PDB: 230764 件ウェブページステータス検索Chemie searchBIRD

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4Y46	Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors 分子名称: 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea, Mitogen-activated protein kinase 10 著者 Park, H. 登録日 2015-02-10 公開日 2015-05-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors. Acs Med.Chem.Lett., 6, 2015
4YO7	Crystal Structure of an ABC transporter solute binding protein (IPR025997) from Bacillus halodurans C-125 (BH2323, TARGET EFI-511484) with bound myo-inositol 分子名称: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, CHLORIDE ION, MAGNESIUM ION, ... 著者 Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Koss, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2015-03-11 公開日 2015-03-25 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of an ABC transporter solute binding protein (IPR025997) from Bacillus halodurans C-125 (BH2323, TARGET EFI-511484) with bound myo-inositol To be published
8XEJ	Cryo-EM structure of human XKR8-basigin complex in lipid nanodisc 分子名称: 1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Fab heavy chain, Fab light chain, ... 著者 Sakuragi, T.S, Kanai, R.K, Kikkawa, M.K, Toyoshima, C.T, Nagata, S.N. 登録日 2023-12-12 公開日 2024-02-28 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.66 Å) 主引用文献 The role of the C-terminal tail region as a plug to regulate XKR8 lipid scramblase. J.Biol.Chem., 300, 2024
7RXP	Fab1512 in complex with the C-terminal alpha-TSR domain of P. falciparum 分子名称: Circumsporozoite protein, Fab1512 heavy chain, Fab1512 light chain 著者 Pholcharee, T, Oyen, D, Wilson, I.A. 登録日 2021-08-23 公開日 2022-03-16 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.761 Å) 主引用文献 A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. Plos Pathog., 18, 2022
7RXI	Fab234 in complex with the C-terminal alpha-TSR domain of P. falciparum 分子名称: Circumsporozoite protein, Fab234 heavy chain, Fab234 light chain 著者 Pholcharee, T, Oyen, D, Wilson, I.A. 登録日 2021-08-23 公開日 2022-03-16 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. Plos Pathog., 18, 2022
5MRD	Human PDK1-PKCiota Kinase Chimera in Complex with Allosteric Compound PS267 Bound to the PIF-Pocket 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3-phosphoinositide-dependent protein kinase 1, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Arencibia, J.M, Froehner, W, Krupa, M, Pastor-Flores, D, Merker, P, Oellerich, T, Neimanis, S, Schmithals, C, Koeberle, V, Suess, E, Zeuzem, S, Stark, H, Piiper, A, Odadzic, D, Schulze, J.O, Biondi, R.M. 登録日 2016-12-22 公開日 2017-01-18 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem. Biol., 12, 2017
7RXL	Fab1488 in complex with the C-terminal alpha-TSR domain of P. falciparum 分子名称: Circumsporozoite protein, Fab1488 heavy chain, Fab1488 light chain 著者 Pholcharee, T, Oyen, D, Wilson, I.A. 登録日 2021-08-23 公開日 2022-03-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.823 Å) 主引用文献 A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. Plos Pathog., 18, 2022
9B3S	Crystal structure of casein kinase 1 delta 1 with tethered phosphorylated tail 分子名称: Casein kinase I isoform delta 著者 Harold, R.L, Yaitanes, N, Tripathi, S.T, Partch, C.L. 登録日 2024-03-20 公開日 2024-09-25 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1. Proc.Natl.Acad.Sci.USA, 121, 2024
5H0Q	Crystal structure of lipid binding protein Nakanori at 1.5A 分子名称: Lipid binding protein 著者 Makino, A, Abe, M, Ishitsuka, R, Murate, M, Kishimoto, T, Sakai, S, Hullin-Matsuda, F, Shimada, Y, Inaba, T, Miyatake, H, Tanaka, H, Kurahashi, A, Pack, C.G, Kasai, R.S, Kubo, S, Schieber, N.L, Dohmae, N, Tochio, N, Hagiwara, K, Sasaki, Y, Aida, Y, Fujimori, F, Kigawa, T, Nishikori, K, Parton, R.G, Kusumi, A, Sako, Y, Anderluh, G, Yamashita, M, Kobayashi, T, Greimel, P, Kobayashi, T. 登録日 2016-10-06 公開日 2016-10-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.501 Å) 主引用文献 A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C FASEB J., 31, 2017
8S60	Tankyrase 2 in complex with a quinazolin-4-one inhibitor 分子名称: 8-nitro-2-[4-(trifluoromethyl)phenyl]-3H-quinazolin-4-one, GLYCEROL, Poly [ADP-ribose] polymerase tankyrase-2, ... 著者 Bosetti, C, Paakkonen, J, Lehtio, L. 登録日 2024-02-26 公開日 2025-03-12 最終更新日 2025-03-26 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors. Eur.J.Med.Chem., 288, 2025
