PDB: 1373 件ウェブページステータス検索Chemie searchBIRD

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8JOO	Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate ikarugamycin 分子名称: (1Z,3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-ethyl-2-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.05,16.07,15.08,12]octacosa-1(2),3,13,18-tetraene-20,27,28-trione, Cytochrome P450, FORMIC ACID, ... 著者 Zhang, Y.L, Zhang, L.P, Zhang, C.S. 登録日 2023-06-08 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
8JUA	Multifunctional cytochrome P450 enzyme IkaD from Streptomyces sp. ZJ306, in complex with epoxyikarugamycin 分子名称: (1Z,3E,5S,7R,8R,10R,11R,12S,13R,15S,16R,17S,19Z,26S)-11-ethyl-2-hydroxy-10-methyl-22,27-diaza-14 oxahexacyclo[24.2.1.05,17.07,16.013,15.08,12]nonacosa-1(2),3,19-triene-21,28,29-trione, Cytochrome P450, FORMIC ACID, ... 著者 Zhang, Y.L, Zhang, L.P, Zhang, C.S. 登録日 2023-06-26 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.00001121 Å) 主引用文献 A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
8TDQ	SFX-XFEL structure of CYP121 cocrystallized with substrate cYY 分子名称: (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Nguyen, R.C, Dasgupta, M, Bhowmick, A, Kern, J.F, Liu, A. 登録日 2023-07-04 公開日 2023-11-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121. J.Am.Chem.Soc., 145, 2023
8TDP	Time-resolved SFX-XFEL crystal structure of CYP121 bound with cYY reacted with peracetic acid for 200 milliseconds 分子名称: (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, HYDROGEN PEROXIDE, Mycocyclosin synthase, ... 著者 Nguyen, R.C, Dasgupta, M, Bhowmick, A, Kern, J.F, Liu, A. 登録日 2023-07-04 公開日 2023-11-22 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121. J.Am.Chem.Soc., 145, 2023
8HGB	Crystal structure of the CYP199A4 mutant F182G in complex with 3-hydroxy-4-methoxybenzoic acid 分子名称: 4-methoxy-3-oxidanyl-benzoic acid, Cytochrome P450, GLYCEROL, ... 著者 Jiang, Y, Cong, Z. 登録日 2022-11-14 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Crystal structure of the CYP199A4 mutant F182G in complex with 3-hydroxy-4-methoxybenzoic acid To Be Published
8HGE	Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei in complex with 12-hydroxydodecanoic acid 分子名称: 12-HYDROXYDODECANOIC ACID, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Cong, Z. 登録日 2022-11-14 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei in complex with 12-hydroxydodecanoic acid To Be Published
8HGD	Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei 分子名称: Cytochrome P450, GLYCEROL, METHANOL, ... 著者 Jiang, Y, Cong, Z. 登録日 2022-11-14 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei To Be Published
8JNO	Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate 10-epi-deOH-HSAF 分子名称: (1Z,3E,5S,7S,8R,9S,10S,11R,13R,15R,16S,18Z,25S)-11-ethyl-2,7-dihydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.09,13.08,15.05,16]octacosa-1(2),3,18-triene-20,27,28-trione, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Zhang, Y.L, Zhang, L.P, Zhang, C.S. 登録日 2023-06-06 公開日 2023-11-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
8SPC	Crystal structure of the cytochrome P450 enzyme RufO 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Cytochrome P450, ... 著者 Dratch, B.D, Davis, K.M. 登録日 2023-05-02 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.871 Å) 主引用文献 Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO. Acs Chem.Biol., 18, 2023
8HOO	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Tyr-Nap 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Tyr-Nap, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2022-12-10 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Tyr-Nap To Be Published
8HOR	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4CH3)-Tyr 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Phe(4CH3)-Tyr, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2022-12-10 公開日 2023-12-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
8HOS	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4NO2)-Tyr 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Phe(4NO2)-Tyr, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2022-12-10 公開日 2023-12-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
