3S6F
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3WQH
| Crystal Structure of human DPP-IV in complex with Anagliptin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide | 著者 | Watanabe, Y.S, Okada, S, Motoyama, T, Takahashi, R, Adachi, H, Oka, M. | 登録日 | 2014-01-27 | 公開日 | 2015-07-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions. J Enzyme Inhib Med Chem, 30, 2015
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3WF9
| Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 1-oxo-1-[(4-sulfamoylphenyl)amino]propan-2-yl-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylate | 分子名称: | (2S)-1-oxo-1-[(4-sulfamoylphenyl)amino]propan-2-yl (2S)-2-methyl-1,2,3,4-tetrahydroacridine-9-carboxylate, GLYCEROL, Ribosomal protein S6 kinase beta-1, ... | 著者 | Niwa, H, Shirouzu, M, Yokoyama, S. | 登録日 | 2013-07-17 | 公開日 | 2014-08-06 | 最終更新日 | 2014-10-29 | 実験手法 | X-RAY DIFFRACTION (2.035 Å) | 主引用文献 | Crystal structures of the S6K1 kinase domain in complexes with inhibitors J.Struct.Funct.Genom., 15, 2014
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3WZE
| KDR in complex with ligand sorafenib | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ACETATE ION, ... | 著者 | Okamoto, K, Ikemori_Kawada, M, Inoue, A, Matsui, J. | 登録日 | 2014-09-24 | 公開日 | 2015-05-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization. ACS MED.CHEM.LETT., 6, 2015
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4E0Y
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4E1M
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4E2U
| Crystal Structures of RadAmin intein from Pyrococcus horikoshii | 分子名称: | Pho radA intein | 著者 | Oeemig, J.S, Zhou, D, Kajander, T, Wlodawer, A, Iwai, H. | 登録日 | 2012-03-09 | 公開日 | 2012-05-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.582 Å) | 主引用文献 | NMR and Crystal Structures of the Pyrococcus horikoshii RadA Intein Guide a Strategy for Engineering a Highly Efficient and Promiscuous Intein. J.Mol.Biol., 421, 2012
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4E5Z
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3NOX
| Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl-peptidase 4 (CD26, ... | 著者 | Klei, H.E. | 登録日 | 2010-06-25 | 公開日 | 2010-08-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.338 Å) | 主引用文献 | Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors. J.Med.Chem., 53, 2010
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3O71
| Crystal structure of ERK2/DCC peptide complex | 分子名称: | Mitogen-activated protein kinase 1, Peptide of Deleted in Colorectal Cancer, THIOCYANATE ION | 著者 | Ma, W.F, Shang, Y, Wei, Z.Y, Wen, W.Y, Wang, W.N, Zhang, M.J. | 登録日 | 2010-07-30 | 公開日 | 2011-06-15 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase Structure, 18, 2010
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4ENC
| Crystal structure of fluoride riboswitch | 分子名称: | FLUORIDE ION, Fluoride riboswitch, MAGNESIUM ION, ... | 著者 | Ren, A.M, Rajashankar, K.R, Patel, D.J. | 登録日 | 2012-04-12 | 公開日 | 2012-05-09 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.272 Å) | 主引用文献 | Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch. Nature, 486, 2012
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4ENP
| Structure of E530A variant E. coli KatE | 分子名称: | Catalase HPII, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Loewen, P.C, Jha, V. | 登録日 | 2012-04-13 | 公開日 | 2012-05-09 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Influence of main channel structure on H(2)O(2) access to the heme cavity of catalase KatE of Escherichia coli. Arch.Biochem.Biophys., 526, 2012
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4EY4
| Crystal Structure of Recombinant Human Acetylcholinesterase in the Apo state | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Cheung, J, Rudolph, M, Burshteyn, F, Cassidy, M, Gary, E, Love, J, Height, J, Franklin, M. | 登録日 | 2012-05-01 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.156 Å) | 主引用文献 | Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem., 55, 2012
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4EX9
| Crystal structure of the prealnumycin C-glycosynthase AlnA in complex with ribulose 5-phosphate | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AlnA, CALCIUM ION, ... | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | 登録日 | 2012-04-30 | 公開日 | 2013-01-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proc.Natl.Acad.Sci.USA, 110, 2013
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4EY7
| Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Donepezil | 分子名称: | 1,2-ETHANEDIOL, 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Cheung, J, Rudolph, M, Burshteyn, F, Cassidy, M, Gary, E, Love, J, Height, J, Franklin, M. | 登録日 | 2012-05-01 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3509 Å) | 主引用文献 | Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J.Med.Chem., 55, 2012
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4ERK
| THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE | 分子名称: | EXTRACELLULAR REGULATED KINASE 2, OLOMOUCINE, SULFATE ION | 著者 | Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. | 登録日 | 1998-07-09 | 公開日 | 1999-07-22 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
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3NWX
| X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor | 分子名称: | N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide, SULFATE ION, protease | 著者 | Torbeev, V.Y, Kent, S.B.H. | 登録日 | 2010-07-12 | 公開日 | 2011-11-02 | 最終更新日 | 2019-07-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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4F1P
| Crystal Structure of mutant S554D for ArfGAP and ANK repeat domain of ACAP1 | 分子名称: | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1, SULFATE ION, ... | 著者 | Sun, F, Pang, X, Zhang, K, Ma, J, Zhou, Q. | 登録日 | 2012-05-07 | 公開日 | 2012-07-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mechanistic insights into regulated cargo binding by ACAP1 protein J.Biol.Chem., 287, 2012
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4FS0
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4FV0
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4GDL
| Crystal Structure of Human Atg12~Atg5 Conjugate in Complex with an N-terminal Fragment of Atg16L1 | 分子名称: | Autophagy protein 5, Autophagy-related protein 16-1, SODIUM ION, ... | 著者 | Otomo, C, Metlagel, Z, Takaesu, G, Otomo, T. | 登録日 | 2012-07-31 | 公開日 | 2012-12-05 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.875 Å) | 主引用文献 | Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat.Struct.Mol.Biol., 20, 2013
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4FV6
| Crystal Structure of the ERK2 complexed with E57 | 分子名称: | 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-(2-{[(2S)-1-hydroxybutan-2-yl]amino}-5-methylpyrimidin-4-yl)-1H-pyrrole-2-carboxamide, ... | 著者 | Kang, Y.N, Stuckey, J.A, Xie, X. | 登録日 | 2012-06-29 | 公開日 | 2012-08-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of the ERK2 complexed with E57 TO BE PUBLISHED
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4FUX
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3OR3
| Restriction endonuclease HPY188I in complex with product DNA | 分子名称: | 5'-D(*GP*AP*TP*CP*T)-3', 5'-D(*GP*TP*TP*CP*A)-3', 5'-D(P*GP*AP*AP*C)-3', ... | 著者 | Sokolowska, M, Czapinska, H, Bochtler, M. | 登録日 | 2010-09-06 | 公開日 | 2010-10-20 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Hpy188I-DNA pre- and post-cleavage complexes--snapshots of the GIY-YIG nuclease mediated catalysis. Nucleic Acids Res., 39, 2011
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4FYT
| Human aminopeptidase N (CD13) in complex with amastatin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMASTATIN, ... | 著者 | Wong, A.H, Rini, J.M. | 登録日 | 2012-07-05 | 公開日 | 2012-09-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. J.Biol.Chem., 287, 2012
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