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7ZSC
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BU of 7zsc by Molmil
Crystal structure of the heterodimeric human C-P4H-II with truncated alpha subunit (C-P4H-II delta281)
分子名称: Prolyl 4-hydroxylase subunit alpha-2, Protein disulfide-isomerase, SULFATE ION
著者Lebedev, A, Koski, M.K, Wierenga, R.K, Murthy, A.V, Sulu, R.
登録日2022-05-06
公開日2022-11-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.85 Å)
主引用文献Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H alpha 2 beta 2 tetramer.
J.Biol.Chem., 298, 2022
5YU9
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BU of 5yu9 by Molmil
Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib
分子名称: 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, CHLORIDE ION, Epidermal growth factor receptor
著者Yan, X.E, Yun, C.H.
登録日2017-11-21
公開日2017-12-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation.
Oncotarget, 7, 2016
7A5C
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BU of 7a5c by Molmil
Crystal structure of spin labelled VcSiaP R125A bound to an artificial peptide ligand.
分子名称: GLYCEROL, Sialic acid-binding periplasmic protein SiaP
著者Peter, M.F, Glaenzer, J, Hagelueken, G.
登録日2020-08-21
公開日2020-12-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Triggering Closure of a Sialic Acid TRAP Transporter Substrate Binding Protein through Binding of Natural or Artificial Substrates.
J.Mol.Biol., 433, 2020
4X2E
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BU of 4x2e by Molmil
Clostridium difficile wild type Fic protein
分子名称: Fic family protein putative filamentation induced by cAMP protein
著者Jorgensen, R, Dedic, E.
登録日2014-11-26
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.104 Å)
主引用文献Structure of wild type Clostridium difficile Fic_0569 at 3.1 Angstroms resolution
To Be Published
1O6D
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BU of 1o6d by Molmil
Crystal structure of a hypothetical protein
分子名称: Hypothetical UPF0247 protein TM0844
著者Structural GenomiX
登録日2003-11-03
公開日2003-11-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
6ZOX
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BU of 6zox by Molmil
Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x2 disulphide-bond mutant, G413C, V987C, single Arg S1/S2 cleavage site)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G.
登録日2020-07-08
公開日2020-07-22
最終更新日2021-06-02
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat.Struct.Mol.Biol., 27, 2020
6ZP2
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BU of 6zp2 by Molmil
Structure of SARS-CoV-2 Spike Protein Trimer (K986P, V987P, single Arg S1/S2 cleavage site) in Locked State
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ...
著者Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G.
登録日2020-07-08
公開日2020-07-22
最終更新日2022-03-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献A thermostable, closed SARS-CoV-2 spike protein trimer.
Nat.Struct.Mol.Biol., 27, 2020
1OBC
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BU of 1obc by Molmil
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
分子名称: 2'-AMINO-2'-DEOXYADENOSINE, LEUCINE, LEUCYL-TRNA SYNTHETASE, ...
著者Cusack, S, Yaremchuk, A, Tukalo, M.
登録日2003-01-30
公開日2003-05-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase
Mol.Cell, 11, 2003
8BB8
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BU of 8bb8 by Molmil
Crystal structure of human aldehyde dehydrogenase ALDH3A1 in complex with octanal
分子名称: ACETATE ION, Aldehyde dehydrogenase, dimeric NADP-preferring, ...
著者Schwartz, M, Neiers, F.
登録日2022-10-12
公開日2023-04-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Characterization of human oxidoreductases involved in aldehyde odorant metabolism.
Sci Rep, 13, 2023
7A0V
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BU of 7a0v by Molmil
Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody
分子名称: GLYCEROL, MAGNESIUM ION, Nanobody 13015, ...
著者Paesmans, J, Galicia, C, Martin, E, Versees, W.
登録日2020-08-11
公開日2020-12-30
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations.
Elife, 9, 2020
1ZYK
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BU of 1zyk by Molmil
Anthranilate Phosphoribosyltransferase in complex with PRPP, anthranilate and magnesium
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, ...
著者Marino, M, Deuss, M, Sterner, R, Mayans, O.
登録日2005-06-10
公開日2006-05-23
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
J.Biol.Chem., 281, 2006
8BJT
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BU of 8bjt by Molmil
Structure of human PLK1 in complex with 2-Allyl-1-[6-(1-hydroxy-1-methyl-ethyl)-pyridin-2-yl]-6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one
分子名称: 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, ACETATE ION, Serine/threonine-protein kinase PLK1, ...
著者Musil, D, Liu-Bujalski, L.
登録日2022-11-06
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.188 Å)
主引用文献Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression.
Acs Med.Chem.Lett., 14, 2023
1O69
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BU of 1o69 by Molmil
Crystal structure of a PLP-dependent enzyme
分子名称: (2-AMINO-4-FORMYL-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, BETA-MERCAPTOETHANOL, aminotransferase
著者Structural GenomiX
登録日2003-10-23
公開日2003-11-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
5WHJ
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BU of 5whj by Molmil
Crystal structure of Fab fragment of anti-FcRn antibody DX-2507
分子名称: DX-2507 Fab heavy chain, DX-2507 Fab light chain
著者Edwards, T.E, Fairman, J.W, Nixon, A.E, Kenniston, J.A.
