PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

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2IF5	Structure of the POZ domain of human LRF, a master regulator of oncogenesis 分子名称: PRASEODYMIUM ION, Zinc finger and BTB domain-containing protein 7A 著者 Schubot, F.D, Waugh, D.S, Tropea, J. 登録日 2006-09-20 公開日 2006-11-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the POZ domain of human LRF, a master regulator of oncogenesis. Biochem.Biophys.Res.Commun., 351, 2006
7NOW	Complex of Nucleoporin-98 and nanobody MS98-27 solved at 1.85A resolution 分子名称: Anti-Nup98 nanobody MS98-27, Nuclear pore complex protein Nup98, SODIUM ION, ... 著者 Sola-Colom, M, Trakhanov, S, Goerlich, D. 登録日 2021-02-26 公開日 2021-04-07 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A checkpoint function for Nup98 in nuclear pore formation suggested by novel inhibitory nanobodies. Embo J., 2024
1PB1	A four location model to explain the stereospecificity of proteins. 分子名称: GLYCEROL, ISOCITRIC ACID, Isocitrate dehydrogenase [NADP], ... 著者 Mesecar, A.D, Koshland Jr, D.E. 登録日 2003-05-14 公開日 2003-06-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Biology: A New Model for Protein Stereospecificity. Nature, 403, 2000
1WRN	Metal Ion dependency of the antiterminator protein, HutP, for binding to the terminator region of hut mRNA- A structural basis 分子名称: DI(HYDROXYETHYL)ETHER, HISTIDINE, Hut operon positive regulatory protein, ... 著者 Kumarevel, T, Mizuno, H, Kumar, P.K.R. 登録日 2004-10-25 公開日 2005-08-30 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterization of the metal ion binding site in the anti-terminator protein, HutP, of Bacillus subtilis Nucleic Acids Res., 33, 2005
1PB3	Sites of binding and orientation in a four location model for protein stereospecificity. 分子名称: GLYCEROL, Isocitrate dehydrogenase [NADP], SULFATE ION 著者 Mesecar, A.D, Koshland Jr, D.E. 登録日 2003-05-14 公開日 2003-06-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Sites of Binding and Orientation in a Four-Location Model for Protein Stereospecificity. IUBMB Life, 49, 2000
2IKQ	Crystal structure of mouse Sts-1 PGM domain in complex with phosphate 分子名称: PHOSPHATE ION, Suppressor of T-cell receptor signaling 1 著者 Chen, Y, Nassar, N. 登録日 2006-10-02 公開日 2007-08-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.609 Å) 主引用文献 A Phosphatase Activity of Sts-1 Contributes to the Suppression of TCR Signaling Mol.Cell, 27, 2007
2ICT	Crystal structure of the bacterial antitoxin HigA from Escherichia coli at pH 8.5. Northeast Structural Genomics TARGET ER390. 分子名称: antitoxin higa 著者 Arbing, M.A, Abashidze, M, Hurley, J.M, Zhao, L, Janjua, H, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Inouye, M, Woychik, N.A, Montelione, G.T, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2006-09-13 公開日 2006-09-26 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems. Structure, 18, 2010
8UC6	Calpain-7:IST1 Complex 分子名称: Calpain-7, IST1 homolog 著者 Paine, E, Whitby, F.G, Hill, C.P, Sunquist, W.I. 登録日 2023-09-25 公開日 2023-10-25 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission. Elife, 12, 2023
2MDR	Solution structure of the third double-stranded RNA-binding domain (dsRBD3) of human adenosine-deaminase ADAR1 分子名称: Double-stranded RNA-specific adenosine deaminase 著者 Barraud, P, Banerjee, S, Mohamed, W.I, Jantsch, M.F, Allain, F.H. 登録日 2013-09-17 公開日 2014-04-30 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1. Proc.Natl.Acad.Sci.USA, 111, 2014
8U0T	PRD-0038 RBD bound to Rhinolophus alcyone ACE2 (local refinement) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, PRD-0038, ... 著者 Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-08-29 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus. Cell Host Microbe, 31, 2023
8U29	Prefusion structure of the PRD-0038 spike glycoprotein ectodomain trimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PRD-0038 Spike glycoprotein, ... 著者 Lee, J, Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-09-05 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus. Cell Host Microbe, 31, 2023
4LYP	Crystal Structure of Glycoside Hydrolase Family 5 Mannosidase from Rhizomucor miehei 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Exo-beta-1,4-mannosidase, GUANIDINE 著者 Jiang, Z.Q, Zhou, P, Yang, S.Q, Liu, Y, Yan, Q.J. 登録日 2013-07-31 公開日 2014-08-06 最終更新日 2014-11-26 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Structural insights into the substrate specificity and transglycosylation activity of a fungal glycoside hydrolase family 5 beta-mannosidase. Acta Crystallogr.,Sect.D, 70, 2014
