PDB: 35140 件ウェブページステータス検索Chemie searchBIRD

---

3ZSI	X-ray structure of p38alpha bound to VX-745 分子名称: 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one, MITOGEN-ACTIVATED PROTEIN KINASE 14, octyl beta-D-glucopyranoside 著者 Azevedo, R, van Zeeland, M, Raaijmakers, H, Kazemier, B, Oubrie, A. 登録日 2011-06-28 公開日 2012-06-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 X-ray structure of p38 alpha bound to TAK-715: comparison with three classic inhibitors. Acta Crystallogr. D Biol. Crystallogr., 68, 2012
3ZS5	Structural basis for kinase selectivity of three clinical p38alpha inhibitors 分子名称: 1,2-ETHANEDIOL, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, MITOGEN-ACTIVATED PROTEIN KINASE 14, ... 著者 Azevedo, R, van Zeeland, M, Raaijmakers, H.C.A, Kazemier, B, Oubrie, A. 登録日 2011-06-23 公開日 2012-07-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 X-ray structure of p38 alpha bound to TAK-715: comparison with three classic inhibitors. Acta Crystallogr. D Biol. Crystallogr., 68, 2012
3JRZ	CcdBVfi-FormII-pH5.6 分子名称: CcdB 著者 De Jonge, N, Buts, L, Loris, R. 登録日 2009-09-09 公開日 2009-12-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and thermodynamic characterization of vibrio fischeri CCDB J.Biol.Chem., 285, 2010
3KQ7	Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide 分子名称: ACETATE ION, Mitogen-activated protein kinase p38 alpha, N-(2-methyl-5-{[(2-morpholin-4-ylpyridin-4-yl)carbonyl]amino}phenyl)-6-({2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}amino)py ridine-3-carboxamide 著者 Cheng, R.K.Y, Barker, J, Whittaker, M. 登録日 2009-11-17 公開日 2009-12-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide TO BE PUBLISHED
3ZSH	X-ray structure of p38alpha bound to SCIO-469 分子名称: 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide, MITOGEN-ACTIVATED PROTEIN KINASE 14, octyl beta-D-glucopyranoside 著者 Azevedo, R, van Zeeland, M, Raaijmakers, H, Kazemier, B, Oubrie, A. 登録日 2011-06-28 公開日 2012-06-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 X-ray structure of p38 alpha bound to TAK-715: comparison with three classic inhibitors. Acta Crystallogr. D Biol. Crystallogr., 68, 2012
3KZ5	Structure of cdomain 分子名称: ACETATE ION, Protein sopB 著者 Schumacher, M.A. 登録日 2009-12-07 公開日 2010-03-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes. Nucleic Acids Res., 38, 2010
6GG3	Crystal structure of M2 PYK in complex with Alanine. 分子名称: ALANINE, PHOSPHATE ION, Pyruvate kinase PKM 著者 McNae, I.W, Yuan, M, Walkinshaw, M.D. 登録日 2018-05-02 公開日 2019-09-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.72 Å) 主引用文献 An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor. Biochem.J., 475, 2018
1ZYJ	Human P38 MAP Kinase in Complex with Inhibitor 1a 分子名称: 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Karpusas, M, Michelotti, E.L, Springman, E.B. 登録日 2005-06-10 公開日 2005-11-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg.Med.Chem.Lett., 15, 2005
1ZZ2	Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes 分子名称: Mitogen-activated protein kinase 14, N-[3-(4-FLUOROPHENOXY)PHENYL]-4-[(2-HYDROXYBENZYL)AMINO]PIPERIDINE-1-SULFONAMIDE, octyl beta-D-glucopyranoside 著者 Michelotti, E.L, Moffett, K.K, Springman, E.B, Karpusas, M. 登録日 2005-06-13 公開日 2005-10-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg.Med.Chem.Lett., 15, 2005
4A8D	DegP dodecamer with bound OMP 分子名称: OUTER MEMBRANE PROTEIN C, PERIPLASMIC SERINE ENDOPROTEASE DEGP 著者 Malet, H, Krojer, T, Sawa, J, Schafer, E, Saibil, H.R, Ehrmann, M, Clausen, T. 登録日 2011-11-20 公開日 2012-01-11 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (28 Å) 主引用文献 Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq Nat.Struct.Mol.Biol., 19, 2012
4AAC	P38ALPHA MAP KINASE BOUND TO CMPD 29 分子名称: CHLORIDE ION, MITOGEN-ACTIVATED PROTEIN KINASE 14, N-isoxazol-3-yl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxo-quinazolin-3-yl]benzamide 著者 Gerhardt, S, Hargreaves, D. 登録日 2011-12-01 公開日 2012-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012
6WJD	SA-like state of human 26S Proteasome with non-cleavable M1-linked hexaubiquitin and E3 ubiquitin ligase E6AP/UBE3A 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... 著者 Chen, X, Walters, K.J. 登録日 2020-04-13 公開日 2020-08-05 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome. Structure, 28, 2020
3UTM	Crystal structure of a mouse Tankyrase-Axin complex 分子名称: Axin-1, Tankyrase-1 著者 Cheng, Z, Morrone, S, Xu, W. 登録日 2011-11-26 公開日 2012-01-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment. Proc.Natl.Acad.Sci.USA, 109, 2012
6GMA	Crystal structure of the FIP200 C-terminal region 分子名称: RB1-inducible coiled-coil protein 1 著者 Witt, M, Bock, T, Daumke, O. 登録日 2018-05-24 公開日 2019-03-06 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol.Cell, 74, 2019
6GY5	Crystal structure of the kelch domain of human KLHL20 in complex with DAPK1 peptide 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Death-associated protein kinase 1, ... 著者 Chen, Z, Hozjan, V, Strain-Damerell, C, Williams, E, Wang, D, Cooper, C.D.O, Sanvitale, C.E, Fairhead, M, Carpenter, E.P, Pike, A.C.W, Krojer, T, Srikannathasan, V, Sorrell, F, Johansson, C, Mathea, S, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. 登録日 2018-06-28 公開日 2018-08-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.086 Å) 主引用文献 Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase. Structure, 27, 2019
6GZC	heterotetrameric katanin p60:p80 complex 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Katanin p60 ATPase-containing subunit A1, ... 著者 Faltova, L, Jiang, K, Frey, D, Wu, Y, Capitani, G, Prota, A.E, Akhmanova, A, Steinmetz, M.O, Kammerer, R.A. 登録日 2018-07-03 公開日 2019-08-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex. Structure, 27, 2019
3L8S	Human p38 MAP Kinase in Complex with CP-547632 分子名称: 3-[(4-bromo-2,6-difluorobenzyl)oxy]-5-{[(4-pyrrolidin-1-ylbutyl)carbamoyl]amino}isothiazole-4-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Rauh, D. 登録日 2010-01-03 公開日 2010-03-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132, 2010
6H02	Crystal structure of human Mediator subunit MED23 分子名称: LAMA nanobody NB106, Mediator of RNA polymerase II transcription subunit 23 著者 Clantin, B, Monte, D, Villeret, V. 登録日 2018-07-06 公開日 2018-08-29 最終更新日 2018-09-05 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of human Mediator subunit MED23. Nat Commun, 9, 2018
1YX6	Solution Structure of S5a UIM-2/Ubiquitin Complex 分子名称: 26S proteasome non-ATPase regulatory subunit 4, Ubiquitin 著者 Wang, Q, Young, P, Walters, K.J. 登録日 2005-02-19 公開日 2005-04-19 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of S5a Bound to Monoubiquitin Provides a Model for Polyubiquitin Recognition J.Mol.Biol., 348, 2005
3WUP	Crystal Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Polymerase Eta 分子名称: CHLORIDE ION, DNA polymerase eta, GLYCEROL, ... 著者 Suzuki, N, Wakatsuki, S, Kawasaki, S. 登録日 2014-05-01 公開日 2015-06-17 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1. Febs J., 283, 2016
1ZHB	Crystal Structure Of The Murine Class I Major Histocompatibility Complex Of H-2Db, B2-Microglobulin, and a 9-Residue Peptide Derived from rat dopamine beta-monooxigenase 分子名称: 9-mer peptide from Dopamine beta-monooxygenase, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... 著者 Sandalova, T, Michaelsson, J, Harris, R.A, Odeberg, J, Schneider, G, Karre, K, Achour, A. 登録日 2005-04-25 公開日 2005-06-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity J.Biol.Chem., 280, 2005
4AA4	P38ALPHA MAP KINASE BOUND TO CMPD 22 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[4-METHYL-3-[6-(4-METHYLPIPERAZIN-1-YL)-4-OXIDANYLIDENE-QUINAZOLIN-3-YL]PHENYL]FURAN-3-CARBOXAMIDE 著者 Gerhardt, S, Hargreaves, D. 登録日 2011-11-30 公開日 2012-05-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012
1XWE	NMR Structure of C345C (NTR) domain of C5 of complement 分子名称: Complement C5 著者 Bramham, J, Thai, C.-T, Soares, D.C, Uhrin, D, Ogata, R.T, Barlow, P.N. 登録日 2004-10-30 公開日 2004-12-21 最終更新日 2021-11-10 実験手法 SOLUTION NMR 主引用文献 Functional Insights from the Structure of the Multifunctional C345C Domain of C5 of Complement J.Biol.Chem., 280, 2005
3X0W	Crystal structure of PLEKHM1 LIR-fused human LC3B_2-119 分子名称: Microtubule-associated proteins 1A/1B light chain 3B 著者 Suzuki, H, McEwan, D.G, Popovic, D, Gubas, A, Terawaki, S, Stadel, D, Coxon, F, Stegmann, D.M, Bhogaraju, S, Maddi, K, Kirchhoff, A, Gatti, E, Helfrich, M.H, Behrends, C, Pierre, P, Dikic, I, Wakatsuki, S. 登録日 2014-10-22 公開日 2015-01-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. Mol.Cell, 57, 2015
4AJY	von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide 分子名称: GLYCEROL, HYPOXIA-INDUCIBLE FACTOR 1-ALPHA, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... 著者 Van Molle, I, Thomann, A, Buckley, D.L, So, E.C, Lang, S, Crews, C.M, Ciulli, A. 登録日 2012-02-21 公開日 2012-11-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Dissecting Fragment-Based Lead Discovery at the Von Hippel-Lindau Protein:Hypoxia Inducible Factor 1Alpha Protein-Protein Interface. Chem.Biol., 19, 2012

<469470471472473474475476477478479480481482483484>