8UUM
| Prototypic SARS-CoV-2 spike (containing K417) in the open conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, alpha-D-mannopyranose, ... | 著者 | Geng, Q, Liu, B, Li, F. | 登録日 | 2023-11-01 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein. Elife, 12, 2023
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8UUL
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8UUK
| Pendrin in apo | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Wang, L, Hoang, A, Zhou, M. | 登録日 | 2023-11-01 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Mechanism of anion exchange and small-molecule inhibition of pendrin. Nat Commun, 15, 2024
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8UUH
| SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12199 | 分子名称: | 5-[2-(dimethylamino)ethoxy]-2-methyl-N-[(1R)-1-{(3M,5P)-3-(1-methyl-1H-pyrazol-4-yl)-5-[1-(propan-2-yl)-1H-pyrazol-4-yl]phenyl}ethyl]benzamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-01 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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8UUG
| SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12303 | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-01 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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8UTL
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8UTK
| IL-23R minibinder - 23R-B04dslf02IB | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 23R-B04dslf02IB, ... | 著者 | Bera, A.K, Berger, S.A, Kang, A, Baker, D. | 登録日 | 2023-10-31 | 公開日 | 2024-07-10 | 最終更新日 | 2024-08-28 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Preclinical proof of principle for orally delivered Th17 antagonist miniproteins. Cell, 187, 2024
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8UTG
| An RNA G-Quadruplex from the NS5 gene in the West Nile Virus Genome | 分子名称: | AMMONIUM ION, POTASSIUM ION, RNA (5'-R(*UP*AP*UP*GP*GP*AP*AP*GP*AP*GP*GP*CP*GP*GP*UP*UP*GP*GP*UP*AP*U)-3') | 著者 | Terrell, J.R, Le, T.T, Wilson, W.D, Siemer, J.L. | 登録日 | 2023-10-31 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structure of an RNA G-quadruplex from the West Nile virus genome. Nat Commun, 15, 2024
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8UTE
| Structure of SARS-Cov2 3CLPro in complex with Compound 27 | 分子名称: | 1,2-ETHANEDIOL, 3C-like proteinase nsp5, methyl {(2S)-1-[(1S,3aR,6aS)-1-{[(2R,3S)-6,6-difluoro-2-hydroxy-1-(methylamino)-1-oxoheptan-3-yl]carbamoyl}hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-3,3-dimethyl-1-oxobutan-2-yl}carbamate | 著者 | Krishnamurthy, H, Zhuang, N, Qiang, D, Wu, Y, Klein, D.J. | 登録日 | 2023-10-31 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic. J.Med.Chem., 67, 2024
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8UT9
| CryoEM structure of A/Shanghai/1/2013 H7 in complex with polyclonal Fab from mice immunized with H7 stem nanoparticles-28 days post immunization | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Huang, J, Han, J, Ward, A.B. | 登録日 | 2023-10-30 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity, 57, 2024
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8UT8
| CryoEM structure of A/Shanghai/1/2013 H7 in complex with polyclonal Fab from mice immunized with H7 stem nanoparticles-15 days post-immunization | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Huang, J, Han, J, Ward, A.B. | 登録日 | 2023-10-30 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity, 57, 2024
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8UT7
| CryoEM structure of A/Perth/16/2009 H3 in complex with polyclonal Fab from mice immunized with H3 stem nanoparticles-28 days post immunization | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H3D28 pFab HC Fv_polyA, ... | 著者 | Huang, J, Han, J, Ward, A.B. | 登録日 | 2023-10-30 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity, 57, 2024
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8UT6
| CryoEM structure of A/Perth/16/2009 H3 in complex with polyclonal Fab from mice immunized with H3 stem nanoparticles-15 days post immunization | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H3D15 pFab HC Fv_polyA, ... | 著者 | Huang, J, Han, J, Ward, A.B. | 登録日 | 2023-10-30 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity, 57, 2024
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8UT5
| CryoEM structure of A/Michigan/45/2015 H1 in complex with flu HA central stem VH1-18 antibody UCA6_N55T | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ... | 著者 | Huang, J, Han, J, Ward, A.B. | 登録日 | 2023-10-30 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity, 57, 2024
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8UT4
| CryoEM structure of A/Michigan/45/2015 H1 in complex with flu HA central stem VH1-18 antibody 09-1B12 | 分子名称: | 09-1B12 HC Fv, 09-1B12 LC Fv, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Huang, J, Han, J, Ward, A.B. | 登録日 | 2023-10-30 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity, 57, 2024
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8UT3
| CryoEM structure of A/Perth/16/2009 H3 in complex with flu HA central stem VH1-18 antibody UCA6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | 著者 | Huang, J, Han, J, Ward, A.B. | 登録日 | 2023-10-30 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity, 57, 2024
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8USS
| IL17A complexed to Compound 7 | 分子名称: | 4,5-dichloro-N-[(1S)-1-cyclohexyl-2-{[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}-2-oxoethyl]-1H-pyrrole-2-carboxamide, CHLORIDE ION, Interleukin-17A | 著者 | Argiriadi, M.A, Ramos, A.L. | 登録日 | 2023-10-29 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. J.Med.Chem., 67, 2024
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8USR
| IL17A homodimer complexed to Compound 23 | 分子名称: | Interleukin-17A, ~{N}-[(2~{S})-1-[[(1~{S})-1-(8~{a}~{H}-imidazo[1,2-a]pyrimidin-2-yl)ethyl]amino]-1-oxidanylidene-4-phenyl-butan-2-yl]-4,5-bis(chloranyl)-1~{H}-pyrrole-2-carboxamide | 著者 | Argiriadi, M.A, Ramos, A.L. | 登録日 | 2023-10-29 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. J.Med.Chem., 67, 2024
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8US4
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8US3
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8US2
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8US1
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8URW
| Cyanobacterial RNA polymerase elongation complex with NusG and CTP | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, DNA (40-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Qayyum, M.Z, Imashimizu, M, Leanca, M, Vishwakarma, R.K, Bradley Riaz, A, Yuzenkova, Y, Murakami, K.S. | 登録日 | 2023-10-26 | 公開日 | 2023-12-27 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Structure and function of the Si3 insertion integrated into the trigger loop/helix of cyanobacterial RNA polymerase. Proc.Natl.Acad.Sci.USA, 121, 2024
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8URF
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8UR9
| Crystal Structure of the SARS-CoV-2 Main Protease in Complex with Compound 61 | 分子名称: | (5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione, 3C-like proteinase nsp5 | 著者 | Papini, C, Zhang, C.H, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-10-25 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proc.Natl.Acad.Sci.USA, 121, 2024
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