4OIQ
| Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin | 分子名称: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | 著者 | Zhang, Y, Ebright, R.H, Arnold, E. | 登録日 | 2014-01-20 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.624 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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4OIO
| Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation | 分子名称: | 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... | 著者 | Zhang, Y, Ebright, R.H, Arnold, E. | 登録日 | 2014-01-20 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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4XLP
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4XSY
| Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme | 分子名称: | 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Bae, B, Darst, S.A. | 登録日 | 2015-01-22 | 公開日 | 2015-07-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.007 Å) | 主引用文献 | CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
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4Q5S
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4Q4Z
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4OIN
| Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 | 分子名称: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | 著者 | Zhang, Y, Ebright, R.H, Arnold, E. | 登録日 | 2014-01-20 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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7KHE
| Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp | 分子名称: | CHAPSO, DNA (46-MER), DNA (54-MER), ... | 著者 | Shin, Y, Qayyum, M.Z, Murakami, K.S. | 登録日 | 2020-10-21 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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7KHB
| Escherichia coli RNA polymerase and rrnBP1 promoter open complex | 分子名称: | CHAPSO, DNA (60-MER), DNA (64-MER), ... | 著者 | Shin, Y, Qayyum, M.Z, Murakami, K.S. | 登録日 | 2020-10-20 | 公開日 | 2020-10-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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7KHC
| Escherichia coli RNA polymerase and rrnBP1 promoter closed complex | 分子名称: | CHAPSO, DNA (18 MER), DNA (63-MER), ... | 著者 | Shin, Y, Qayyum, M.Z, Murakami, K.S. | 登録日 | 2020-10-20 | 公開日 | 2020-10-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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7KHI
| Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp | 分子名称: | CHAPSO, DNA (28-MER), DNA (36-MER), ... | 著者 | Shin, Y, Qayyum, M.Z, Murakami, K.S. | 登録日 | 2020-10-21 | 公開日 | 2020-10-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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4OIR
| Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV | 分子名称: | (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... | 著者 | Zhang, Y, Ebright, R.H, Arnold, E. | 登録日 | 2014-01-20 | 公開日 | 2014-05-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.105 Å) | 主引用文献 | GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
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7KIF
| Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor | 分子名称: | DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Lilic, M, Darst, S.A, Campbell, E.A. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
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7KIM
| Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor | 分子名称: | DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Lilic, M, Darst, S.A, Campbell, E.A. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
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7KIN
| Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter | 分子名称: | DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Lilic, M, Darst, S.A, Campbell, E.A. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
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7L7B
| Clostridioides difficile RNAP with fidaxomicin | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. | 登録日 | 2020-12-28 | 公開日 | 2022-02-02 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604, 2022
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6LTS
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6M7J
| Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin | 分子名称: | DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. | 登録日 | 2018-08-20 | 公開日 | 2018-11-21 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
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6N62
| Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. | 登録日 | 2018-11-24 | 公開日 | 2019-01-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.803 Å) | 主引用文献 | Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6N4C
| EM structure of the DNA wrapping in bacterial open transcription initiation complex | 分子名称: | DNA (94-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Florez-Ariza, A, Cassago, A, de Oliveira, P.S.L, Guerra, D.G, Portugal, R.V. | 登録日 | 2018-11-19 | 公開日 | 2020-05-27 | 実験手法 | ELECTRON MICROSCOPY (17 Å) | 主引用文献 | Interactions of Upstream and Downstream Promoter Regions with RNA Polymerase are Energetically Coupled and a Target of Regulation in Transcription Initiation Biorxiv, 2020
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6N61
| Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Capistruin | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Capistruin, ... | 著者 | Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. | 登録日 | 2018-11-24 | 公開日 | 2019-01-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.253 Å) | 主引用文献 | Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6N57
| Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation I | 分子名称: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | 登録日 | 2018-11-21 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation. Elife, 8, 2019
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7MLB
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7MLJ
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7MLI
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