PDB: 2005 件ウェブページステータス検索Chemie searchBIRD

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6QSN	Crystal structure of Yellow fever virus polymerase NS5A 分子名称: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Boura, E, Dubankova, A. 登録日 2019-02-21 公開日 2019-10-16 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.004 Å) 主引用文献 Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses. Antiviral Res., 169, 2019
5W41	Zika MR766 NLS in complex with Importin alpha subunit-1 分子名称: Importin subunit alpha-1, ZIKA MR766 NLS 著者 Jeffress, S, Smith, K.M, Forwood, J.K. 登録日 2017-06-08 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Zika virus NS5 forms supramolecular nuclear bodies that sequester importin alpha and modulate the host immune and pro-inflammatory response in neuronal cells. ACS Infect Dis, 2019
1MWH	REOVIRUS POLYMERASE LAMBDA3 BOUND TO MRNA CAP ANALOG 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, MANGANESE (II) ION, MINOR CORE PROTEIN LAMBDA 3 著者 Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. 登録日 2002-09-29 公開日 2002-12-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 RNA Synthesis in a Cage-Structural Studies of Reovirus Polymerase lambda3 Cell(Cambridge,Mass.), 111, 2002
2NVT	RNA Polymerase II Elongation Complex in 150 mM Mg+2 with GMPCPP 分子名称: 5'-D(*GP*TP*AP*CP*TP*TP*G)-3', 5'-D(P*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*TP*GP*GP*TP*CP*TP*T)-3', 5'-R(*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... 著者 Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. 登録日 2006-11-13 公開日 2006-12-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Cell(Cambridge,Mass.), 127, 2006
2NVY	RNA Polymerase II form II in 150 mM Mn+2 分子名称: DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 45 kDa polypeptide, ... 著者 Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. 登録日 2006-11-13 公開日 2006-12-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Cell(Cambridge,Mass.), 127, 2006
2NVZ	RNA Polymerase II elongation complex with UTP, updated 11/2006 分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ... 著者 Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D. 登録日 2006-11-14 公開日 2006-12-19 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (4.3 Å) 主引用文献 Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Cell(Cambridge,Mass.), 127, 2006
4JY0	Crystal structure of hcv ns5b polymerase in complex with compound 3 分子名称: (4S,5R)-1-(4-tert-butylbenzoyl)-2-(2-methylpropyl)-4-pyrazin-2-yl-5-(1,3-thiazol-2-yl)-L-proline, Genome polyprotein 著者 Coulombe, R. 登録日 2013-03-28 公開日 2014-04-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Distinguishing drug binding pockets on proteins by complementary biophysical and biological methods. To be Published
2JXF	The solution structure of HCV NS4B(40-69) 分子名称: Genome polyprotein 著者 Montserret, R, Penin, F. 登録日 2007-11-19 公開日 2008-11-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B J.Virol., 83, 2009
2O5D	Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study 分子名称: (2S)-2-({(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}AMINO)-2-(4-FLUOROPHENYL)-N-[(4-NITROPHENYL)SULFONYL]ACETAMIDE, HCV 著者 Yao, N. 登録日 2006-12-05 公開日 2007-02-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study. Bioorg.Med.Chem.Lett., 17, 2007
7F4G	Structure of RPAP2-bound RNA polymerase II 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Chen, X, Qi, Y, Wang, X, Li, J, Zhao, D, Xu, Y. 登録日 2021-06-18 公開日 2021-07-07 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (2.78 Å) 主引用文献 RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex. Cell Rep, 39, 2022
1NG7	The Solution Structure of the Soluble Domain of Poliovirus 3A Protein 分子名称: Genome polyprotein [Core protein P3A] 著者 Strauss, D.M, Glustrom, L.W, Wuttke, D.S. 登録日 2002-12-16 公開日 2003-07-15 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Towards an understanding of the poliovirus replication complex: the solution structure of the soluble domain of the poliovirus 3A protein. J.Mol.Biol., 330, 2003
1DZF	RPB5 from S.cerevisiae 分子名称: DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 著者 Todone, F, Weinzierl, R.O.J, Brick, P, Onesti, S. 登録日 2000-02-25 公開日 2000-06-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of Rpb5, a Universal Eukaryotic RNA Polymerase Subunit and Transcription Factor Interaction Target Proc.Natl.Acad.Sci.USA, 97, 2000
