7YZ6
 
 | | Molecular snapshots of drug release from tubulin: Dark (steady state) | | 分子名称: | Azo-Combretastatin A4 (cis), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | | 著者 | Wranik, M, Weinert, T, Standfuss, J. | | 登録日 | 2022-02-18 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
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7YYX
 | | Molecular snapshots of drug release from tubulin: 100 nanoseconds after photoactivation. | | 分子名称: | Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | | 著者 | Wranik, M, Weinert, T, Standfuss, J. | | 登録日 | 2022-02-18 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
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7YZ0
 | | Molecular snapshots of drug release from tubulin: 100 microseconds after photoactivation. | | 分子名称: | Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | | 著者 | Wranik, M, Weinert, T, Standfuss, J. | | 登録日 | 2022-02-18 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
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7YZ3
 | | Molecular snapshots of drug release from tubulin: Apo state | | 分子名称: | CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Wranik, M, Weinert, T, Standfuss, J. | | 登録日 | 2022-02-18 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
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7YYQ
 | | Molecular snapshots of drug release from tubulin: Dark state | | 分子名称: | Azo-Combretastatin A4 (cis), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | | 著者 | Wranik, M, Weinert, T, Standfuss, J. | | 登録日 | 2022-02-18 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
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7YYY
 | | Molecular snapshots of drug release from tubulin: 1 microsecond after photoactivation | | 分子名称: | Azo-Combretastatin A4 (trans), CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | | 著者 | Wranik, M, Weinert, T, Standfuss, J. | | 登録日 | 2022-02-18 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography.
Nat Commun, 14, 2023
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7TUB
 | | The beta-tubulin folding intermediate IV | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | 著者 | Zhao, Y, Frydman, J, Chiu, W. | | 登録日 | 2022-02-02 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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7TTN
 | | The beta-tubulin folding intermediate II | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | 著者 | Zhao, Y, Frydman, J, Chiu, W. | | 登録日 | 2022-02-01 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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7TTT
 | | The beta-tubulin folding intermediate III | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | 著者 | Zhao, Y, Frydman, J, Chiu, W. | | 登録日 | 2022-02-01 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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7TTD
 | | Tubulin-RB3_SLD in complex with compound 12e | | 分子名称: | 7-methoxy-4-[2-(morpholin-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-3,4-dihydroquinoxalin-2(1H)-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | White, S.W, Yun, M. | | 登録日 | 2022-02-01 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.
Acs Pharmacol Transl Sci, 6, 2023
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7TTF
 | | Tubulin-RB3_SLD in complex with compound 12k | | 分子名称: | 7-methoxy-4-[2-(methylamino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-3,4-dihydroquinoxalin-2(1H)-one, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | White, S.W, Yun, M. | | 登録日 | 2022-02-01 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.
Acs Pharmacol Transl Sci, 6, 2023
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7TTE
 | | Tubulin-RB3_SLD in complex with compound 12j | | 分子名称: | 4-[2-(cyclopropylamino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | White, S.W, Yun, M. | | 登録日 | 2022-02-01 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.
Acs Pharmacol Transl Sci, 6, 2023
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7TRG
 | | The beta-tubulin folding intermediate I | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | 著者 | Zhao, Y, Frydman, J, Chiu, W. | | 登録日 | 2022-01-28 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT.
Cell, 185, 2022
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7TR1
 | | CaKip3[2-436]-L2-mutant(HsKHC) - AMP-PNP in complex with a microtubule | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein,Kinesin-1 heavy chain, ... | | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J.S, Sosa, H. | | 登録日 | 2022-01-27 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
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7TR2
 | | Apo CaKip3[2-436]-L2-mutant(HsKHC) in complex with a microtubule | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein,Kinesin-1 heavy chain, ... | | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J.S, Sosa, H. | | 登録日 | 2022-01-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
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7TR3
 | | CaKip3[2-482] - AMP-PNP in complex with a dolastatin-10-stabilized tubulin ring | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J.S, Sosa, H. | | 登録日 | 2022-01-27 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
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7TQX
 | | CaKip3[2-482] - AMP-PNP in complex with a microtubule | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J, Sosa, H. | | 登録日 | 2022-01-27 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
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7TQY
 | | CaKip3[2-482] - ADP-AlFx in complex with a microtubule | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J, Sosa, H. | | 登録日 | 2022-01-27 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
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7TR0
 | | CaKip3[2-436] - AMP-PNP in complex with a microtubule | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J, Sosa, H. | | 登録日 | 2022-01-27 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
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7TQZ
 | | Apo CaKip3[2-482] in complex with a microtubule | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ... | | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J.S, Sosa, H. | | 登録日 | 2022-01-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
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7TNT
 | | The tubulin-based conoid from detergent-extract Toxoplasma gondii cells | | 分子名称: | Tubulin alpha chain, Tubulin beta chain | | 著者 | Sun, S.Y, Pintilie, G.D, Chen, M, Chiu, W. | | 登録日 | 2022-01-21 | | 公開日 | 2022-06-22 | | 実験手法 | ELECTRON MICROSCOPY (9.3 Å) | | 主引用文献 | Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7TNS
 | | Subpellicular microtubule from detergent-extract Toxoplasma gondii cells | | 分子名称: | Microtubule associated protein SPM1, PDI family protein, Tubulin alpha chain, ... | | 著者 | Sun, S.Y, Pintilie, G.D, Chen, M, Chiu, W. | | 登録日 | 2022-01-21 | | 公開日 | 2022-06-22 | | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | | 主引用文献 | Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7TNQ
 | | The symmetry-released subpellicular microtubule map from detergent-extracted Toxoplasma cells | | 分子名称: | Microtubule associated protein SPM1, PDI family protein, Tubulin alpha chain, ... | | 著者 | Sun, S.Y, Pintilie, G.D, Chen, M. | | 登録日 | 2022-01-21 | | 公開日 | 2022-06-22 | | 実験手法 | ELECTRON MICROSCOPY (8.4 Å) | | 主引用文献 | Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7QUQ
 | | BtubA(R284G,K286D,F287G):BtubB bacterial tubulin M-loop mutant forming a single protofilament (Prosthecobacter dejongeii) | | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Tubulin beta, Tubulin domain-containing protein | | 著者 | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | | 登録日 | 2022-01-18 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics.
Sci Adv, 9, 2023
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7QUP
 | | D. melanogaster 13-protofilament microtubule | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | | 登録日 | 2022-01-18 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics.
Sci Adv, 9, 2023
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