PDB: 533 件ウェブページステータス検索Chemie searchBIRD

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6AMW	Abl1b Regulatory Module 'Activating' conformation 分子名称: Tyrosine-protein kinase ABL1 著者 Kalodimos, C.G, Rossi, P, Saleh, T. 登録日 2017-08-11 公開日 2017-09-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Atomic view of the energy landscape in the allosteric regulation of Abl kinase. Nat. Struct. Mol. Biol., 24, 2017
6AMV	Abl 1b Regulatory Module 'inhibiting state' 分子名称: Tyrosine-protein kinase ABL1 著者 Kalodimos, C.G, Saleh, T, Rossi, P. 登録日 2017-08-11 公開日 2017-09-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Atomic view of the energy landscape in the allosteric regulation of Abl kinase. Nat. Struct. Mol. Biol., 24, 2017
5OB0	Crystal structure of the c-Src-SH3 domain Q128E mutant in complex with the high affinity peptide APP12 分子名称: APP12, Proto-oncogene tyrosine-protein kinase Src, SULFATE ION 著者 Camara-Artigas, A. 登録日 2017-06-25 公開日 2017-07-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.172 Å) 主引用文献 Crystal structure of the c-Src-SH3 domain Q128E mutant in complex with the high affinity peptide APP12 to be published
5OB2	Crystal structure of the c-Src-SH3 domain E97T mutant in complex with the high affinity peptide APP12 分子名称: APP12, Proto-oncogene tyrosine-protein kinase Src 著者 Camara-Artigas, A. 登録日 2017-06-25 公開日 2017-07-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the c-Src-SH3 domain E97T mutant in complex with the high affinity peptide APP12 to be published
5OAZ	Crystal structure of the Abl-SH3 domain at pH 7.5 分子名称: DI(HYDROXYETHYL)ETHER, Tyrosine-protein kinase ABL1 著者 Camara-Artigas, A. 登録日 2017-06-25 公開日 2017-07-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 Crystal structure of the Abl-SH3 domain at pH 7.5 to be published
5OB1	Crystal structure of the c-Src-SH3 domain Q128R mutant in complex with the high affinity peptide APP12 分子名称: APP12, Proto-oncogene tyrosine-protein kinase Src 著者 Camara-Artigas, A. 登録日 2017-06-25 公開日 2017-07-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.172 Å) 主引用文献 Crystal structure of the c-Src-SH3 domain Q128R mutant in complex with the high affinity peptide APP12 to be published
5OAV	High resolution crystal structure of the c-Src-SH3 domain mutant E93V in complex with the high affinity synthetic peptide APP12: monoclinic crystal 分子名称: APP12, Proto-oncogene tyrosine-protein kinase Src 著者 Camara-Artigas, A. 登録日 2017-06-23 公開日 2017-07-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (0.95 Å) 主引用文献 High resolution crystal structure of the c-Src-SH3 domain mutant E93V in complex with the high affinity synthetic peptide APP12: monoclinic crystal to be published
5O2P	p130Cas SH3 domain PTP-PEST peptide chimera 分子名称: Breast cancer anti-estrogen resistance 1,Tyrosine-protein phosphatase non-receptor type 12 著者 Hexnerova, R, Veverka, V. 登録日 2017-05-22 公開日 2017-09-20 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep, 7, 2017
5O2Q	p130Cas SH3 domain Vinculin peptide chimera 分子名称: Breast cancer anti-estrogen resistance 1,Vinculin 著者 Hexnerova, R, Veverka, V. 登録日 2017-05-22 公開日 2017-09-20 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep, 7, 2017
5O2M	p130Cas SH3 domain 分子名称: Breast cancer anti-estrogen resistance 1 著者 Hexnerova, R, Veverka, V. 登録日 2017-05-22 公開日 2017-09-20 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep, 7, 2017
5NUH	Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain 分子名称: Protein Nef, Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK 著者 Horenkamp, F.A, Anand, K, Geyer, M. 登録日 2017-04-30 公開日 2017-08-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat Commun, 8, 2017
5XGG	Crystal Structure C-terminal SH3 domain of Myosin IB from Entamoeba histolytica 分子名称: SULFATE ION, Unconventional myosin IB 著者 Gautam, G, Gourinath, S. 登録日 2017-04-13 公開日 2017-08-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Crystal structure of the PEG-bound SH3 domain of myosin IB from Entamoeba histolytica reveals its mode of ligand recognition Acta Crystallogr D Struct Biol, 73, 2017
5NP2	Abl1 SH3 pTyr89/134 分子名称: Tyrosine-protein kinase ABL1 著者 Mero, B, Radnai, L, Gogl, G, Leveles, I, Buday, L. 登録日 2017-04-13 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions. J.Biol.Chem., 294, 2019