8HOQ	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4CF3)-Tyr 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Phe(4CF3)-Tyr, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2022-12-10 公開日 2023-12-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
8HOU	Crystal structure of the P450 BM3 heme domain mutant F87A-T268V in complex with Im-N-C4-Phe-Phe 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, Im-N-C4-Phe-Phe, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2022-12-10 公開日 2023-12-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
8HOT	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with NH2-C7-Phe-Phe 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, NH2-C7-Phe-Phe, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2022-12-10 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Crystal structure of the P450 BM3 heme domain mutant F87A in complex with NH2-C7-Phe-Phe To Be Published
8HOP	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Nap-Tyr 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Nap-Tyr, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2022-12-10 公開日 2023-12-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
8HON	Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Tyr-Tyr 分子名称: Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Tyr-Tyr, PROTOPORPHYRIN IX CONTAINING FE 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2022-12-10 公開日 2023-12-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
8JC4	Crystal structure of the P450 BM3 heme domain mutant F87A-T268V in complex with Pyd-Pid-Phe and hydroxylamine 分子名称: 1-pyridin-4-ylpiperidine-4-carboxylic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ... 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2023-05-10 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 C(sp3)-H hydroxylation of Broad-Spectrum Alkanes Catalyzed by an Artificial P450 Peroxygenase Driven by omega-Pyridyl Fatty Acyl Amino Acids. Mol Catal, 550, 2023
8JC3	Crystal structure of the P450 BM3 heme domain mutant F87A-T268V in complex with Pyd-N-C4-Phe and hydroxylamine 分子名称: 4-(pyridin-4-ylamino)butanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, HYDROXYAMINE, ... 著者 Jiang, Y, Dong, S, Feng, Y, Cong, Z. 登録日 2023-05-10 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 C(sp3)-H hydroxylation of Broad-Spectrum Alkanes Catalyzed by an Artificial P450 Peroxygenase Driven by omega-Pyridyl Fatty Acyl Amino Acids. Mol Catal, 550, 2023
8GLZ	Crystal structure of T252E-CYP199A4 in complex with 4-hydroxybenzoic acid. Crystal was initially co-crystallised with 4-methoxybenzoic acid and soaked with 4 mM hydrogen peroxide 分子名称: CHLORIDE ION, Cytochrome P450, P-HYDROXYBENZOIC ACID, ... 著者 Lee, J.H.Z, Bruning, J.B, Bell, S.G. 登録日 2023-03-23 公開日 2023-12-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase. Chemistry, 30, 2024
8GM2	Crystal structure of T252E-CYP199A4 in complex with 4-methoxybenzoic acid soaked with 2 mM hydrogen peroxide 分子名称: 4-METHOXYBENZOIC ACID, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE 著者 Lee, J.H.Z, Bruning, J.B, Bell, S.G. 登録日 2023-03-24 公開日 2023-12-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase. Chemistry, 30, 2024
8U2M	Structure of P450Blt from Micromonospora sp. MW-13 in Complex with Biarylitide 分子名称: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ACETATE ION, Cytochrome P450-SU1, ... 著者 Hansen, M.H, Cryle, M.J. 登録日 2023-09-06 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis Acs Catalysis, 2024
8U3N	Structure of P450Blt from Micromonospora sp. MW-13 分子名称: Cytochrome P450-SU1, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Hansen, M.H, Cryle, M.J, Zhao, Y. 登録日 2023-09-08 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis Acs Catalysis, 2024
8UKZ	Structure of P450Blt from Micromonospora sp. MW-13 with E238A Mutation 分子名称: ACETATE ION, Cytochrome P450-SU1, DI(HYDROXYETHYL)ETHER, ... 著者 Hansen, M.H, Cryle, M.J. 登録日 2023-10-15 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis Acs Catalysis, 2024
8SS0	Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol 分子名称: 3beta-hydroxy-10alpha,13alpha-lanosta-8,24-dien-30-al, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Hargrove, T.Y, Wawrzak, Z, Guengerich, F.P, Lepesheva, G.I. 登録日 2023-05-08 公開日 2024-01-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14 alpha-Demethylation. Angew.Chem.Int.Ed.Engl., 63, 2024

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