8CZ4
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![BU of 8cz4 by Molmil](/molmil-images/mine/8cz4) | Crystal structure of SARS-CoV-2 Mpro with compound C3 | 分子名称: | 3C-like proteinase, N-(4-tert-butylphenyl)-N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)acetamide | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | 登録日 | 2022-05-24 | 公開日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerg Microbes Infect, 12, 2023
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7P1Z
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![BU of 7p1z by Molmil](/molmil-images/mine/7p1z) | Novel GH12 endogluconase from Aspergillus cervinus | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, Glycoside hydrolase, ... | 著者 | Lazarenko, V.A, Rykov, S.V, Nikolaeva, A.Y, Berezina, O.V, Akentyev, F.I. | 登録日 | 2021-07-03 | 公開日 | 2021-07-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Unusual substrate specificity in GH family 12: structure-function analysis of glucanases Bgh12A and Xgh12B from Aspergillus cervinus, and Egh12 from Thielavia terrestris. Appl.Microbiol.Biotechnol., 106, 2022
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8CRC
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![BU of 8crc by Molmil](/molmil-images/mine/8crc) | Structure of human Plk1 PBD in complex with Allopole-A | 分子名称: | 7-chloro-4-(cyclopropylmethyl)-1-thioxo-2,4-dihydrothieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one, GLYCEROL, Serine/threonine-protein kinase PLK1 | 著者 | Kirsch, K, Park, J.E, Lee, K.S. | 登録日 | 2023-03-08 | 公開日 | 2023-08-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition. Proc.Natl.Acad.Sci.USA, 120, 2023
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6PGF
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5AKC
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![BU of 5akc by Molmil](/molmil-images/mine/5akc) | MutS in complex with the N-terminal domain of MutL - crystal form 2 | 分子名称: | DNA MISMATCH REPAIR PROTEIN MUTL, DNA MISMATCH REPAIR PROTEIN MUTS, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Groothuizen, F.S, Winkler, I, Cristovao, M, Fish, A, Winterwerp, H.H.K, Reumer, A, Marx, A.D, Hermans, N, Nicholls, R.A, Murshudov, G.N, Lebbink, J.H.G, Friedhoff, P, Sixma, T.K. | 登録日 | 2015-03-03 | 公開日 | 2015-07-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (6.6 Å) | 主引用文献 | MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA. Elife, 4, 2015
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6AZH
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8PMG
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![BU of 8pmg by Molmil](/molmil-images/mine/8pmg) | Structure of Nal1 indica cultivar IR64, construct 36-458 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Huang, L.Y, Rety, S, Xi, X.G. | 登録日 | 2023-06-28 | 公開日 | 2024-04-17 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | The catalytic triad of rice NARROW LEAF1 involves H234. Nat.Plants, 10, 2024
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7ONO
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6MGP
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![BU of 6mgp by Molmil](/molmil-images/mine/6mgp) | Structure of human 4-1BB / 4-1BBL complex | 分子名称: | ACETATE ION, GLYCEROL, Tumor necrosis factor ligand superfamily member 9, ... | 著者 | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | 登録日 | 2018-09-14 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab Nat Commun, 9, 2018
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6AZQ
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![BU of 6azq by Molmil](/molmil-images/mine/6azq) | Structural and biochemical characterization of a non-canonical biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841 | 分子名称: | CALCIUM ION, Putative amidase, dicarbonimidic diamide | 著者 | Peat, T.S, Esquirol, L, Newman, J, Scott, C. | 登録日 | 2017-09-11 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841. PLoS ONE, 13, 2018
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7OT2
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![BU of 7ot2 by Molmil](/molmil-images/mine/7ot2) | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4j | 分子名称: | 3-[[2-(trifluoromethyl)phenyl]methylamino]pyrazine-2-carboxamide, Bifunctional glutamate/proline--tRNA ligase, PROLINE, ... | 著者 | Pang, L, Zitko, J, Strelkov, S.V, Weeks, S.D. | 登録日 | 2021-06-09 | 公開日 | 2021-07-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies. Int J Mol Sci, 22, 2021
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7OPI
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6VFW
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![BU of 6vfw by Molmil](/molmil-images/mine/6vfw) | Crystal structure of human delta protocadherin 10 EC1-EC4 | 分子名称: | CALCIUM ION, Protocadherin-10, alpha-D-mannopyranose, ... | 著者 | Harrison, O.J, Brasch, J, Shapiro, L. | 登録日 | 2020-01-06 | 公開日 | 2020-03-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered delta-Protocadherins. Cell Rep, 30, 2020
