PDB: 595 件ウェブページステータス検索Chemie searchBIRD

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3US4	Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution 分子名称: Megakaryocyte-associated tyrosine-protein kinase, SULFATE ION 著者 Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) 登録日 2011-11-22 公開日 2011-12-28 最終更新日 2023-02-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution To be published
1CWD	HUMAN P56LCK TYROSINE KINASE COMPLEXED WITH PHOSPHOPEPTIDE 分子名称: (PHOSPHONOMETHYL)PHENYLALANINE-CONTAINING PEPTIDE PRO-GLU-GLY-ASP-PM3-GLU-GLU-VAL-LEU, P56LCK TYROSINE KINASE 著者 Mikol, V. 登録日 1995-09-06 公開日 1996-12-07 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site. J.Mol.Biol., 246, 1995
1CSZ	SYK TYROSINE KINASE C-TERMINAL SH2 DOMAIN COMPLEXED WITH A PHOSPHOPEPTIDEFROM THE GAMMA CHAIN OF THE HIGH AFFINITY IMMUNOGLOBIN G RECEPTOR, NMR 分子名称: ACETYL-THR-PTR-GLU-THR-LEU-NH2, SYK PROTEIN TYROSINE KINASE 著者 Narula, S.S, Yuan, R.W, Adams, S.E, Green, O.M, Green, J, Phillips, T.B, Zydowsky, L.D, Botfield, M.C, Hatada, M.H, Laird, E.R, Zoller, M.J, Karas, J.L, Dalgarno, D.C. 登録日 1995-10-03 公開日 1996-11-08 最終更新日 2024-06-05 実験手法 SOLUTION NMR 主引用文献 Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide. Structure, 3, 1995
3UYO	Crystal structure of monobody SH13/ABL1 SH2 domain complex 分子名称: Monobody SH13, SULFATE ION, Tyrosine-protein kinase ABL1 著者 Wojcik, J.B, Koide, A, Koide, S. 登録日 2011-12-06 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J.Mol.Biol., 415, 2012
1FBZ	Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK, {4-[2-ACETYLAMINO-2-(3-CARBAMOYL-2-CYCLOHEXYLMETHOXY-6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTEN-5YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENYL}-PHOSPHONIC ACID 著者 Shakespeare, W, Yang, M, Bohacek, R, Cerasoli, F, Stebbis, K, Sundaramoorthi, R, Vu, C, Pradeepan, S, Metcalf, C, Haraldson, C, Merry, T, Dalgarno, D, Narula, S, Hatada, M, Lu, X, Van Schravendijk, M.R, Adams, S, Violette, S, Smith, J, Guan, W, Bartlett, C, Herson, J, Iuliucci, J, Weigele, M, Sawyer, T. 登録日 2000-07-17 公開日 2000-08-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc.Natl.Acad.Sci.Usa, 97, 2000
1TZE	SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2) 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 著者 Rahuel, J, Grutter, M.G. 登録日 1996-06-06 公開日 1997-07-07 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode. Nat.Struct.Biol., 3, 1996
1FHS	THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES 分子名称: GROWTH FACTOR RECEPTOR BOUND PROTEIN-2 著者 Senior, M.M, Frederick, A.F, Black, S, Perkins, L.M, Wilson, O, Snow, M.E, Wang, Y.-S. 登録日 1997-06-12 公開日 1998-06-17 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The three-dimensional solution structure of the Src homology domain-2 of the growth factor receptor-bound protein-2. J.Biomol.NMR, 11, 1998
1FU5	NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE COMPLEXED TO A DOUBLY PHOSPHORYLATED PEPTIDE DERIVED FROM POLYOMAVIRUS MIDDLE T ANTIGEN 分子名称: DOUBLY PHOSPHORYLATED MIDDLE T ANTIGEN, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 著者 Weber, T, Schaffhausen, B, Liu, Y, Guenther, U.L. 登録日 2000-09-14 公開日 2001-02-21 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site. Biochemistry, 39, 2000
3WA4	Grb2 SH2 domain/CD28-derived peptide complex 分子名称: ACETIC ACID, CADMIUM ION, Growth factor receptor-bound protein 2, ... 著者 Higo, K, Oda, M, Ito, N. 登録日 2013-04-23 公開日 2014-02-26 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28 Plos One, 8, 2013
1FYR	DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE 著者 Schiering, N, Casale, E, Caccia, P, Giordano, P, Battistini, C. 登録日 2000-10-03 公開日 2000-12-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex. Biochemistry, 39, 2000
1SPR	BINDING OF A HIGH AFFINITY PHOSPHOTYROSYL PEPTIDE TO THE SRC SH2 DOMAIN: CRYSTAL STRUCTURES OF THE COMPLEXED AND PEPTIDE-FREE FORMS 分子名称: PHOSPHATE ION, SRC TYROSINE KINASE SH2 DOMAIN 著者 Waksman, G, Kuriyan, J. 登録日 1993-03-05 公開日 1994-05-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell(Cambridge,Mass.), 72, 1993
