PDB: 66507 件ウェブページステータス検索Chemie searchBIRD

---

6BAH	Trastuzumab Fab v3 with 5-diphenyl meditope variant 分子名称: Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain,IGH@ protein, ... 著者 Bzymek, K.P, King, J.D, Williams, J.C. 登録日 2017-10-12 公開日 2018-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag. Bioconjug. Chem., 29, 2018
6BC6	Cryo X-ray structure of apo AAC-VIa 分子名称: AAC 3-VI protein, MAGNESIUM ION 著者 Cuneo, M.J, Kumar, P. 登録日 2017-10-20 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad. Sci Adv, 4, 2018
4XBT	Crystal Structure of the L74F/M78F/L103V/L114V/I116V/F139V/L147V mutant of LEH complexed with (S,S)-cyclohexanediol 分子名称: (1S,2S)-cyclohexane-1,2-diol, CITRATE ANION, Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-17 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
4XBK	2-deoxyribose-5-phosphate aldolase from Lactobacillus brevis 分子名称: ACETIC ACID, Deoxyribose-phosphate aldolase 著者 Jiao, X.-C, Pan, J, Xu, G.-C, Kong, X.-D, Chen, Q, Zhang, Z.-J, Xu, J.-H. 登録日 2014-12-17 公開日 2015-11-04 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 Efficient synthesis of a statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis Catalysis Science And Technology, 5, 2015
6APP	Anti-Marburgvirus Nucleoprotein Single Domain Antibody A Complexed with Nucleoprotein C-terminal domain 分子名称: Anti-Marburgvirus Nucleoprotein Single Domain Antibody A, Nucleoprotein 著者 Taylor, A.B, Garza, J.A. 登録日 2017-08-17 公開日 2017-10-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Unveiling a Drift Resistant Cryptotope withinMarburgvirusNucleoprotein Recognized by Llama Single-Domain Antibodies. Front Immunol, 8, 2017
4XDV	Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclohexanediol 分子名称: (1R,2R)-cyclohexane-1,2-diol, Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Lonsdale, R, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-20 公開日 2015-07-15 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
7BGX	Mutant F105L of recombinant beta-lactoglobulin 分子名称: Beta-lactoglobulin, GLYCEROL, SULFATE ION 著者 Loch, J.I, Wrobel, P, Lewinski, K. 登録日 2021-01-08 公開日 2021-01-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Interactions of new lactoglobulin variants with tetracaine: crystallographic studies of ligand binding to lactoglobulin mutants possessing single substitution in the binding pocket. Acta Biochim.Pol., 68, 2021
7BTV	Crystal structure of EHMT2 SET domain in complex with compound 5. 分子名称: Histone-lysine N-methyltransferase EHMT2, N~2~-{4-methoxy-3-[3-(pyrrolidin-1-yl)propoxy]phenyl}-N~4~,6-dimethylpyrimidine-2,4-diamine, S-ADENOSYLMETHIONINE, ... 著者 Suzuki, M, Mizuno, T, Katayama, K. 登録日 2020-04-03 公開日 2020-11-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines. Bioorg.Med.Chem.Lett., 30, 2020
6ATW	Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox 分子名称: Chlorotoxin 著者 Gewe, M.M, Rupert, P, Strong, R.K. 登録日 2017-08-29 公開日 2018-02-28 最終更新日 2018-03-14 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat. Struct. Mol. Biol., 25, 2018
4XJ9	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 5.0 in 50mM Sodium Acetate with DMSO as the cryoprotectant 分子名称: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B 著者 Brear, P. 登録日 2015-01-08 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
6AYD	Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide 分子名称: N-[6-(4-hydroxyphenyl)-2H-indazol-3-yl]cyclopropanecarboxamide, Serine/threonine-protein kinase pim-1 著者 Shewchuk, L.M, Henley, Z.A. 登録日 2017-09-08 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 From PIM1 to PI3K delta via GSK3 beta : Target Hopping through the Kinome. ACS Med Chem Lett, 8, 2017
4XKJ	a Novel D-lactate Dehydrogenase from Sporolactobacillus sp 分子名称: D-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Bo, Y, Hui, D, Xiang, L. 登録日 2015-01-12 公開日 2015-08-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.148 Å) 主引用文献 a Novel D-lactate Dehydrogenase from Sporolactobacillus sp To Be Published