登録日2017-07-17
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
8B8E
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BU of 8b8e by Molmil
Wild-type GH11 from Blastobotrys mokoenaii
分子名称: 1,2-ETHANEDIOL, BmGH11, DI(HYDROXYETHYL)ETHER, ...
著者Coleman, T, Ravn, J.L, Larsbrink, J.
登録日2022-10-04
公開日2023-05-17
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Yeasts Have Evolved Divergent Enzyme Strategies To Deconstruct and Metabolize Xylan.
Microbiol Spectr, 11, 2023
5WJX
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BU of 5wjx by Molmil
Cryo-EM structure of B. subtilis flagellar filaments S17P
分子名称: Flagellin
著者Wang, F, Burrage, A.M, Orlova, A, Kearns, D.B, Egelman, E.H.
登録日2017-07-24
公開日2017-10-25
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (6.7 Å)
主引用文献A structural model of flagellar filament switching across multiple bacterial species.
Nat Commun, 8, 2017
3HOJ
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BU of 3hoj by Molmil
Crystal Structure of a Novel Engineered Retroaldolase: RA-22
分子名称: RETROALDOLASE-22
著者Stoddard, B.L, Doyle, L.A.
登録日2009-06-02
公開日2009-08-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献De Novo Computational Design of Retro-Aldol Enzymes
Science, 319, 2008
5WNT
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BU of 5wnt by Molmil
Crystal Structure of 30S ribosomal subunit from Thermus thermophilus
分子名称: (1R,2S,3S,4R,6R)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-alpha-L-altropyranosyl)-beta-L-arabinofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-allopyranoside, 16S Ribosomal RNA rRNA, MAGNESIUM ION, ...
著者DeMirci, H.
登録日2017-08-01
公開日2018-02-21
最終更新日2020-10-21
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献2'-O-methylation in mRNA disrupts tRNA decoding during translation elongation.
Nat. Struct. Mol. Biol., 25, 2018
1NNQ
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BU of 1nnq by Molmil
rubrerythrin from Pyrococcus furiosus Pfu-1210814
分子名称: Rubrerythrin, ZINC ION
著者Liu, Z.-J, Tempel, W, Schubot, F.D, Shah, A, Arendall III, W.B, Rose, J.P, Richardson, D.C, Richardson, J.S, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG)
登録日2003-01-14
公開日2004-03-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin
Proteins, 57, 2004
8BJU
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BU of 8bju by Molmil
HUMAN WEE1 KINASE IN COMPLEX WITH INHIBITOR 1-[6-(1-Hydroxy-1-methyl-ethyl)-pyridin-2-yl]-2-(2-methoxy-phenyl)-6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one
分子名称: 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one, Wee1-like protein kinase
著者Musil, D, Lan, R.
登録日2022-11-06
公開日2023-05-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression.
Acs Med.Chem.Lett., 14, 2023
5WS4
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BU of 5ws4 by Molmil
Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii
分子名称: 5'-O-[(R)-HYDROXY(THIOPHOSPHONOOXY)PHOSPHORYL]ADENOSINE, Macrolide export ATP-binding/permease protein MacB
著者Murakami, S, Okada, U, Yamashita, E.
登録日2016-12-05
公開日2017-11-15
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii.
Nat Commun, 8, 2017
3HWF
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BU of 3hwf by Molmil
Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with Fe-TrenCam2-hopo
分子名称: CHLORIDE ION, FE (III) ION, GLYCEROL, ...
著者Clifton, M.C.
登録日2009-06-17
公開日2010-06-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Parsing the functional specificity of Siderocalin / Lipocalin 2 / NGAL for siderophores and related small-molecule ligands
To be Published
5WIG
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BU of 5wig by Molmil
Structure of New Delhi Metallo-Beta-lactamase 4 (NDM-4)
分子名称: NDM-4, ZINC ION
著者VanPelt, J, Williams, C, Page, R.C.
登録日2017-07-19
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Clinical Variants of New Delhi Metallo-beta-Lactamase Are Evolving To Overcome Zinc Scarcity.
Acs Infect Dis., 3, 2017
7XYQ
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BU of 7xyq by Molmil
Crystal strucutre of PD-L1 and the computationally designed DBL1_03 protein binder
分子名称: ARGININE, CD274 molecule, DBL1_03
著者Liu, K, Xu, Z, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S.
登録日2022-06-02
公開日2023-04-12
最終更新日2023-05-17
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献De novo design of protein interactions with learned surface fingerprints.
Nature, 617, 2023
8BVH
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BU of 8bvh by Molmil
Cryo-EM structure of the Hfq-Crc-amiE translation repression assembly.
分子名称: Catabolite repression control protein, RNA-binding protein Hfq, amiE
著者Dendooven, T, Luisi, B.F.
登録日2022-12-03
公開日2023-06-07
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Translational regulation by Hfq-Crc assemblies emerges from polymorphic ribonucleoprotein folding.
Embo J., 42, 2023

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