8U06
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8U07
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8U0H
| Crystal structure of PTPN2 with a PROTAC | 分子名称: | (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[2-(4-{3-[(3R)-2,6-dioxopiperidin-3-yl]-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl}piperidin-1-yl)acetamido]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid, ACETATE ION, PTPN2, ... | 著者 | Jain, R, Longenecker, K, Qiu, W. | 登録日 | 2023-08-29 | 公開日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex. Commun Chem, 7, 2024
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8JNE
| The cryo-EM structure of the decameric RAD51 ring bound to the nucleosome without the linker DNA binding | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.68 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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8JNF
| The cryo-EM structure of the RAD51 filament bound to the nucleosome | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.91 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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8JND
| The cryo-EM structure of the nonameric RAD51 ring bound to the nucleosome with the linker DNA binding | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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7D5K
| CryoEM structure of cotton cellulose synthase isoform 7 | 分子名称: | Cellulose synthase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | 著者 | Guan, Z.Y, Xue, Y, Yin, P, Zhang, X.L. | 登録日 | 2020-09-26 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into homotrimeric assembly of cellulose synthase CesA7 from Gossypium hirsutum. Plant Biotechnol J, 19, 2021
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7DC3
| Crystal structure of the MyRF ICA domain | 分子名称: | Isoform 2 of Myelin regulatory factor | 著者 | Shi, N, Wu, P, Zhen, X.K, Li, B.W. | 登録日 | 2020-10-23 | 公開日 | 2021-08-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the MyRF ICA domain with its upstream beta-helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage. Int J Biol Sci, 17, 2021
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8V2D
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5K9M
| Crystal Structure of PriB Binary Complex with Product Diphosphate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYROPHOSPHATE 2-, PriB Prenyltransferase | 著者 | Cao, H, Elshahawi, S, Benach, J, Wasserman, S.R, Morisco, L.L, Koss, J.W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2016-06-01 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure and specificity of a permissive bacterial C-prenyltransferase. Nat. Chem. Biol., 13, 2017
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7DPQ
| HIV-1 Protease D30N mutant | 分子名称: | Protease | 著者 | Bihani, S.C, Hosur, M.V. | 登録日 | 2020-12-21 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Molecular basis for reduced cleavage activity and drug resistance in D30N HIV-1 protease. J.Biomol.Struct.Dyn., 2021
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7DOZ
| HIV-1 Protease D30N mutant in complex with Nelfinavir | 分子名称: | 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE, Protease | 著者 | Bihani, S.C, Hosur, M.V. | 登録日 | 2020-12-17 | 公開日 | 2021-10-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Molecular basis for reduced cleavage activity and drug resistance in D30N HIV-1 protease. J.Biomol.Struct.Dyn., 2021
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8UCF
| Thermophilic RNA Ligase from Palaeococcus pacificus K238G | 分子名称: | ATP dependent DNA ligase, GLYCEROL, MAGNESIUM ION | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | 登録日 | 2023-09-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus. Nucleic Acids Res., 52, 2024
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8UCH
| Thermophilic RNA Ligase from Palaeococcus pacificus K92A + ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP dependent DNA ligase, GLYCEROL, ... | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | 登録日 | 2023-09-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus. Nucleic Acids Res., 52, 2024
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8UCE
| Thermophilic RNA Ligase from Palaeococcus pacificus + AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, ATP dependent DNA ligase, GLYCEROL, ... | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | 登録日 | 2023-09-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus. Nucleic Acids Res., 52, 2024
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8UCI
| Thermophilic RNA Ligase from Palaeococcus pacificus K238G + AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, ATP dependent DNA ligase, GLYCEROL, ... | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | 登録日 | 2023-09-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus. Nucleic Acids Res., 52, 2024
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7JL3
| Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ... | 著者 | Kato, K, Ahmad, S, Hur, S. | 登録日 | 2020-07-29 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Mol.Cell, 81, 2021
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8UCG
| Thermophilic RNA Ligase from Palaeococcus pacificus K92A | 分子名称: | ATP dependent DNA ligase, GLYCEROL, MAGNESIUM ION, ... | 著者 | Rousseau, M.D, Hicks, J.L, Oulavallickal, T, Williamson, A, Arcus, V.L, Patrick, M.W. | 登録日 | 2023-09-26 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus. Nucleic Acids Res., 52, 2024
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8VB1
| Crystal structure of HIV-1 protease with GS-9770 | 分子名称: | (2S)-2-{(3M)-4-chloro-3-[1-(difluoromethyl)-1H-1,2,4-triazol-5-yl]phenyl}-2-[(2E,4R)-4-[4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)phenyl]-2-imino-5-oxo-4-(3,3,3-trifluoro-2,2-dimethylpropyl)imidazolidin-1-yl]ethyl [1-(difluoromethyl)cyclopropyl]carbamate, HIV-1 protease | 著者 | Lansdon, E.B. | 登録日 | 2023-12-11 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrob.Agents Chemother., 68, 2024
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6ZJ3
| Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis | 分子名称: | 18S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Matzov, D, Halfon, H, Zimmerman, E, Rozenberg, H, Bashan, A, Gray, M.W, Yonath, A.E, Shalev-Benami, M. | 登録日 | 2020-06-27 | 公開日 | 2020-10-07 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis. Nucleic Acids Res., 48, 2020
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7BJ3
| ScpA from Streptococcus pyogenes, S512A active site mutant | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, C5a peptidase, CALCIUM ION, ... | 著者 | Kagawa, T.F, O'Connell, M.R, Cooney, J.C. | 登録日 | 2021-01-13 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease. Comput Struct Biotechnol J, 19, 2021
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7BJK
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7JL0
| Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | 著者 | Kato, K, Ahmad, S, Hur, S. | 登録日 | 2020-07-29 | 公開日 | 2020-12-09 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Mol.Cell, 81, 2021
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8VC6
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8VC4
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