2MVO	Solution structure of the lantibiotic self-resistance lipoprotein MlbQ from Microbispora ATCC PTA-5024 分子名称: Putative lipoprotein 著者 Pozzi, R, Schwartz, P, Linke, D, Kulik, A, Nega, M, Wohlleben, W, Stegmann, E, Coles, M. 登録日 2014-10-09 公開日 2015-07-15 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Distinct mechanisms contribute to immunity in the lantibiotic NAI-107 producer strain Microbispora ATCC PTA-5024. Environ Microbiol, 18, 2016
8U0Q	Co-crystal structure of optimized analog TDI-13537 provided new insights into the potency determinants of the sulfonamide inhibitor series 分子名称: Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Dementiev, A.A, Michino, M, Vendome, J, Ginn, J, Bryk, R, Olland, A. 登録日 2023-08-29 公開日 2024-01-03 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors. Acs Bio Med Chem Au, 3, 2023
3RUU	FXR with SRC1 and GSK237 分子名称: 6-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1H-indole-3-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... 著者 Williams, S.P, Madauss, K.P. 登録日 2011-05-05 公開日 2011-09-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. Bioorg.Med.Chem.Lett., 21, 2011
1OSJ	STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE 分子名称: 3-ISOPROPYLMALATE DEHYDROGENASE 著者 Qu, C, Akanuma, S, Moriyama, H, Tanaka, N, Oshima, T. 登録日 1996-10-22 公開日 1997-01-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 A mutation at the interface between domains causes rearrangement of domains in 3-isopropylmalate dehydrogenase. Protein Eng., 10, 1997
1XGV	Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix 分子名称: Isocitrate dehydrogenase 著者 Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N.-K, Ladenstein, R. 登録日 2004-09-17 公開日 2005-09-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability J.Mol.Biol., 345, 2005
1OSI	STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE 分子名称: 3-ISOPROPYLMALATE DEHYDROGENASE 著者 Qu, C, Akanuma, S, Moriyama, H, Tanaka, N, Oshima, T. 登録日 1996-10-22 公開日 1997-01-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A mutation at the interface between domains causes rearrangement of domains in 3-isopropylmalate dehydrogenase. Protein Eng., 10, 1997
2N3G	Solution structure of DRB4 dsRBD1 (viz. DRB4(1-72)) 分子名称: Double-stranded RNA-binding protein 4 著者 Deshmukh, M, Chiliveri, S. 登録日 2015-05-29 公開日 2016-09-07 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 DRB4 dsRBD1 drives dsRNA recognition in Arabidopsis thaliana tasi/siRNA pathway. Nucleic Acids Res., 45, 2017
3RUT	FXR with SRC1 and GSK359 分子名称: 6-(4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)-1-benzothiophene-3-carboxylic acid, Bile acid receptor, Nuclear receptor coactivator 1, ... 著者 Williams, S.P, Madauss, K.P. 登録日 2011-05-05 公開日 2011-09-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene. Bioorg.Med.Chem.Lett., 21, 2011
7N8L	PptT PAP(CoA) 9016 complex 分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ... 著者 Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2021-06-15 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. J.Med.Chem., 65, 2022
7N8E	PptT PAP(CoA) 9056 complex 分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ... 著者 Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2021-06-14 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. J.Med.Chem., 65, 2022
7N8M	PptT PAP(CoA) 8978B complex 分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ... 著者 Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2021-06-15 公開日 2022-02-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. J.Med.Chem., 65, 2022
7NQM	Mycobacterium tuberculosis Cytochrome P450 CYP121 in complex with lead compound 10 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(2-pyrimidin-4-ylethyl)-1~{H}-indole, CHLORIDE ION, ... 著者 Selvam, I.R. 登録日 2021-03-01 公開日 2022-02-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen). Eur.J.Med.Chem., 230, 2022
7NQO	Mycobacterium tuberculosis Cytochrome P450 CYP121 in complex with lead compound 21 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[4-[2-(5-bromanyl-1~{H}-indol-3-yl)ethyl]pyrimidin-2-yl]morpholine, CHLORIDE ION, ... 著者 Selvam, I.R. 登録日 2021-03-01 公開日 2022-02-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen). Eur.J.Med.Chem., 230, 2022

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