4XQM	Crystal structure of the MRH domain of Glucosidase II beta bound to mannose 分子名称: Glucosidase 2 subunit beta, alpha-D-mannopyranose 著者 Olson, L.J, Dahms, N.M, Kim, J.-J.P. 登録日 2015-01-19 公開日 2015-07-22 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.625 Å) 主引用文献 Crystal Structure and Functional Analyses of the Lectin Domain of Glucosidase II: Insights into Oligomannose Recognition. Biochemistry, 54, 2015
2J2I	Crystal Structure of the humab PIM1 in complex with LY333531 分子名称: (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION 著者 Debreczeni, J.E, Bullock, A.N, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S. 登録日 2006-08-16 公開日 2007-02-13 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc. Natl. Acad. Sci. U.S.A., 104, 2007
4XOG	CRYSTAL STRUCTURE OF THE NANB SIALIDASE FROM STREPTOCOCCUS PNEUMONIAE IN COMPLEX WITH Optactin and DANA 分子名称: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, DIMETHYL SULFOXIDE, ... 著者 Brear, P. 登録日 2015-01-16 公開日 2016-02-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XW6	X-ray structure of PKAc with ADP, free phosphate ion, CP20, magnesium ions 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Gerlits, O, Tian, J, Das, A, Taylor, S, Langan, P, Heller, T.W, Kovalevsky, A. 登録日 2015-01-28 公開日 2015-05-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J.Biol.Chem., 290, 2015
6AZL	Structure of cetuximab with aminoheptanoic acid-linked N-carboxyethylarginine meditope variant 分子名称: SULFATE ION, cetuximab Fab heavy chain, cetuximab Fab light chain, ... 著者 Bzymek, K.P, Williams, J.C. 登録日 2017-09-11 公開日 2017-12-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.482 Å) 主引用文献 Meditope-Fab interaction: threading the hole. Acta Crystallogr F Struct Biol Commun, 73, 2017
7BQY	THE CRYSTAL STRUCTURE OF COVID-19 MAIN PROTEASE IN COMPLEX WITH AN INHIBITOR N3 at 1.7 angstrom 分子名称: 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE 著者 Liu, X, Zhang, B, Jin, Z, Yang, H, Rao, Z. 登録日 2020-03-26 公開日 2020-04-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of Mprofrom SARS-CoV-2 and discovery of its inhibitors. Nature, 582, 2020
4XBY	Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclopentene oxide 分子名称: (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase 著者 Kong, X.D, Sun, Z, Xu, J.H, Reetz, M.T, Zhou, J. 登録日 2014-12-17 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution Angew.Chem.Int.Ed.Engl., 54, 2015
5D1M	Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A) 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ... 著者 Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. 登録日 2015-08-04 公開日 2015-10-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.581 Å) 主引用文献 Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
6BDQ	Schistosoma mansoni (Blood Fluke) Sulfotransferase/CIDD-0000074 (Compound 10a) Complex 分子名称: (2-nitro-4-{[(3S)-piperidin-3-yl]amino}phenyl)methanol, ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase oxamniquine resistance protein 著者 Taylor, A.B. 登録日 2017-10-24 公開日 2018-10-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents. ACS Med Chem Lett, 9, 2018
4XIO	Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 8.0 with MPD as the cryoprotectant 分子名称: Sialidase B 著者 Brear, P. 登録日 2015-01-07 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
7A16	CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR GSK2229238A (COMPOUND 43) 分子名称: 5,6-bis(fluoranyl)-3-(4-piperazin-1-yl-2-propan-2-yloxy-phenyl)-1~{H}-indole-2-carboxamide, MANGANESE (II) ION, Methionine aminopeptidase 2, ... 著者 Thorpe, J.H. 登録日 2020-08-11 公開日 2020-09-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'. Bioorg.Med.Chem.Lett., 30, 2020
4XJU	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid 分子名称: (1R,2R,3R,4R,5R,7R)-2-(acetylamino)-7-[(1R)-1,2-dihydroxyethyl]-4-fluoro-3-hydroxy-6,8-dioxabicyclo[3.2.1]octane-5-carboxylic acid, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Brear, P. 登録日 2015-01-09 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
5D6N	Crystal structure of a mycobacterial protein 分子名称: Acyl-CoA synthase 著者 Li, W.J, Bi, L.J. 登録日 2015-08-12 公開日 2016-03-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria. Sci Rep, 5, 2015

<473474475476477478479480481482483484485486487488>