8E0V
| DAHP (3-deoxy-D-arabinoheptulosonate-7-phosphate) Synthase complexed with Mn(II), PEP, and Pi in unbound:(bound)2:other Conformations | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, PHOSPHOENOLPYRUVATE, ... | 著者 | Berti, P.J, Junop, M.S, Grainger, R. | 登録日 | 2022-08-09 | 公開日 | 2022-10-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation. Biochemistry, 61, 2022
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2NXI
| Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase. | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHATE ION, PHOSPHOENOLPYRUVATE | 著者 | Kona, F, Xu, X, Martin, P, Kuzmic, P, Gatti, D.L. | 登録日 | 2006-11-17 | 公開日 | 2007-07-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and mechanistic changes along an engineered path from metallo to nonmetallo 3-deoxy-D-manno-octulosonate 8-phosphate synthases Biochemistry, 46, 2007
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1VS1
| Crystal structure of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from Aeropyrum pernix in complex with Mn2+ and PEP | 分子名称: | 3-deoxy-7-phosphoheptulonate synthase, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE | 著者 | Shumilin, I.A, Zhou, L, Wu, J, Woodard, R.W, Bauerle, R, Kretsinger, R.H. | 登録日 | 2006-03-09 | 公開日 | 2006-05-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) from Aeropyrum pernix in complex with Mn2+ and PEP TO BE PUBLISHED
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5DCD
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4UMC
| Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water | 分子名称: | L-PHOSPHOLACTATE, MANGANESE (II) ION, PHOSPHATE ION, ... | 著者 | Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J. | 登録日 | 2014-05-16 | 公開日 | 2014-10-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water. Bioorg.Chem., 57, 2014
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5D09
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3PG9
| Thermotoga maritima DAH7P synthase in complex with inhibitor | 分子名称: | AZIDE ION, CHLORIDE ION, NITRATE ION, ... | 著者 | Cross, P.J, Dobson, R.C.J, Patchett, M.L, Parker, E.J. | 登録日 | 2010-10-31 | 公開日 | 2011-01-26 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis J.Biol.Chem., 286, 2011
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1PHW
| Crystal structure of KDO8P synthase in its binary complex with substrate analog 1-deoxy-A5P | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE | 著者 | Vainer, R, Belakhov, V, Rabkin, E, Baasov, T, Adir, N. | 登録日 | 2003-05-29 | 公開日 | 2004-07-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Crystal structures of Escherichia coli KDO8P synthase complexes reveal the source of catalytic irreversibility. J.Mol.Biol., 351, 2005
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4IXX
| Crystal structure of S213G variant DAH7PS without Tyr bound from Neisseria meningitidis | 分子名称: | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, MANGANESE (II) ION, SULFATE ION | 著者 | Cross, P.J, Pietersma, A.L, Allison, T.M, Wilson-Coutts, S.M, Cochrane, F.C, Parker, E.J. | 登録日 | 2013-01-28 | 公開日 | 2013-12-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine. Protein Sci., 22, 2013
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1X8F
| Crystal Structure Of apo-Kdo8P Synthase | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase | 著者 | Vainer, R, Belakhov, V, Rabkin, E, Baasov, T, Adir, N. | 登録日 | 2004-08-18 | 公開日 | 2005-07-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structures of Escherichia coli KDO8P Synthase Complexes Reveal the Source of Catalytic Irreversibility J.Mol.Biol., 351, 2005
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1G7V
| CRYSTAL STRUCTURES OF KDO8P SYNTHASE IN ITS BINARY COMPLEXES WITH THE MECHANISM-BASED INHIBITOR | 分子名称: | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATE ALDOLASE, {[(2,2-DIHYDROXY-ETHYL)-(2,3,4,5-TETRAHYDROXY-6-PHOSPHONOOXY-HEXYL)-AMINO]-METHYL}-PHOSPHONIC ACID | 著者 | Asojo, O.A, Friedman, J.M, Belakhov, V, Shoham, Y, Adir, N, Baasov, T. | 登録日 | 2000-11-14 | 公開日 | 2001-05-16 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor. Biochemistry, 40, 2001