5NP3	Abl2 SH3 分子名称: Abelson tyrosine-protein kinase 2 著者 Mero, B, Radnai, L, Gogl, G, Leveles, I, Buday, L. 登録日 2017-04-13 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions. J.Biol.Chem., 294, 2019
5XG9	Crystal Structure of PEG-bound SH3 domain of Myosin IB from Entamoeba histolytica 分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, PENTAETHYLENE GLYCOL, ... 著者 Gautam, G, Gourinath, S. 登録日 2017-04-13 公開日 2017-08-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Crystal structure of the PEG-bound SH3 domain of myosin IB from Entamoeba histolytica reveals its mode of ligand recognition Acta Crystallogr D Struct Biol, 73, 2017
5NP5	Abl2 SH3 pTyr116/161 分子名称: Abelson tyrosine-protein kinase 2, SULFATE ION 著者 Mero, B, Radnai, L, Gogl, G, Leveles, I, Buday, L. 登録日 2017-04-13 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions. J.Biol.Chem., 294, 2019
5VEI	Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2 分子名称: Sorbin and SH3 domain-containing protein 2, UNKNOWN ATOM OR ION 著者 Liu, Y, Tempel, W, Huang, H, Gu, J, Liu, K, Sidhu, S.S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2017-04-04 公開日 2017-08-02 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Crystal structure of the SH3 domain of human sorbin and SH3 domain-containing protein 2 To be Published
5UL6	The molecular mechanisms by which NS1 of the 1918 Spanish influenza A virus hijack host protein-protein interactions 分子名称: Adapter molecule crk, Proline-rich motif of nonstructural protein 1 of influenza a virus 著者 Shen, Q, Zeng, D, Zhao, B, Li, P, Cho, J.H. 登録日 2017-01-24 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The Molecular Mechanisms Underlying the Hijack of Host Proteins by the 1918 Spanish Influenza Virus. ACS Chem. Biol., 12, 2017
5MO4	ABL1 kinase (T334I_D382N) in complex with asciminib and nilotinib 分子名称: Nilotinib, Tyrosine-protein kinase ABL1, asciminib 著者 Cowan-Jacob, S.W. 登録日 2016-12-13 公開日 2017-04-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. Nature, 543, 2017
5H09	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-ethyl2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoate 分子名称: Tyrosine-protein kinase HCK, ethyl (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate 著者 Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. 登録日 2016-10-04 公開日 2017-10-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.945 Å) 主引用文献 Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg. Med. Chem., 25, 2017
5H0B	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoic acid 分子名称: (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate, Tyrosine-protein kinase HCK 著者 Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. 登録日 2016-10-04 公開日 2017-10-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.651 Å) 主引用文献 Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg. Med. Chem., 25, 2017
5H0E	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanamide 分子名称: (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide, Tyrosine-protein kinase HCK 著者 Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. 登録日 2016-10-04 公開日 2017-10-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg. Med. Chem., 25, 2017
5H0H	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,N,4-trimethylpentanamide 分子名称: (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},~{N},4-trimethyl-pentanamide, Tyrosine-protein kinase HCK 著者 Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. 登録日 2016-10-04 公開日 2017-10-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg. Med. Chem., 25, 2017
5H0G	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor (S)-2-(((1r,4S)-4-(4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexyl)amino)-N,4-dimethylpentanamide 分子名称: (2~{S})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{N},4-dimethyl-pentanamide, Tyrosine-protein kinase HCK 著者 Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. 登録日 2016-10-04 公開日 2017-10-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen. Bioorg. Med. Chem., 25, 2017
5L23	Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand 分子名称: Adapter molecule crk, C3G derived peptide, DI(HYDROXYETHYL)ETHER 著者 Bhatt, V.S, Krieger, I, Sacchettini, J, Cho, J.-H. 登録日 2016-07-30 公開日 2016-09-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand To Be Published

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