2D4Q
 
 | | Crystal structure of the Sec-PH domain of the human neurofibromatosis type 1 protein | | 分子名称: | Neurofibromin, OXTOXYNOL-10, PYROPHOSPHATE 2- | | 著者 | D'angelo, I, Welti, S, Bonneau, F, Scheffzek, K. | | 登録日 | 2005-10-22 | | 公開日 | 2006-03-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein
Embo Rep., 7, 2006
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4GWU
 | | Crystal Structure of Fru 2,6-bisphosphate complexes of Porcine Liver Fructose-1,6-bisphosphatase with Filled Central Cavity | | 分子名称: | 2,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase 1, MAGNESIUM ION | | 著者 | Gao, Y, Honzatko, R.B. | | 登録日 | 2012-09-03 | | 公開日 | 2013-09-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Hydrophobic Central Cavity in Fructose-1,6-bisphosphatase is Essential for the Synergism in AMP/Fru 2,6-bisphosphate Inhibition
To be Published
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3V5A
 | | Crystal Structure of C-lobe of Bovine Lactoferrin Complexed with Gamma Amino Butyric Acid at 1.44 A Resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-TERMINAL PEPTIDE OF LACTOTRANSFERRIN, ... | | 著者 | Shukla, P.K, Gautam, L, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. | | 登録日 | 2011-12-16 | | 公開日 | 2011-12-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Crystal Structure of C-lobe of Bovine Lactoferrin Complexed with Gamma Amino Butyric Acid at 1.44 A Resolution
To be Published
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1EAQ
 | | The RUNX1 Runt domain at 1.25A resolution: A structural switch and specifically bound chloride ions modulate DNA binding | | 分子名称: | CHLORIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | | 著者 | Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T, Grundstrom, T, Sauer, U.H. | | 登録日 | 2001-07-14 | | 公開日 | 2002-09-12 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
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2NY7
 | | HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY b12, HEAVY CHAIN, ... | | 著者 | Zhou, T, Xu, L, Dey, B, Hessell, A.J, Van Ryk, D, Xiang, S.H, Yang, X, Zhang, M.Y, Zwick, M.B, Arthos, J, Burton, D.R, Dimitrov, D.S, Sodroski, J, Wyatt, R, Nabel, G.J, Kwong, P.D. | | 登録日 | 2006-11-20 | | 公開日 | 2007-02-06 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Nature, 445, 2007
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1E6J
 | | Crystal structure of HIV-1 capsid protein (p24) in complex with Fab13B5 | | 分子名称: | CAPSID PROTEIN P24, IMMUNOGLOBULIN | | 著者 | Berthet-Colominas, C, Monaco, S, Novelli, A, Sibai, G, Mallet, F, Cusack, S. | | 登録日 | 2000-08-18 | | 公開日 | 2000-11-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Mutual Conformational Adaptations in Antigen and Antibody Upon Complex Formation between an Fab and HIV-1 Capsid Protein P24
Structure, 8, 2000
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4A9H
 | | N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one | | 分子名称: | (2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE, 1,2-ETHANEDIOL, BROMODOMAIN-CONTAINING PROTEIN 2, ... | | 著者 | Chung, C.W, Bamborough, P. | | 登録日 | 2011-11-26 | | 公開日 | 2012-01-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery.
J.Med.Chem., 55, 2012
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2WJ2
 | | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole | | 分子名称: | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, FATTY ACID AMIDE HYDROLASE 1 | | 著者 | Mileni, M, Garfunkle, J, DeMartino, J.K, Cravatt, B.F, Boger, D.L, Stevens, R.C. | | 登録日 | 2009-05-19 | | 公開日 | 2009-09-15 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures.
J.Am.Chem.Soc., 131, 2009
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2PHB
 | | An Orally Efficacious Factor Xa Inhibitor | | 分子名称: | (2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE, CALCIUM ION, Coagulation factor X, ... | | 著者 | Zhang, E, Kohrt, J.T, Bigge, C.F, Finzel, B.C. | | 登録日 | 2007-04-10 | | 公開日 | 2008-03-25 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor
Chem.Biol.Drug Des., 70, 2007
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3S3X
 | | Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive cation channel 2, neuronal, ... | | 著者 | Dawson, R.J.P, Benz, J, Stohler, P, Tetaz, T, Joseph, C, Huber, S, Schmid, G, Huegin, D, Pflimlin, P, Trube, G, Rudolph, M.G, Hennig, M, Ruf, A. | | 登録日 | 2011-05-18 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.
