PDB: 36939 件ウェブページステータス検索Chemie searchBIRD

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4CKA	STEROL 14-ALPHA DEMETHYLASE (CYP51)FROM TRYPANOSOMA CRUZI IN COMPLEX WITH (S)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 4- isopropylphenylcarbamate (LFS) 分子名称: (1S)-1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)ethyl 4-isopropylphenylcarbamate, PROTOPORPHYRIN IX CONTAINING FE, STEROL 14-ALPHA DEMETHYLASE 著者 Friggeri, L, Wawrzak, Z, Tortorella, S, Lepesheva, G.I. 登録日 2013-12-31 公開日 2014-07-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma Cruzi Sterol 14Alpha-Demethylase: Two Regions of the Enzyme Molecule Potentiate its Inhibition. J.Med.Chem., 57, 2014
3OIV	H-RasG12V with allosteric switch in the "off" state 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GTPase HRas, ... 著者 Buhrman, G, Mattos, C. 登録日 2010-08-20 公開日 2010-12-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.837 Å) 主引用文献 Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286, 2011
4EP6	Crystal structure of the XplA heme domain in complex with imidazole and PEG 分子名称: Cytochrome P450-like protein XplA, IMIDAZOLE, PENTAETHYLENE GLYCOL, ... 著者 Bui, S.H, McLean, K.J, Cheesman, M.R, Bradley, J.M, Rigby, S.E.J, Leys, D, Munro, A.W. 登録日 2012-04-17 公開日 2012-05-09 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA. J.Biol.Chem., 287, 2012
6FSJ	Crystal structure of TCE-treated Lysozyme 分子名称: 1,2-ETHANEDIOL, CITRIC ACID, Lysozyme C 著者 Pichlo, C, Baumann, U. 登録日 2018-02-19 公開日 2018-05-02 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Improved protein-crystal identification by using 2,2,2-trichloroethanol as a fluorescence enhancer. Acta Crystallogr F Struct Biol Commun, 74, 2018
4EQ0	Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC 分子名称: 1,2-ETHANEDIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ... 著者 Schiffer, C.A, Mittal, S. 登録日 2012-04-17 公開日 2012-06-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci., 21, 2012
3OOZ	Bace1 in complex with the aminohydantoin Compound 102 分子名称: (5R)-2-amino-5-[4-(difluoromethoxy)phenyl]-5-[4-fluoro-3-(5-fluoropent-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Beta-secretase 1 著者 Olland, A.M. 登録日 2010-08-31 公開日 2011-08-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Design and Synthesis of Aminohydantoins as Potent and Selective Human beta-Secretase (BACE1) Inhibitors with Enhanced Brain Permeability Bioorg.Med.Chem.Lett., 20, 2010
6FTY	COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5 分子名称: 4-[[(5~{S},7~{R})-3-azanyl-1-adamantyl]carbonylamino]-1~{H}-indole-2-carboxamide, Complement factor D, GLYCEROL 著者 Ostermann, N. 登録日 2018-02-26 公開日 2018-06-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett, 9, 2018
4EX1	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-04-29 公開日 2013-05-01 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.657 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
3OUB	MDR769 HIV-1 protease complexed with NC/p1 hepta-peptide 分子名称: MDR HIV-1 protease, NC/p1 substrate peptide 著者 Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. 登録日 2010-09-14 公開日 2011-03-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease. Protein J., 30, 2011
4EXZ	Crystal Structure of the Q108K:K40L Mutant of Cellular Retinol Binding Protein Type II in Complex with All-trans-Retinal at 1.7 Angstrom Resolution 分子名称: ACETATE ION, RETINAL, Retinol-binding protein 2 著者 Nossoni, Z, Geiger, J.H. 登録日 2012-05-01 公開日 2012-12-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.608 Å) 主引用文献 Tuning the electronic absorption of protein-embedded all-trans-retinal. Science, 338, 2012
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN 著者 Clements, J.H, Martin, S.F. 登録日 2010-09-16 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
4EY9	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-05-01 公開日 2013-05-01 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.471 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4EYD	Human Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Favero-Retto, M.P, Palmieri, L.C, Lima, L.M.T.R. 登録日 2012-05-01 公開日 2013-05-01 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.471 Å) 主引用文献 Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013
