1SEP
| MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND SEPIAPTERIN | 分子名称: | BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SEPIAPTERIN REDUCTASE | 著者 | Auerbach, G, Herrmann, A, Guetlich, M, Fischer, M, Jacob, U, Bacher, A, Huber, R. | 登録日 | 1997-05-23 | 公開日 | 1999-01-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. EMBO J., 16, 1997
|
|
1SO8
| Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)] | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type II, CHLORIDE ION, SODIUM ION | 著者 | Lustbader, J.W, Cirilli, M, Wu, H. | 登録日 | 2004-03-13 | 公開日 | 2004-05-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science, 304, 2004
|
|
4HFR
| Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with an orally bioavailable acidic inhibitor AZD4017. | 分子名称: | Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {(3S)-1-[5-(cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid | 著者 | Ogg, D.J, Gerhardt, S, Hargreaves, D. | 登録日 | 2012-10-05 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11 -Hydroxysteroid Dehydrogenase Type 1 (11 -HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017) J.Med.Chem., 55, 2012
|
|
4HBG
| |
4FD3
| |
4DYV
| Crystal structure of a short-chain dehydrogenase/reductase SDR from Xanthobacter autotrophicus Py2 | 分子名称: | CHLORIDE ION, Short-chain dehydrogenase/reductase SDR | 著者 | Agarwal, R, Chamala, S, Evans, B, Foti, R, Hillerich, B, Kar, A, Lafleur, J, Siedel, R, Villigas, G, Zencheck, W, Gizzi, A, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2012-02-29 | 公開日 | 2012-03-14 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a short-chain dehydrogenase/reductase SDR from Xanthobacter autotrophicus Py2 To be Published
|
|
1YO6
| |
5IDW
| |
5IG2
| |
5IDQ
| |
2BD0
| Chlorobium tepidum Sepiapterin Reductase complexed with NADP and Sepiapterin | 分子名称: | BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, sepiapterin reductase | 著者 | Supangat, S, Seo, K.H, Choi, Y.K, Park, Y.S, Lee, K.H. | 登録日 | 2005-10-19 | 公開日 | 2005-11-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin J.Biol.Chem., 281, 2006
|
|
5IF3
| |
5JO9
| Structural characterization of the thermostable Bradyrhizobium japonicum d-sorbitol dehydrogenase | 分子名称: | PHOSPHATE ION, Ribitol 2-dehydrogenase, sorbitol | 著者 | Fredslund, F, Otten, H, Navarro Poulsen, J.-C, Lo Leggio, L. | 登録日 | 2016-05-02 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | 主引用文献 | Structural characterization of the thermostable Bradyrhizobium japonicumD-sorbitol dehydrogenase. Acta Crystallogr F Struct Biol Commun, 72, 2016
|
|
1ZEM
| |
2C07
| Oxoacyl-ACP reductase of Plasmodium falciparum | 分子名称: | 3-OXOACYL-(ACYL-CARRIER PROTEIN) REDUCTASE, SULFATE ION | 著者 | Urch, J.E, Wickramasinghe, S.R, Inglis, K.A, Muller, S, Fairlamb, A.H, van Aalten, D.M.F. | 登録日 | 2005-08-26 | 公開日 | 2005-10-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Kinetic, Inhibition and Structural Studies on 3-Oxoacyl-Acp Reductase from Plasmodium Falciparum, a Key Enzyme in Fatty Acid Biosynthesis. Biochem.J., 393, 2006
|
|
5L4S
| Isopiperitenone reductase from Mentha piperita in complex with NADP and beta-Cyclocitral | 分子名称: | (-)-isopiperitenone reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, beta-cyclocitral | 著者 | Karuppiah, V, Toogood, H.S, Leys, D, Scrutton, N.S. | 登録日 | 2016-05-26 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases. Angew.Chem.Int.Ed.Engl., 55, 2016
|
|
1Z6Z
| Crystal Structure of Human Sepiapterin Reductase in complex with NADP+ | 分子名称: | CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... | 著者 | Ugochukwu, E, Kavanagh, K, Ng, S, Arrowsmith, C, Edwards, A, Sundstrom, M, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2005-03-23 | 公開日 | 2005-04-05 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of Human Sepiapterin Reductase To be Published
|
|
2BEL
| Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone | 分子名称: | CARBENOXOLONE, CHLORIDE ION, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, ... | 著者 | Kavanagh, K, Wu, X, Svensson, S, Elleby, B, von Delft, F, Debreczeni, J.E, Sharma, S, Bray, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Abrahmsen, L, Oppermann, U. | 登録日 | 2004-11-25 | 公開日 | 2004-12-06 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | The High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture To be Published
|
|
1ZBQ
| Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD | 分子名称: | 17-beta-hydroxysteroid dehydrogenase 4, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Lukacik, P, Shafqat, N, Kavanagh, K, Bray, J, von Delft, F, Edwards, A, Arrowsmith, C, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2005-04-08 | 公開日 | 2005-04-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD To be Published
|
|
6K8W
| |
8FD8
| human 15-PGDH with NADH bound | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 著者 | Huang, W, Taylor, D. | 登録日 | 2022-12-02 | 公開日 | 2023-03-08 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system. Nat Commun, 14, 2023
|
|
6K8U
| |
6K8V
| |
2PFG
| Crystal structure of human CBR1 in complex with BiGF2. | 分子名称: | (5R,10S)-5-{[(CARBOXYMETHYL)AMINO]CARBONYL}-7-OXO-3-THIA-1,6-DIAZABICYCLO[4.4.1]UNDECANE-10-CARBOXYLIC ACID, CHLORIDE ION, Carbonyl reductase [NADPH] 1, ... | 著者 | Rauh, D, Bateman, R.L, Shokat, K.M. | 登録日 | 2007-04-04 | 公開日 | 2007-09-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct. Org.Biomol.Chem., 5, 2007
|
|
6K8T
| |