Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4OIQ
DownloadVisualize
BU of 4oiq by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin
分子名称: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
著者Zhang, Y, Ebright, R.H, Arnold, E.
登録日2014-01-20
公開日2014-05-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.624 Å)
主引用文献GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIO
DownloadVisualize
BU of 4oio by Molmil
Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation
分子名称: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
著者Zhang, Y, Ebright, R.H, Arnold, E.
登録日2014-01-20
公開日2014-05-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4XLP
DownloadVisualize
BU of 4xlp by Molmil
Crystal structure of T.aquaticus transcription initiation complex containing upstream fork promoter
分子名称: DNA (25-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Bae, B, Darst, S.A.
登録日2015-01-13
公開日2015-09-23
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Elife, 4, 2015
4XSY
DownloadVisualize
BU of 4xsy by Molmil
Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme
分子名称: 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Bae, B, Darst, S.A.
登録日2015-01-22
公開日2015-07-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (4.007 Å)
主引用文献CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA, 112, 2015
4Q5S
DownloadVisualize
BU of 4q5s by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ...
著者Murakami, K.S.
登録日2014-04-17
公開日2014-07-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J.Biol.Chem., 289, 2014
4Q4Z
DownloadVisualize
BU of 4q4z by Molmil
Thermus thermophilus RNA polymerase de novo transcription initiation complex
分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ADENOSINE-5'-TRIPHOSPHATE, DNA (25-MER), ...
著者Murakami, K.S.
登録日2014-04-15
公開日2014-07-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J.Biol.Chem., 289, 2014
4OIN
DownloadVisualize
BU of 4oin by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077
分子名称: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
著者Zhang, Y, Ebright, R.H, Arnold, E.
登録日2014-01-20
公開日2014-05-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
7KHE
DownloadVisualize
BU of 7khe by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp
分子名称: CHAPSO, DNA (46-MER), DNA (54-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-21
公開日2020-12-09
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHB
DownloadVisualize
BU of 7khb by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter open complex
分子名称: CHAPSO, DNA (60-MER), DNA (64-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-20
公開日2020-10-28
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHC
DownloadVisualize
BU of 7khc by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter closed complex
分子名称: CHAPSO, DNA (18 MER), DNA (63-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-20
公開日2020-10-28
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7KHI
DownloadVisualize
BU of 7khi by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp
分子名称: CHAPSO, DNA (28-MER), DNA (36-MER), ...
著者Shin, Y, Qayyum, M.Z, Murakami, K.S.
登録日2020-10-21
公開日2020-10-28
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
4OIR
DownloadVisualize
BU of 4oir by Molmil
Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV
分子名称: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
著者Zhang, Y, Ebright, R.H, Arnold, E.
登録日2014-01-20
公開日2014-05-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.105 Å)
主引用文献GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
7KIF
DownloadVisualize
BU of 7kif by Molmil
Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor
分子名称: DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Lilic, M, Darst, S.A, Campbell, E.A.
登録日2020-10-23
公開日2021-04-21
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Mol.Cell, 81, 2021
7KIM
DownloadVisualize
BU of 7kim by Molmil
Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor
分子名称: DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Lilic, M, Darst, S.A, Campbell, E.A.
登録日2020-10-23
公開日2021-04-21
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Mol.Cell, 81, 2021
7KIN
DownloadVisualize
BU of 7kin by Molmil
Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter
分子名称: DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Lilic, M, Darst, S.A, Campbell, E.A.
登録日2020-10-23
公開日2021-04-21
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Mol.Cell, 81, 2021
7L7B
DownloadVisualize
BU of 7l7b by Molmil
Clostridioides difficile RNAP with fidaxomicin
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J.
登録日2020-12-28
公開日2022-02-02
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile.
Nature, 604, 2022
6LTS
DownloadVisualize
BU of 6lts by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex comprising a truncated sigma finger
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Zhang, Y, Ebright, R.H.
登録日2020-01-23
公開日2020-03-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
6M7J
DownloadVisualize
BU of 6m7j by Molmil
Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin
分子名称: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J.
登録日2018-08-20
公開日2018-11-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6N62
DownloadVisualize
BU of 6n62 by Molmil
Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A.
登録日2018-11-24
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.803 Å)
主引用文献Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6N4C
DownloadVisualize
BU of 6n4c by Molmil
EM structure of the DNA wrapping in bacterial open transcription initiation complex
分子名称: DNA (94-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Florez-Ariza, A, Cassago, A, de Oliveira, P.S.L, Guerra, D.G, Portugal, R.V.
登録日2018-11-19
公開日2020-05-27
実験手法ELECTRON MICROSCOPY (17 Å)
主引用文献Interactions of Upstream and Downstream Promoter Regions with RNA Polymerase are Energetically Coupled and a Target of Regulation in Transcription Initiation
Biorxiv, 2020
6N61
DownloadVisualize
BU of 6n61 by Molmil
Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Capistruin
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Capistruin, ...
著者Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A.
登録日2018-11-24
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.253 Å)
主引用文献Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6N57
DownloadVisualize
BU of 6n57 by Molmil
Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation I
分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A.
登録日2018-11-21
公開日2020-02-26
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation.
Elife, 8, 2019
7MLB
DownloadVisualize
BU of 7mlb by Molmil
Crystal structure of Thermus thermophilus transcription initiation complex with 5nt RNA
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*AP*GP*GP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*TP*GP*CP*AP*TP*CP*CP*CP*TP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Liu, Y, Ebright, R.H.
登録日2021-04-28
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural and mechanistic basis of reiterative transcription initiation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7MLJ
DownloadVisualize
BU of 7mlj by Molmil
Crystal structure of Thermus thermophilus reiterative transcription complex with 4nt oligo-G RNA
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*GP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*GP*CP*CP*CP*TP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Liu, Y, Ebright, R.H.
登録日2021-04-28
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.75 Å)
主引用文献Structural and mechanistic basis of reiterative transcription initiation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7MLI
DownloadVisualize
BU of 7mli by Molmil
Crystal structure of Thermus thermophilus reiterative transcription complex with 5nt oligo-C RNA
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*CP*TP*AP*CP*GP*GP*AP*TP*G)-3'), DNA (5'-D(P*CP*AP*TP*CP*CP*GP*TP*AP*GP*GP*GP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Liu, Y, Ebright, R.H.
登録日2021-04-28
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural and mechanistic basis of reiterative transcription initiation.
Proc.Natl.Acad.Sci.USA, 119, 2022

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon