PDB: 16941 件ウェブページステータス検索Chemie searchBIRD

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4O0H	Crystal structure of human L-asparaginase protein with covalently linked substrate L-asparagine 分子名称: BETA-L-ASPARTIC ACID, Isoaspartyl peptidase/L-asparaginase, SODIUM ION 著者 Nomme, J, Lavie, A. 登録日 2013-12-13 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis. J.Mol.Biol., 426, 2014
4O0F	Crystal structure of the human L-asparaginase protein T219A mutant 分子名称: GLYCINE, Isoaspartyl peptidase/L-asparaginase, SODIUM ION 著者 Nomme, J, Lavie, A. 登録日 2013-12-13 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis. J.Mol.Biol., 426, 2014
4PCI	Crystal Structure of the first bromodomain of BRD4 in complex with B16 分子名称: (4S)-1-methyl-4-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 著者 Dong, J, Caflisch, A. 登録日 2014-04-15 公開日 2014-05-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking. Bioorg.Med.Chem.Lett., 24, 2014
5ADI	Structure of human nNOS R354A G357D mutant heme domain in complex with 7-(((5-((Methylamino)methyl)pyridin-3-yl)oxy)methyl)quinolin-2- amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[[5-[(methylideneamino)methyl]pyridin-3-yl]oxymethyl]quinolin-2-amine, NITRIC OXIDE SYNTHASE, ... 著者 Li, H, Poulos, T.L. 登録日 2015-08-20 公開日 2015-10-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
5EN4	Complex of 17-beta-hydroxysteroid dehydrogenase type 14 with inhibitor. 分子名称: 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... 著者 Bertoletti, N, Braun, F, Marchais-Oberwinkler, S, Heine, A, Klebe, G. 登録日 2015-11-09 公開日 2016-11-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J. Med. Chem., 59, 2016
2K7J	Human Acylphosphatase(AcPh) surface charge-optimized 分子名称: Acylphosphatase-1 著者 Gribenko, A.V, Patel, M.M, Liu, J, McCallum, S.A, Wang, C, Makhatadze, G.I. 登録日 2008-08-12 公開日 2009-02-17 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Rational stabilization of enzymes by computational redesign of surface charge-charge interactions Proc.Natl.Acad.Sci.USA, 106, 2009
5ADG	Structure of human nNOS R354A G357D mutant heme domain in complex with 7-((4-Chloro-3-((methylamino)methyl)phenoxy)methyl)quinolin-2- amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[[4-chloranyl-3-(methylaminomethyl)phenoxy]methyl]quinolin-2-amine, GLYCEROL, ... 著者 Li, H, Poulos, T.L. 登録日 2015-08-20 公開日 2015-10-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.982 Å) 主引用文献 Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
5VBQ	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRDT IN COMPLEX WITH BI2536 分子名称: 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Bromodomain testis-specific protein, ... 著者 EMBER, S.W, ZHU, J.-Y, SCHONBRUNN, E. 登録日 2017-03-30 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 2021
2JX3	NMR solution structure of the N-terminal domain of DEK 分子名称: Protein DEK 著者 Matsuo, H, Devany, M. 登録日 2007-11-02 公開日 2008-02-12 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution NMR structure of the N-terminal domain of the human DEK protein Protein Sci., 17, 2008
5ADF	Structure of human nNOS R354A G357D mutant heme domain in complex with 7-(((3-((Dimethylamino)methyl)phenyl)amino)methyl)quinolin-2- amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[[[3-[(dimethylamino)methyl]phenyl]amino]methyl]quinolin-2-amine, NITRIC OXIDE SYNTHASE, ... 著者 Li, H, Poulos, T.L. 登録日 2015-08-20 公開日 2015-10-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.966 Å) 主引用文献 Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
5A86	Structure of pregnane X receptor in complex with a Sphingosine 1- Phosphate Receptor 1 Antagonist 分子名称: 4-chloro-N-[(1R)-1-[1-ethyl-6-(trifluoromethyl)benzimidazol-2-yl]ethyl]benzenesulfonamide, NUCLEAR RECEPTOR COACTIVATOR 1, NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 著者 Xue, Y, Oster, L. 登録日 2015-07-13 公開日 2015-10-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity. J.Med.Chem., 58, 2015
2V2W	T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT 分子名称: BETA-2 MICROGLOBULIN, HIV P17, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ... 著者 Lee, J.K, Stewart-Jones, G, Dong, T, Harlos, K, Di Gleria, K, Dorrell, L, Douek, D.C, Van Der Merwe, P.A, Jones, E.Y, Mcmichael, A.J. 登録日 2007-06-07 公開日 2007-11-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 T Cell Cross-Reactivity and Conformational Changes During Tcr Engagement. J.Exp.Med., 200, 2004