4E89	Crystal Structure of RnaseH from gammaretrovirus 分子名称: CADMIUM ION, MAGNESIUM ION, RNase H 著者 Kim, J.H, Kim, S.J. 登録日 2012-03-19 公開日 2012-10-17 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H Biosci.Rep., 32, 2012
6E04	sperm whale myoglobin 1-nitrosopropane 分子名称: 1-nitrosopropane, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Herrera, V.E. 登録日 2018-07-06 公開日 2019-07-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Insights into Nitrosoalkane Binding to Myoglobin Provided by Crystallography of Wild-Type and Distal Pocket Mutant Derivatives. Biochemistry, 62, 2023
4EGP	The X-ray crystal structure of CYP199A4 in complex with 2-naphthoic acid 分子名称: CHLORIDE ION, Cytochrome P450, GLYCEROL, ... 著者 Zhou, W, Bell, S.G, Yang, W, Zhou, R.M, Tan, A.B.H, Wong, L.-L. 登録日 2012-03-31 公開日 2013-02-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering Chemistry, 18, 2012
4EB1	Hyperstable in-frame insertion variant of antithrombin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III 著者 Martinez-Martinez, I, Johnson, D.J.D, Yamasaki, M, Corral, J, Huntington, J.A. 登録日 2012-03-23 公開日 2012-07-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance. J.Thromb.Haemost., 10, 2012
3P3X	Crystal Structure of the Cytochrome P450 Monooxygenase AurH (nterm-AurH-I) from Streptomyces Thioluteus 分子名称: CHLORIDE ION, Cytochrome P450, GLYCEROL, ... 著者 Zocher, G, Richter, M.E.A, Mueller, U, Hertweck, C. 登録日 2010-10-05 公開日 2011-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural fine-tuning of a multifunctional cytochrome p450 monooxygenase. J.Am.Chem.Soc., 133, 2011
3ONZ	Human tetrameric hemoglobin: proximal nitrite ligand at beta 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRITE ION, ... 著者 Yi, J, Thormas, L.M, Safo, M.K, Musayev, F.N, Richter-Addo, G.B. 登録日 2010-08-30 公開日 2011-09-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.087 Å) 主引用文献 Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin. Biochemistry, 50, 2011
3OO5	R-state human hemoglobin: nitriheme modified 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, NITRITE ION, ... 著者 Yi, J, Thormas, L.M, Richter-Addo, G.B. 登録日 2010-08-30 公開日 2011-09-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystallographic Trapping of Heme Loss Intermediates during the Nitrite-Induced Degradation of Human Hemoglobin. Biochemistry, 50, 2011
4EK1	Crystal Structure of Electron-Spin Labeled Cytochrome P450cam 分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... 著者 Lee, Y.-T, Goodin, D.B. 登録日 2012-04-08 公開日 2012-07-25 最終更新日 2012-08-29 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Double electron-electron resonance shows cytochrome P450cam undergoes a conformational change in solution upon binding substrate. Proc.Natl.Acad.Sci.USA, 109, 2012
3P4L	Crystal structure of a hemojuvelin-binding fragment of neogenin 分子名称: Neogenin 著者 Yang, F, West Jr, A.P, Bjorkman, P.J. 登録日 2010-10-06 公開日 2010-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8A. J.Struct.Biol., 174, 2011
6E3Z	Structure of Bace-1 in complex with Ligand 8 分子名称: Beta-secretase 1, N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-3,5-dichloropyridine-2-carboxamide 著者 Shaffer, P.L. 登録日 2018-07-16 公開日 2019-09-11 最終更新日 2020-03-25 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Discovery and Chemical Development of JNJ-50138803, a Clinical Candidate BACE1 Inhibitor Acs Symp.Ser., 1307, 2020
3OUD	MDR769 HIV-1 protease complexed with CA/p2 hepta-peptide 分子名称: CA/p2 substrate peptide, MDR HIV-1 protease 著者 Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C. 登録日 2010-09-14 公開日 2011-03-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease. Protein J., 30, 2011
3P5G	Structure of the carbohydrate-recognition domain of human Langerin with Blood group B trisaccharide (Gal alpha1-3(Fuc alpha1-2)Gal) 分子名称: C-type lectin domain family 4 member K, CALCIUM ION, alpha-L-fucopyranose, ... 著者 Feinberg, H, Taylor, M.E, Razi, N, McBride, R, Knirel, Y.A, Graham, S.A, Drickamer, K, Weis, W.I. 登録日 2010-10-08 公開日 2010-12-08 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.6027 Å) 主引用文献 Structural Basis for Langerin Recognition of Diverse Pathogen and Mammalian Glycans through a Single Binding Site. J.Mol.Biol., 405, 2011

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