PDB: 5653 件ウェブページステータス検索Chemie searchBIRD

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5DRA	t3284 loop variant of beta1 分子名称: 3beta1 著者 Kabasakal, B.V, MacDonald, J.T, Murray, W.W. 登録日 2015-09-15 公開日 2016-08-31 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension. Proc.Natl.Acad.Sci.USA, 113, 2016
5DNS	t1428 loop variant in P3221 分子名称: t1428 beta1 loop design 著者 MacDonald, J.T, Kabasakal, B.V, Murray, J.W. 登録日 2015-09-10 公開日 2016-09-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.561 Å) 主引用文献 Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension. Proc.Natl.Acad.Sci.USA, 113, 2016
5KUY	Influenza hemagglutinin H3 A/Hong Kong/1/1968 in complex with designed inhibitor protein HSB.2A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Designed influenza inhibitor HSB.2A, ... 著者 Bernard, S.M, Wilson, I.A. 登録日 2016-07-13 公開日 2017-06-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.598 Å) 主引用文献 Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site. Nat. Biotechnol., 35, 2017
8CYK	Crystal structure of hallucinated protein HALC1_878 分子名称: HALC1_878 著者 Ragotte, R.J, Bera, A.K, Milles, L.F, Wicky, B.I.M, Baker, D. 登録日 2022-05-23 公開日 2022-09-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Robust deep learning-based protein sequence design using ProteinMPNN. Science, 378, 2022
1N0C	Stability of cyclic beta-hairpins: Asymmetric contibutions from side chains of hydrogen bonded cross-strand residue pair 分子名称: bhp_HWLV, disulfide cyclized beta-hairpin peptide 著者 Russel, S.J, Blandl, T, Skelton, N.J, Cochran, A.G. 登録日 2002-10-11 公開日 2003-10-21 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Stability of cyclic beta-hairpins: asymmetric contributions from side chains of a hydrogen-bonded cross-strand residue pair J.AM.CHEM.SOC., 125, 2003
2XI3	HCV-H77 NS5B Polymerase Complexed With GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA-directed RNA polymerase 著者 Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S. 登録日 2010-06-25 公開日 2010-08-04 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285, 2010
2XI2	HCV-H77 NS5B Apo Polymerase 分子名称: RNA-directed RNA polymerase, SULFATE ION 著者 Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S. 登録日 2010-06-25 公開日 2010-08-04 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285, 2010
8Q63	Cryo-EM structure of IC8', a second state of yeast mitochondrial RNA polymerase transcription initiation complex with 8-mer RNA, pppGpGpUpApApApUpG 分子名称: DNA-directed RNA polymerase, mitochondrial, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Goovaerts, Q, Shen, J, Patel, S.S, Das, K. 登録日 2023-08-10 公開日 2023-08-30 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.68 Å) 主引用文献 Structures illustrate step-by-step mitochondrial transcription initiation. Nature, 622, 2023
1PKX	Crystal Structure of human ATIC in complex with XMP 分子名称: Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, XANTHOSINE-5'-MONOPHOSPHATE 著者 Wolan, D.W, Cheong, C.G, Greasley, S.E, Wilson, I.A. 登録日 2003-06-06 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Insights into the Human and Avian IMP Cyclohydrolase Mechanism via Crystal Structures with the Bound XMP Inhibitor. Biochemistry, 43, 2004
1LT1	SLIDING HELIX INDUCED CHANGE OF COORDINATION GEOMETRY IN A MODEL DI-MN(II) PROTEIN 分子名称: L13G-DF1, MANGANESE (II) ION 著者 Di Costanzo, L, Geremia, S. 登録日 2002-05-20 公開日 2003-05-20 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Sliding helix and change of coordination geometry in a model di-MnII protein Angew.Chem.Int.Ed.Engl., 42, 2003
1BWS	CRYSTAL STRUCTURE OF GDP-4-KETO-6-DEOXY-D-MANNOSE EPIMERASE/REDUCTASE FROM ESCHERICHIA COLI A KEY ENZYME IN THE BIOSYNTHESIS OF GDP-L-FUCOSE 分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (GDP-4-KETO-6-DEOXY-D-MANNOSE EPIMERASE/REDUCTASE) 著者 Rizzi, M, Tonetti, M, Flora, A.D, Bolognesi, M. 登録日 1998-09-25 公開日 1999-01-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from Escherichia coli, a key enzyme in the biosynthesis of GDP-L-fucose, displays the structural characteristics of the RED protein homology superfamily. Structure, 6, 1998
6B6H	The cryo-EM structure of a bacterial class I transcription activation complex 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A. 登録日 2017-10-02 公開日 2017-11-15 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of bacterial transcription activation. Science, 358, 2017
2BXV	Dual binding mode of a novel series of DHODH inhibitors 分子名称: 2-({[3-FLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ... 著者 Baumgartner, R, Walloschek, M, Karlik, M, Gotschlich, A, Tasler, S, Mies, J, Leban, J. 登録日 2005-07-27 公開日 2006-08-16 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Dual binding mode of a novel series of DHODH inhibitors. J. Med. Chem., 49, 2006
6CAI	Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 24 round 7 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Kemp Eliminase KE07 著者 Jackson, C.J, Hong, N.-S, Carr, P.D. 登録日 2018-01-30 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 The evolution of multiple active site configurations in a designed enzyme. Nat Commun, 9, 2018
1CDE	STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE 分子名称: 5-DEAZAFOLIC ACID, GLYCINAMIDE RIBONUCLEOTIDE, PHOSPHORIBOSYL-GLYCINAMIDE FORMYLTRANSFERASE 著者 Almassy, R.J, Janson, C.A, Kan, C.-C, Hostomska, Z. 登録日 1992-05-15 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase. Proc.Natl.Acad.Sci.USA, 89, 1992
6C7T	Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 20 round 5 分子名称: Kemp Eliminase KE07 著者 Jackson, C.J, Hong, N.-S, Carr, P.D. 登録日 2018-01-23 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 The evolution of multiple active site configurations in a designed enzyme. Nat Commun, 9, 2018
8PBG	Mutant K1556T of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBP	Mutant R1785C of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBE	Mutant K1556T of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBI	Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBM	Mutant R1789Q of the dihydroorotase domain of human CAD protein bound to the substrate dihydroorotate 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBQ	Mutant R1810Q of the dihydroorotase domain of human CAD protein bound to the substrates 分子名称: CAD protein, FORMIC ACID, N-CARBAMOYL-L-ASPARTATE, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBR	Mutant R1475Q of the dihydroorotase domain of human CAD protein in apo form 分子名称: CAD protein, FORMIC ACID, ZINC ION 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBJ	Mutant R1722W of the dihydroorotase domain of human CAD protein bound to the substrate carbamoyl aspartate 分子名称: CAD protein, FORMIC ACID, GLYCEROL, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023
8PBN	Mutant R1789Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 del Cano-Ochoa, F, Ramon-Maiques, S. 登録日 2023-06-09 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Beyond genetics: Deciphering the impact of missense variants in CAD deficiency. J Inherit Metab Dis, 46, 2023

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