5W51
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6UQ1
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![BU of 6uq1 by Molmil](/molmil-images/mine/6uq1) | RNA polymerase II elongation complex with 5-guanidinohydantoin lesion in state 6 | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | 著者 | Oh, J, Wang, D. | 登録日 | 2019-10-18 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions. Proc.Natl.Acad.Sci.USA, 117, 2020
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5W4U
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4JVQ
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![BU of 4jvq by Molmil](/molmil-images/mine/4jvq) | Crystal structure of hcv ns5b polymerase in complex with compound 9 | 分子名称: | 5-{4-[(4-methoxybenzoyl)amino]phenoxy}-2-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}benzoic acid, GLYCEROL, Genome polyprotein, ... | 著者 | Coulombe, R. | 登録日 | 2013-03-26 | 公開日 | 2014-02-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Enantiomeric Atropisomers Inhibit HCV Polymerase and/or HIV Matrix: Characterizing Hindered Bond Rotations and Target Selectivity. J.Med.Chem., 57, 2014
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4JU1
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![BU of 4ju1 by Molmil](/molmil-images/mine/4ju1) | Crystal structure of hcv ns5b polymerase in complex with compound 6 | 分子名称: | 6-[3-([1,3]oxazolo[4,5-b]pyridin-2-yl)-2-(trifluoromethyl)phenoxy]-1-(2,4,6-trifluorobenzyl)quinazolin-4(1H)-one, GLYCEROL, Genome polyprotein, ... | 著者 | Coulombe, R. | 登録日 | 2013-03-24 | 公開日 | 2013-07-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
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3HOV
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![BU of 3hov by Molmil](/molmil-images/mine/3hov) | Complete RNA polymerase II elongation complex II | 分子名称: | 5'-D(*AP*GP*CP*TP*CP*AP*A*GP*TP*AP*GP*TP*TP*AP*TP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*T*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*CP*A)-3', ... | 著者 | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | 登録日 | 2009-06-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
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3HOW
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![BU of 3how by Molmil](/molmil-images/mine/3how) | Complete RNA polymerase II elongation complex III with a T-U mismatch and a frayed RNA 3'-uridine | 分子名称: | 5'-D(*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*C*AP*AP*GP*TP*AP*GP*TP*TP*AP*TP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*U*CP*AP*AP*CP*CP*AP*GP*GP*CP*UP*U)-3', ... | 著者 | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | 登録日 | 2009-06-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
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3I4M
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![BU of 3i4m by Molmil](/molmil-images/mine/3i4m) | 8-oxoguanine containing RNA polymerase II elongation complex D | 分子名称: | DNA (5'-D(*AP*G*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*(8OG)P*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Damsma, G.E, Cramer, P. | 登録日 | 2009-07-02 | 公開日 | 2009-09-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Molecular basis of transcriptional mutagenesis at 8-oxoguanine J.Biol.Chem., 284, 2009
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7Z1L
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![BU of 7z1l by Molmil](/molmil-images/mine/7z1l) | Structure of yeast RNA Polymerase III Pre-Termination Complex (PTC) | 分子名称: | (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | 著者 | Girbig, M, Mueller, C.W. | 登録日 | 2022-02-24 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals. Cell Rep, 40, 2022
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7Z1N
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![BU of 7z1n by Molmil](/molmil-images/mine/7z1n) | Structure of yeast RNA Polymerase III Delta C53-C37-C11 | 分子名称: | CHAPSO, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC2, ... | 著者 | Girbig, M, Mueller, C.W. | 登録日 | 2022-02-24 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals. Cell Rep, 40, 2022
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7Z1O
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![BU of 7z1o by Molmil](/molmil-images/mine/7z1o) | Structure of yeast RNA Polymerase III PTC + NTPs | 分子名称: | CHAPSO, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | 著者 | Girbig, M, Mueller, C.W. | 登録日 | 2022-02-24 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals. Cell Rep, 40, 2022
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7Z1M
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![BU of 7z1m by Molmil](/molmil-images/mine/7z1m) | Structure of yeast RNA Polymerase III Elongation Complex (EC) | 分子名称: | (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | 著者 | Girbig, M, Mueller, C.W. | 登録日 | 2022-02-24 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals. Cell Rep, 40, 2022
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3HOY
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![BU of 3hoy by Molmil](/molmil-images/mine/3hoy) | Complete RNA polymerase II elongation complex VI | 分子名称: | 5'-D(*CP*CP*AP*AP*GP*CP*TP*CP*AP*AP*G*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*TP*AP*CP*TP*AP*GP*TP*AP*CP*TP*GP*CP*C)-3', 5'-D(*CP*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*AP*GP*TP*AP*AP*AP*CP*TP*AP*GP*TP*AP*TP*T*GP*AP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP*T)-3', 5'-R(*UP*AP*UP*AP*UP*GP*CP*A*UP*AP*AP*AP*GP*AP*CP*CP*AP*GP*GP*A)-3', ... | 著者 | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | 登録日 | 2009-06-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
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3HOX