Nat Commun, 3, 2012
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2F5U
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7KC1
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2Q38
 | | Carbonic Anhydrase II in complex with Saccharin at 1.95 Angstrom | | 分子名称: | 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, BENZOIC ACID, Carbonic anhydrase 2, ... | | 著者 | Schulze Wischeler, J, Heine, A, Klebe, G. | | 登録日 | 2007-05-30 | | 公開日 | 2007-10-02 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Saccharin Inhibits Carbonic Anhydrases: Possible Explanation for its Unpleasant Metallic Aftertaste.
Angew.Chem.Int.Ed.Engl., 46, 2007
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3V96
 | | Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-1 (TIMP-1) | | 分子名称: | CALCIUM ION, Metalloproteinase inhibitor 1, PHOSPHATE ION, ... | | 著者 | Batra, J, Soares, A.S, Radisky, E.S. | | 登録日 | 2011-12-23 | | 公開日 | 2012-03-28 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
J.Biol.Chem., 287, 2012
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3NRA
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1G2V
 | | THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). TTP COMPLEX. | | 分子名称: | GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, THYMIDINE-5'-TRIPHOSPHATE | | 著者 | Blankenfeldt, W, Asuncion, M, Lam, J.S, Naismith, J.H. | | 登録日 | 2000-10-21 | | 公開日 | 2000-12-27 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA).
EMBO J., 19, 2000
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2FJ0
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1EAO
 | | THE RUNX1 Runt domain at 1.4A resolution: a structural switch and specifically bound chloride ions modulate DNA binding | | 分子名称: | BROMIDE ION, RUNT-RELATED TRANSCRIPTION FACTOR 1 | | 著者 | Backstrom, S, Wolf-Watz, M, Grundstrom, C, Hard, T.H, Grundstrom, T, Sauer, U.H. | | 登録日 | 2001-07-14 | | 公開日 | 2002-09-12 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The Runx1 Runt Domain at 1.25A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding
J.Mol.Biol., 322, 2002
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2OKC
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3N46
 | | Human FPPS complex with NOV_980 and zoledronic acid/MG2+ | | 分子名称: | (2R)-1-[(benzyloxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic acid, FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, ... | | 著者 | Rondeau, J.-M. | | 登録日 | 2010-05-21 | | 公開日 | 2010-08-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.
Nat.Chem.Biol., 6, 2010
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1RG8
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2FCX
 | | HIV-1 DIS kissing-loop in complex with neamine | | 分子名称: | (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, CHLORIDE ION, HIV-1 DIS RNA, ... | | 著者 | Ennifar, E, Paillart, J.C, Marquet, R, Dumas, P. | | 登録日 | 2005-12-13 | | 公開日 | 2006-05-16 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell.
Nucleic Acids Res., 34, 2006
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3N5D
 | | Crystal structure of the complex of type I ribosome inactivating protein with glucose at 1.9A resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ribosome inactivating protein, ... | | 著者 | Pandey, N, Kushwaha, G.S, Sinha, M, Kaur, P, Betzel, C, Sharma, S, Singh, T.P. | | 登録日 | 2010-05-25 | | 公開日 | 2010-06-30 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the complex of type I ribosome inactivating protein with glucose at 1.9A resolution
To be Published
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2Q7Z
 | | Solution Structure of the 30 SCR domains of human Complement Receptor 1 | | 分子名称: | Complement receptor type 1 | | 著者 | Furtado, P.B, Huang, C.Y, Ihyembe, D, Hammond, R.A, Marsh, H.C, Perkins, S.J. | | 登録日 | 2007-06-08 | | 公開日 | 2007-10-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | SOLUTION SCATTERING | | 主引用文献 | The Partly Folded Back Solution Structure Arrangement of the 30 SCR Domains in Human Complement Receptor Type 1 (CR1) Permits Access to its C3b and C4b Ligands
J.Mol.Biol., 375, 2008
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3S7I
 | | Crystal structure of Ara h 1 | | 分子名称: | Allergen Ara h 1, clone P41B, CHLORIDE ION | | 著者 | Chruszcz, M, Maleki, S.J, Solberg, R, Minor, W. | | 登録日 | 2011-05-26 | | 公開日 | 2011-09-21 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural and Immunologic Characterization of Ara h 1, a Major Peanut Allergen.
J.Biol.Chem., 286, 2011
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