7TTD

Tubulin-RB3_SLD in complex with compound 12e

Summary for 7TTD

• Entry DOI: 10.2210/pdb7ttd/pdb
• Descriptor: Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total)
• Functional Keywords: microtubule inhibitor, colchicine, cell cycle, cancer, inhibitor complex, cell cycle-inhibitor complex, cell cycle/inhibitor
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 5
• Total formula weight: 214892.83

Authors

White, S.W.,Yun, M. (deposition date: 2022-02-01, release date: 2023-04-12, Last modification date: 2023-10-25)

• Primary citation: Pochampally, S.,Hartman, K.L.,Wang, R.,Wang, J.,Yun, M.K.,Parmar, K.,Park, H.,Meibohm, B.,White, S.W.,Li, W.,Miller, D.D.; Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.; Acs Pharmacol Transl Sci, 6:526-545, 2023; PubMed: 37082747; DOI: 10.1021/acsptsci.2c00108

Experimental method

X-RAY DIFFRACTION (2.27 Å)