORIDE ION, IODIDE ION, MAGNESIUM ION, ... | 著者 | Roske, Y, Heinemann, U. | 登録日 | 2020-01-30 | 公開日 | 2020-06-10 | 最終更新日 | 2020-07-15 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi. J.Struct.Biol., 211, 2020
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6XOF
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![BU of 6xof by Molmil](/molmil-images/mine/6xof) | Crystal structure of SCLam, a non-specific endo-beta-1,3(4)-glucanase from family GH16 | 分子名称: | CALCIUM ION, GH16 family protein, GLYCEROL | 著者 | Liberato, M.V, Bernardes, A, Polikarpov, I, Squina, F. | 登録日 | 2020-07-07 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Insights into the dual cleavage activity of the GH16 laminarinase enzyme class on beta-1,3 and beta-1,4 glycosidic bonds. J.Biol.Chem., 296, 2021
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6XQM
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![BU of 6xqm by Molmil](/molmil-images/mine/6xqm) | Crystal structure of SCLam E144S mutant, a non-specific endo-beta-1,3(4)-glucanase from family GH16, co-crystallized with laminarihexaose, presenting a laminaribiose and a glucose at active site | 分子名称: | CALCIUM ION, GH16 family protein, PHOSPHATE ION, ... | 著者 | Liberato, M.V, Squina, F. | 登録日 | 2020-07-09 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Insights into the dual cleavage activity of the GH16 laminarinase enzyme class on beta-1,3 and beta-1,4 glycosidic bonds. J.Biol.Chem., 296, 2021
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6XQH
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![BU of 6xqh by Molmil](/molmil-images/mine/6xqh) | Crystal structure of SCLam E144S mutant, a non-specific endo-beta-1,3(4)-glucanase from family GH16, co-crystallized with cellotriose, presenting a 1,3-beta-D-cellobiosyl-glucose and a cellobiose at active site | 分子名称: | CALCIUM ION, GH16 family protein, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose, ... | 著者 | Liberato, M.V, Squina, F. | 登録日 | 2020-07-09 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Insights into the dual cleavage activity of the GH16 laminarinase enzyme class on beta-1,3 and beta-1,4 glycosidic bonds. J.Biol.Chem., 296, 2021
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6XQG
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![BU of 6xqg by Molmil](/molmil-images/mine/6xqg) | Crystal structure of SCLam E144S mutant, a non-specific endo-beta-1,3(4)-glucanase from family GH16, co-crystallized with 1,3-beta-D-cellobiosyl-cellobiose, presenting a 1,3-beta-D-cellobiosyl-glucose at active site | 分子名称: | CALCIUM ION, GH16 family protein, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-3)-alpha-D-glucopyranose | 著者 | Liberato, M.V, Squina, F. | 登録日 | 2020-07-09 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Insights into the dual cleavage activity of the GH16 laminarinase enzyme class on beta-1,3 and beta-1,4 glycosidic bonds. J.Biol.Chem., 296, 2021
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1JUC
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![BU of 1juc by Molmil](/molmil-images/mine/1juc) | Crystal Structure Analysis of a Holliday Junction Formed by CCGGTACCGG | 分子名称: | 5'-D(*CP*CP*GP*GP*TP*AP*CP*CP*GP*G)-3' | 著者 | Thorpe, J.H, Teixeira, S.C.M, Gale, B.C, Cardin, C.J. | 登録日 | 2001-08-24 | 公開日 | 2002-02-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural characterization of a new crystal form of the four-way Holliday junction formed by the DNA sequence d(CCGGTACCGG)2: sequence versus lattice? Acta Crystallogr.,Sect.D, 58, 2002
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2AYH
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![BU of 2ayh by Molmil](/molmil-images/mine/2ayh) | CRYSTAL AND MOLECULAR STRUCTURE AT 1.6 ANGSTROMS RESOLUTION OF THE HYBRID BACILLUS ENDO-1,3-1,4-BETA-D-GLUCAN 4-GLUCANOHYDROLASE H(A16-M) | 分子名称: | 1,3-1,4-BETA-D-GLUCAN 4-GLUCANOHYDROLASE, CALCIUM ION | 著者 | Hahn, M, Keitel, T, Heinemann, U. | 登録日 | 1995-02-02 | 公開日 | 1995-03-31 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal and molecular structure at 0.16-nm resolution of the hybrid Bacillus endo-1,3-1,4-beta-D-glucan 4-glucanohydrolase H(A16-M). Eur.J.Biochem., 232, 1995
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1KW6
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![BU of 1kw6 by Molmil](/molmil-images/mine/1kw6) | Crystal structure of 2,3-dihydroxybiphenyl dioxygenase (BphC) in complex with 2,3-dihydroxybiphenyl at 1.45 A resolution | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2,3-Dihydroxybiphenyl dioxygenase, BIPHENYL-2,3-DIOL, ... | 著者 | Sato, N, Uragami, Y, Nishizaki, T, Takahashi, Y, Sazaki, G, Sugimoto, K, Nonaka, T, Masai, E, Fukuda, M, Senda, T. | 登録日 | 2002-01-28 | 公開日 | 2003-01-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal Structures of the Reaction Intermediate and its Homologue of an Extradiol-cleaving Catecholic Dioxygenase J.Mol.Biol., 321, 2002
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