4ES5	Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Bar-headed Gs/Qinghai/15c/2005 (h5n1) with bound m7GTP 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Polymerase basic subunit 2, SULFATE ION 著者 Meng, G, Liu, Y, Zheng, X. 登録日 2012-04-22 公開日 2013-03-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus J.Biol.Chem., 288, 2013
1N38	reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed 分子名称: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 3'-DEOXY-URIDINE 5'-TRIPHOSPHATE, 5'-R(*AP*UP*UP*AP*GP*C)-3', ... 著者 Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. 登録日 2002-10-25 公開日 2002-12-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 RNA Synthesis in a Cage--Structural Studies of Reovirus Polymerase [lambda] 3 Cell(Cambridge,Mass.), 111, 2002
1QJX	HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND WIN68934 分子名称: 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[4-METHYL-2H-TETRAZOL-2-YL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... 著者 Hadfield, A.T, Diana, G.D, Rossmann, M.G. 登録日 1999-07-06 公開日 1999-07-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
1QJU	HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP61209 分子名称: 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2N-METHYL-2H-TETRAZOL-5-YL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... 著者 Hadfield, A.T, Minor, I, Diana, G.D, Rossmann, M.G. 登録日 1999-07-05 公開日 1999-07-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
1QJY	HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP65099 分子名称: 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2-METHYL-4-ISOXAZOLYL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... 著者 Hadfield, A.T, Diana, G.D, Rossmann, M.G. 登録日 1999-07-06 公開日 1999-07-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
1N1H	Initiation complex of polymerase lambda3 from reovirus 分子名称: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 5'-R(*AP*UP*UP*AP*GP*C)-3', ... 著者 Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. 登録日 2002-10-17 公開日 2002-12-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 RNA Synthesis in a Cage--Structural Studies of Reovirus Polymerase [lambda] 3 Cell(Cambridge,Mass.), 111, 2002
1N35	lambda3 elongation complex with four phosphodiester bond formed 分子名称: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 5'-R(*AP*UP*UP*AP*GP*CP*CP*CP*CP*C)-3', 5'-R(P*GP*GP*GP*GP*G)-3', ... 著者 Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C. 登録日 2002-10-25 公開日 2002-12-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 RNA Synthesis in a Cage--Structural Studies of Reovirus Polymerase [lambda] 3 Cell(Cambridge,Mass.), 111, 2002
7K9Y	GsI-IIC RT Template-Switching Complex (twinned) 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*TP*CP*CP*AP*GP*GP*CP*AP*AP*C)-3'), MAGNESIUM ION, ... 著者 Stamos, J.L, Lentzsch, A.M. 登録日 2020-09-29 公開日 2021-08-18 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural basis for template switching by a group II intron-encoded non-LTR-retroelement reverse transcriptase. J.Biol.Chem., 297, 2021
7UIG	Mediator-PIC Early (Mediator A) 分子名称: DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ... 著者 Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. 登録日 2022-03-29 公開日 2023-02-15 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of a transcription pre-initiation complex on a divergent promoter. Mol.Cell, 83, 2023
6NUS	SARS-Coronavirus NSP12 bound to NSP8 co-factor 分子名称: NSP12, NSP8, ZINC ION 著者 Kirchdoerfer, R.N, Ward, A.B. 登録日 2019-02-01 公開日 2019-05-29 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors. Nat Commun, 10, 2019
2WK4	Dimeric structure of D347G D348G mutant of the sapporovirus RNA dependent RNA polymerase 分子名称: GLYCEROL, PROTEASE-POLYMERASE P70 著者 Fullerton, S.W.B, Robel, I, Schuldt, L, Gebhardt, J, Tucker, P.A, Rohayem, J. 登録日 2009-06-05 公開日 2010-09-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Dimeric Structure of D347G D348G Mutant of the Sapporovirus Sapporovirus RNA Dependent RNA Polymerase To be Published
2JDQ	C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5 分子名称: IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC PROTEIN 2 著者 Tarendeau, F, Guilligay, D, Mas, P, Boulo, S, Baudin, F, Ruigrok, R.W.H, Hart, D.J, Cusack, S. 登録日 2007-01-11 公開日 2007-02-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit Nat.Struct.Mol.Biol., 14, 2007
8CQH	Ntaya virus methyltransferase in complex with GTP and SAH 分子名称: GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ... 著者 Boura, E, Krejcova, K. 登録日 2023-03-06 公開日 2024-03-13 最終更新日 2024-09-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase. Structure, 32, 2024

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