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4Z1B
| Structure of H204A mutant KDO8PS from H.pylori | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase | 著者 | Lee, B.J, Cho, S, Im, H, Yoon, H.J. | 登録日 | 2015-03-27 | 公開日 | 2016-03-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS). Eur.J.Med.Chem., 108, 2016
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8E0Z
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1D9E
| STRUCTURE OF E. COLI KDO8P SYNTHASE | 分子名称: | 3-DEOXY-D-MANNO-OCTULOSONATE 8-PHOSPHATE SYNTHASE, SULFATE ION | 著者 | Radaev, S, Dastidar, P, Patel, M, Woodard, R.W, Gatti, D.L. | 登録日 | 1999-10-27 | 公開日 | 2000-05-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure and mechanism of 3-deoxy-D-manno-octulosonate 8-phosphate synthase. J.Biol.Chem., 275, 2000
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8E0U
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5CZS
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6U8J
| Crystal structure of 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase/phospho-2-dehydro-3-deoxyheptonate aldolase (Aro3) from Candida auris | 分子名称: | Phospho-2-dehydro-3-deoxyheptonate aldolase, UNKNOWN ATOM OR ION | 著者 | Michalska, K, Evdokimova, E, Semper, C, Di Leo, R, Stogios, P.J, Savchenko, A, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-09-05 | 公開日 | 2019-09-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.492 Å) | 主引用文献 | Crystal structure of 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase/phospho-2-dehydro-3-deoxyheptonate aldolase (Aro3) from
Candida auris To Be Published
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5CZ0
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7RUE
| DAHP synthase complexed with trifluoropyruvate semicarbazone | 分子名称: | (2E)-2-(2-carbamoylhydrazinylidene)-3,3,3-trifluoropropanoic acid, MANGANESE (II) ION, Phospho-2-dehydro-3-deoxyheptonate aldolase, ... | 著者 | Heimhalt, M, Mukherjee, P, Grainger, R, Szabla, R, Brown, C, Turner, R, Junop, M.S, Berti, P.J. | 登録日 | 2021-08-16 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | An Inhibitor-in-Pieces Approach to DAHP Synthase Inhibition: Potent Enzyme and Bacterial Growth Inhibition. Acs Infect Dis., 7, 2021
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6AGL
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6MDY
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1QR7
| CRYSTAL STRUCTURE OF PHENYLALANINE-REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE FROM ESCHERICHIA COLI COMPLEXED WITH PB2+ AND PEP | 分子名称: | LEAD (II) ION, PHENYLALANINE-REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE, PHOSPHOENOLPYRUVATE, ... | 著者 | Shumilin, I.A, Kretsinger, R.H, Bauerle, R.H. | 登録日 | 1999-06-18 | 公開日 | 1999-08-31 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of phenylalanine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli. Structure Fold.Des., 7, 1999
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1Q3N
| Crystal structure of KDO8P synthase in its binary complex with substrate PEP | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHOENOLPYRUVATE | 著者 | Vainer, R, Belakhov, V, Rabkin, E, Baasov, T, Adir, N. | 登録日 | 2003-07-31 | 公開日 | 2004-10-12 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structures of Escherichia coli KDO8P synthase complexes reveal the source of catalytic irreversibility. J.Mol.Biol., 351, 2005
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1OFQ
| CRYSTAL STRUCTURE OF THE TYROSINE-REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH MANGANESE(II) | 分子名称: | MANGANESE (II) ION, PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE | 著者 | Koenig, V, Pfeil, A, Heinrich, G, Braus, G.H, Schneider, T.R. | 登録日 | 2003-04-17 | 公開日 | 2004-04-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Substrate and Metal Complexes of 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase from Saccharomyces Cerevisiae Provide New Insights Into the Catalytic Mechanism J.Mol.Biol., 337, 2004
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3QQ1
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