PDB: 129 件ウェブページステータス検索Chemie searchBIRD

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8UQE	Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not modeled in density) 分子名称: E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E 著者 Hu, Q, Botuyan, M.V, Mer, G. 登録日 2023-10-23 公開日 2024-01-17 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.562 Å) 主引用文献 Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
8QTJ	Crystal structure of Cbl-b in complex with an allosteric inhibitor (compound 30) 分子名称: 3-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-1-[(1~{R})-1-(1-methylpyrazol-4-yl)ethyl]-5-(trifluoromethyl)pyridin-2-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ... 著者 Schimpl, M. 登録日 2023-10-12 公開日 2024-01-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.523 Å) 主引用文献 Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. J.Med.Chem., 67, 2024
8QTK	Crystal structure of CBL-b in complex with an allosteric inhibitor (compound 31) 分子名称: 3-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-1-[(1S)-1-(1-methylpyrazol-4-yl)ethyl]-5-(trifluoromethyl)pyridin-2-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ... 著者 Schimpl, M. 登録日 2023-10-12 公開日 2024-01-24 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.873 Å) 主引用文献 Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. J.Med.Chem., 67, 2024
7B5L	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 分子名称: 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-04 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021

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