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6PAQ
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7OM2
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![BU of 7om2 by Molmil](/molmil-images/mine/7om2) | Thosea asigna virus RdRP domain in complex with Mg+2 | 分子名称: | GLYCEROL, MAGNESIUM ION, RNA-dependent RNA polymerase, ... | 著者 | Ferrero, D.S, Falqui, M, Verdaguer, N. | 登録日 | 2021-05-21 | 公開日 | 2021-07-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Snapshots of a Non-Canonical RdRP in Action. Viruses, 13, 2021
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8D4Z
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![BU of 8d4z by Molmil](/molmil-images/mine/8d4z) | Crystal structure of USP7 in complex with allosteric inhibitor FX1-3763 | 分子名称: | 1-({(7M)-7-[1-(azetidin-3-yl)-6-chloro-1,2,3,4-tetrahydroquinolin-8-yl]thieno[3,2-b]pyridin-2-yl}methyl)pyrrolidine-2,5-dione, GLYCEROL, Ubiquitin carboxyl-terminal hydrolase 7 | 著者 | Bell, J.A. | 登録日 | 2022-06-03 | 公開日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Novel USP7 inhibitors demonstrate potent anti-cancer activity in models of AML, synergy with BCL2 inhibition, and a differentiated mechanism of action To Be Published
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8PML
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![BU of 8pml by Molmil](/molmil-images/mine/8pml) | Structure of Nal1 protein , SPIKE allele from japonica rice, construct 46-458 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein NARROW LEAF 1 | 著者 | Huang, L.Y, Rety, S, Xi, X.G. | 登録日 | 2023-06-29 | 公開日 | 2024-04-17 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | The catalytic triad of rice NARROW LEAF1 involves H234. Nat.Plants, 10, 2024
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6MHF
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![BU of 6mhf by Molmil](/molmil-images/mine/6mhf) | Galphai3 co-crystallized with GIV/Girdin | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Girdin, ... | 著者 | Rees, S.D, Kalogriopoulos, N.A, Ngo, T, Kopcho, N, Ilatovskiy, A, Sun, N, Komives, E, Chang, G, Ghosh, P, Kufareva, I. | 登録日 | 2018-09-17 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc.Natl.Acad.Sci.USA, 116, 2019
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6VGW
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![BU of 6vgw by Molmil](/molmil-images/mine/6vgw) | Crystal structure of VidaL intein (selenomethionine variant) | 分子名称: | GLYCEROL, SULFATE ION, VidaL | 著者 | Burton, A.J, Haugbro, M, Parisi, E, Muir, T.W. | 登録日 | 2020-01-09 | 公開日 | 2020-05-27 | 最終更新日 | 2020-06-17 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Live-cell protein engineering with an ultra-short split intein. Proc.Natl.Acad.Sci.USA, 117, 2020
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6PB9
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6MJY
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6PI5
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![BU of 6pi5 by Molmil](/molmil-images/mine/6pi5) | The evolving story of AtzT, a periplasmic binding protein | 分子名称: | Atrazine periplasmic binding protein, DIMETHYL SULFOXIDE, GUANINE | 著者 | Peat, T.S, Newman, J, Scott, C, Esquirol, L, Dennis, M, Nebl, T. | 登録日 | 2019-06-26 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | The evolving story of AtzT, a periplasmic binding protein. Acta Crystallogr D Struct Biol, 75, 2019
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7OOV
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![BU of 7oov by Molmil](/molmil-images/mine/7oov) | Crystal structure of PIM1 in complex with ARC-1411 | 分子名称: | 1,2-ETHANEDIOL, Inhibitor ARC-1411, SULFATE ION, ... | 著者 | Chaikuad, A, Dixon-Clarke, S.E, Nonga, O.E, Uri, A, Bullock, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-28 | 公開日 | 2021-08-04 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family. Molecules, 26, 2021
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6VH1
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![BU of 6vh1 by Molmil](/molmil-images/mine/6vh1) | 2.30 A resolution structure of MERS 3CL protease in complex with inhibitor 6h | 分子名称: | N~2~-{[(4,4-difluorocyclohexyl)oxy]carbonyl}-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, Orf1a protein | 著者 | Lovell, S, Battaile, K.P, Kashipathy, M.M, Rathnayake, A.D, Zheng, J, Kim, Y, Nguyen, H.N, Chang, K.O, Groutas, W.C. | 登録日 | 2020-01-09 | 公開日 | 2020-08-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Sci Transl Med, 12, 2020
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6B12
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