8J29	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus 分子名称: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR 著者 Ma, Q, Liu, C. 登録日 2023-04-14 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
7SAG	Solution NMR structure of barrettide C 分子名称: Barrettide C 著者 Payne, C.D, Rosengren, K.J. 登録日 2021-09-22 公開日 2022-01-12 最終更新日 2024-10-23 実験手法 SOLUTION NMR 主引用文献 Barrettides: A Peptide Family Specifically Produced by the Deep-Sea Sponge Geodia barretti . J.Nat.Prod., 84, 2021
6XVN	Crystal structure of c-Src SH3 domain without ATCUN motif: monomer 1 分子名称: Proto-oncogene tyrosine-protein kinase Src 著者 Camara-Artigas, A, Plaza-Garrido, M. 登録日 2020-01-22 公開日 2020-04-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
8VFK	Crystal Structure of Delta 109-117 D-Dopachrome Tautomerase (D-DT) 分子名称: CITRATE ANION, D-dopachrome decarboxylase, SODIUM ION 著者 Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-21 公開日 2024-05-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
8VFN	Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 310K 分子名称: D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-21 公開日 2024-05-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
8VFW	Crystal Structure of V113N D-Dopachrome Tautomerase (D-DT) 分子名称: CITRIC ACID, D-dopachrome decarboxylase 著者 Parkins, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-22 公開日 2024-05-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
7YAN	UDP-glucuronosyltransferase2B17 C-terminal domain 分子名称: L(+)-TARTARIC ACID, UDP-glucuronosyltransferase 2B17 著者 Wang, C.Y, Zhang, L. 登録日 2022-06-28 公開日 2023-07-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 UDP-glucuronosyltransferase2B17 C-terminal domain To Be Published
6XVO	Crystal structure of the intertwined dimer of the c-Src SH3 domain without ATCUN motif 分子名称: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL 著者 Camara-Artigas, A, Plaza-Garrido, M. 登録日 2020-01-22 公開日 2020-04-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
8VG5	Crystal Structure of V113N Variant of D-Dopachrome Tautomerase (D-DT) Bound with 4CPPC 分子名称: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, CITRIC ACID, D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-22 公開日 2024-05-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
8VDY	Crystal Structure of Delta 114-117 D-Dopachrome Tautomerase (D-DT) 分子名称: D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-18 公開日 2024-05-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
8VFL	Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 290K 分子名称: D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-21 公開日 2024-05-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 67, 2024
1WGL	Solution Structure of CUE domain in the C-terminal of Human Toll-interacting Protein (Tollip) 分子名称: Toll-interacting protein 著者 Zhao, C, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-05-28 公開日 2004-11-28 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of CUE domain in the C-terminal of Human Toll-interacting Protein (Tollip) To be Published
6XX5	Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin 分子名称: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src 著者 Camara-Artigas, A. 登録日 2020-01-26 公開日 2020-05-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6MYY	Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer, 3 Fabs bound, sharpened map 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 426c DS-SOSIP D3, ... 著者 Borst, A.J, Weidle, C.E, Gray, M.D, Frenz, B, Snijder, J, Joyce, M.G, Georgiev, I.S, Stewart-Jones, G.B.E, Kwong, P.D, McGuire, A.T, DiMaio, F, Stamatatos, L, Pancera, M, Veesler, D. 登録日 2018-11-02 公開日 2018-11-14 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core. Elife, 7, 2018
8PWE	Crystal structure of VDR complex with Novel Des-C-Ring and Aromatic-D-Ring analog 3a 分子名称: (1~{R},3~{S},5~{Z})-4-methylidene-5-[(~{E})-3-[3-(6-methyl-6-oxidanyl-hept-3-ynyl)phenyl]pent-2-enylidene]cyclohexane-1,3-diol, ACETATE ION, Nuclear receptor coactivator 2, ... 著者 Rochel, N. 登録日 2023-07-20 公開日 2024-08-07 最終更新日 2025-03-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Further Studies on the Highly Active Des-C-Ring and Aromatic-D-Ring Analogues of 1 alpha ,25-Dihydroxyvitamin D 3 (Calcitriol): Refinement of the Side Chain. J.Med.Chem., 66, 2023

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