1GHU	NMR solution structure of growth factor receptor-bound protein 2 (GRB2) SH2 domain, 24 structures 分子名称: GRB2 著者 Thornton, K.H, Mueller, W.T, Mcconnell, P, Zhu, G, Saltiel, A.R, Thanabal, V. 登録日 1996-08-05 公開日 1997-01-27 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain. Biochemistry, 35, 1996
1H9O	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A 分子名称: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE 著者 Pauptit, R.A, Rowsell, S, Breeze, A.L, Murshudov, G.N, Dennis, C.A, Derbyshire, D.J, Weston, S.A. 登録日 2001-03-14 公開日 2001-03-19 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex Acta Crystallogr.,Sect.D, 57, 2001
1HCT	NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX 分子名称: ACETYL-PYEEIE-OH, HUMAN SRC 著者 Gampe Junior, R.T, Xu, R.X. 登録日 1994-09-02 公開日 1995-09-15 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide. Biochemistry, 34, 1995
1HCS	NMR STRUCTURE OF THE HUMAN SRC SH2 DOMAIN COMPLEX 分子名称: ACETYL-PYEEIE-OH, HUMAN SRC 著者 Gampe Junior, R.T, Xu, R.X. 登録日 1994-09-02 公開日 1995-09-15 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide. Biochemistry, 34, 1995
1F1W	SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, S(PTR)VNVQN PHOSPHOPEPTIDE 著者 Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. 登録日 2000-05-20 公開日 2000-07-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for specificity switching of the Src SH2 domain. Mol.Cell, 5, 2000
1F2F	SRC SH2 THREF1TRP MUTANT 分子名称: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Kimber, M.S, Nachman, J, Cunningham, A.M, Gish, G.D, Pawson, T, Pai, E.F. 登録日 2000-05-24 公開日 2000-07-06 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for specificity switching of the Src SH2 domain. Mol.Cell, 5, 2000
2GE9	Solution Structures of the SH2 domain of Bruton's Tyrosine Kinase 分子名称: Tyrosine-protein kinase BTK 著者 Cheng, J.-W, Huang, K.-C. 登録日 2006-03-18 公開日 2006-10-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase J.Biomol.Nmr, 36, 2006
2IUH	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with c-Kit phosphotyrosyl peptide 分子名称: C-KIT PHOSPHOTYROSYL PEPTIDE, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 著者 Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. 登録日 2006-06-03 公開日 2006-06-06 最終更新日 2021-04-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
2IUG	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 著者 Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. 登録日 2006-06-03 公開日 2006-06-06 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
2IUI	Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta 著者 Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. 登録日 2006-06-03 公開日 2006-06-06 最終更新日 2021-04-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes Nat.Struct.Biol., 3, 1996
2JYQ	NMR structure of the apo v-Src SH2 domain 分子名称: Tyrosine-protein kinase transforming protein Src 著者 Taylor, J.D, Ababou, A, Williams, M.A, Ladbury, J.E. 登録日 2007-12-17 公開日 2008-06-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design Proteins, 73, 2008
2HUW	X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand 分子名称: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION 著者 Benfield, A.P, Martin, S.F. 登録日 2006-07-27 公開日 2006-08-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 45, 2006
2HMH	Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. 分子名称: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3 著者 Bergamin, E, Wu, J, Hubbard, S.R. 登録日 2006-07-11 公開日 2006-08-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Structure, 14, 2006
2KK6	Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d 分子名称: Proto-oncogene tyrosine-protein kinase FER 著者 Tang, Y, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2009-06-15 公開日 2009-08-11 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d To be Published

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