2V2X	T cell cross-reactivity and conformational changes during TCR engagement. 分子名称: BETA-2 MICROGLOBULIN, HIV P17, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ... 著者 Lee, J.K, Stewart-Jones, G, Dong, T, harlos, K, Di Gleria, K, Dorrell, L, Douek, D.C, van der Merwe, P.A, Jones, E.Y, McMichael, A.J. 登録日 2007-06-07 公開日 2007-11-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 T Cell Cross-Reactivity and Conformational Changes During Tcr Engagement. J.Exp.Med., 200, 2004
2RBE	The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors 分子名称: (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Zhang, J, Jordan, S.R, Li, V. 登録日 2007-09-18 公開日 2008-01-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
2UWE	Large CDR3a loop alteration as a function of MHC mutation 分子名称: AHIII TCR ALPHA CHAIN, AHIII TCR BETA CHAIN, BETA-2-MICROGLOBULIN, ... 著者 Miller, P.J, Pazy, Y, Conti, B, Riddle, D, Biddison, W.E, Appella, E, Collins, E.J. 登録日 2007-03-20 公開日 2007-09-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Single Mhc Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding. J.Mol.Biol., 373, 2007
2K7K	Human Acylphosphatase (AcPh) common type 分子名称: Acylphosphatase-1 著者 Gribenko, A.V, Patel, M.M, Liu, J, McCallum, S.A, Wang, C, Makhatadze, G.I. 登録日 2008-08-13 公開日 2009-02-17 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Rational stabilization of enzymes by computational redesign of surface charge-charge interactions Proc.Natl.Acad.Sci.USA, 106, 2009
2V8C	Mouse Profilin IIa in complex with the proline-rich domain of VASP 分子名称: GLYCEROL, ISOPROPYL ALCOHOL, PROFILIN-2, ... 著者 Kursula, P, Downer, J, Witke, W, Wilmanns, M. 登録日 2007-08-06 公開日 2007-12-18 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 High-Resolution Structural Analysis of Mammalian Profilin 2A Complex Formation with Two Physiological Ligands: The Formin Homology 1 Domain of Mdia1 and the Proline-Rich Domain of Vasp. J.Mol.Biol., 375, 2008
2O36	Crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site 分子名称: Thimet oligopeptidase, ZINC ION 著者 Rodgers, D.W, Lim, E.J. 登録日 2006-11-30 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. J.Biol.Chem., 282, 2007
2DW4	Crystal structure of human LSD1 at 2.3 A resolution 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1 著者 Sengoku, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-02 公開日 2007-09-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A Biochem.Biophys.Res.Commun., 366, 2008
2MB0	Solution structure of hnRNP G RRM in complex with the RNA 5'-AUCAAA-3' 分子名称: RNA-binding motif protein, X chromosome, RNA_(5'-R(*AP*UP*CP*AP*AP*A)-3') 著者 Moursy, A, Allain, F.H.-T, Clery, A. 登録日 2013-07-22 公開日 2014-04-09 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation. Nucleic Acids Res., 42, 2014
2EJR	LSD1-tranylcypromine complex 分子名称: Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[7,8-DIMETHYL-2,4-DIOXO-5-(3-PHENYLPROPANOYL)-1,3,4,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPHATE 著者 Sengoku, T, Mimasu, S, Umehara, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-03-20 公開日 2008-01-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A Biochem.Biophys.Res.Commun., 366, 2008
6YQF	Crystal structure of the SYCE2-TEX12 delta-Ctip complex in a 4:4 assembly 分子名称: Synaptonemal complex central element protein 2, Testis-expressed protein 12 著者 Dunce, J.M, Davies, O.R. 登録日 2020-04-16 公開日 2021-04-28 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.33 Å) 主引用文献 Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12. Nat.Struct.Mol.Biol., 28, 2021
5OR8	Crystal Structure of BAZ2A bromodomain in complex with 1,3-dimethyl-benzimidazolone compound 1 分子名称: Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-[(4-fluorophenyl)methyl]-1,3,6-trimethyl-2-oxidanylidene-benzimidazole-5-sulfonamide 著者 Lolli, G, Dalle Vedove, A, Marchand, J.-R, Caflisch, A. 登録日 2017-08-15 公開日 2017-09-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking. J Chem Inf Model, 57, 2017
3SG3	Crystal Structure of GCaMP3-D380Y 分子名称: CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... 著者 Schreiter, E.R, Akerboom, J, Looger, L.L. 登録日 2011-06-14 公開日 2012-06-20 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Optimization of a GCaMP calcium indicator for neural activity imaging. J.Neurosci., 32, 2012
3SG2	Crystal Structure of GCaMP2-T116V,D381Y 分子名称: CALCIUM ION, Myosin light chain kinase, Green fluorescent protein, ... 著者 Schreiter, E.R, Akerboom, J, Looger, L.L. 登録日 2011-06-14 公開日 2012-06-20 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Optimization of a GCaMP calcium indicator for neural activity imaging. J.Neurosci., 32, 2012

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