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![BU of 3hox by Molmil](/molmil-images/mine/3hox) | Complete RNA polymerase II elongation complex V | 分子名称: | 5'-D(*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*C*AP*AP*GP*TP*AP*GP*TP*TP*AP*AP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*U*CP*AP*AP*CP*CP*AP*GP*GP*CP*UP*U)-3', ... | 著者 | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | 登録日 | 2009-06-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
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3HOU
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![BU of 3hou by Molmil](/molmil-images/mine/3hou) | Complete RNA polymerase II elongation complex I with a T-U mismatch | 分子名称: | 5'-D(*A*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*CP*A*AP*GP*TP*AP*GP*TP*TP*AP*TP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*GP*CP*AP*UP*U*UP*CP*GP*AP*CP*CP*AP*GP*GP*CP*U)-3', ... | 著者 | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | 登録日 | 2009-06-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
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3HOZ
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![BU of 3hoz by Molmil](/molmil-images/mine/3hoz) | Complete RNA polymerase II elongation complex IV with a T-U mismatch and a frayed RNA 3'-guanine | 分子名称: | 5'-D(*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*C*AP*AP*GP*TP*AP*GP*TP*TP*CP*TP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*U*CP*AP*AP*CP*CP*AP*GP*GP*CP*UP*G)-3', ... | 著者 | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | 登録日 | 2009-06-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
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3I4N
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![BU of 3i4n by Molmil](/molmil-images/mine/3i4n) | 8-oxoguanine containing RNA polymerase II elongation complex E | 分子名称: | DNA (5'-D(*AP*G*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*(8OG)P*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Damsma, G.E, Cramer, P. | 登録日 | 2009-07-02 | 公開日 | 2009-09-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Molecular basis of transcriptional mutagenesis at 8-oxoguanine J.Biol.Chem., 284, 2009
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3J0K
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![BU of 3j0k by Molmil](/molmil-images/mine/3j0k) | Orientation of RNA polymerase II within the human VP16-Mediator-pol II-TFIIF assembly | 分子名称: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | 著者 | Bernecky, C, Grob, P, Ebmeier, C.C, Nogales, E, Taatjes, D.J. | 登録日 | 2011-10-04 | 公開日 | 2011-10-19 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (36 Å) | 主引用文献 | Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. Plos Biol., 9, 2011
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8TVQ
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![BU of 8tvq by Molmil](/molmil-images/mine/8tvq) | Cryo-EM structure of CPD stalled 10-subunit Pol II in complex with Rad26 | 分子名称: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | 著者 | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | 登録日 | 2023-08-18 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc.Natl.Acad.Sci.USA, 121, 2024
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4JU3
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![BU of 4ju3 by Molmil](/molmil-images/mine/4ju3) | Crystal structure of hcv ns5b polymerase in complex with compound 8 | 分子名称: | 5-(4-carboxyphenoxy)-2-{[(4-methylphenyl)sulfonyl]amino}benzoic acid, Genome polyprotein, MAGNESIUM ION | 著者 | Coulombe, R. | 登録日 | 2013-03-24 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay. Bioorg.Med.Chem.Lett., 23, 2013
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4JTZ
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![BU of 4jtz by Molmil](/molmil-images/mine/4jtz) | Crystal structure of hcv ns5b polymerase in complex with compound 4 | 分子名称: | 3-{[4-oxo-1-(2,4,6-trifluorobenzyl)-1,4-dihydroquinazolin-6-yl]oxy}-N-(pyridin-3-yl)-2-(trifluoromethyl)benzamide, GLYCEROL, Genome polyprotein, ... | 著者 | Coulombe, R. | 登録日 | 2013-03-24 | 公開日 | 2013-07-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency. J.Med.Chem., 57, 2014
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3KLV
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![BU of 3klv by Molmil](/molmil-images/mine/3klv) | M296I G62S mutant of foot-and-mouth disease virus RNA-polymerase in complex with a template- primer RNA | 分子名称: | 3D polymerase, MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*GP*GP*CP*C)-3'), ... | 著者 | Ferrer-Orta, C, Sierra, M, Agudo, R, Perez-Luque, R, Arias, A, Verdaguer, N. | 登録日 | 2009-11-09 | 公開日 | 2010-07-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin J.Virol., 84, 2010
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3K1F
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![BU of 3k1f by Molmil](/molmil-images/mine/3k1f) | Crystal structure of RNA Polymerase II in complex with TFIIB | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | 著者 | Kostrewa, D, Zeller, M.E, Armache, K.-J, Seizl, M, Leike, K, Thomm, M, Cramer, P. | 登録日 | 2009-09-27 | 公開日 | 2009-11-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | RNA polymerase II-TFIIB structure and mechanism of transcription initiation. Nature, 462, 2009
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7ZWD
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![BU of 7zwd by Molmil](/molmil-images/mine/7zwd) | Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | 登録日 | 2022-05-19 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
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7ZX7
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![BU of 7zx7 by Molmil](/molmil-images/mine/7zx7) | Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (CC) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | 登録日 | 2022-05-20 | 公開日 | 2022-11-30 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
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