PDB: 2561 件ウェブページステータス検索Chemie searchBIRD

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1FGS	FOLYLPOLYGLUTAMATE SYNTHETASE FROM LACTOBACILLUS CASEI 分子名称: FOLYLPOLYGLUTAMATE SYNTHETASE, MAGNESIUM ION, PYROPHOSPHATE 2- 著者 Sun, X, Bognar, A, Baker, E, Smith, C. 登録日 1998-04-29 公開日 1999-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase. Proc.Natl.Acad.Sci.USA, 95, 1998
8BB1	T3 SAM lyase in complex with S-adenosylmethionine synthase 分子名称: CHLORIDE ION, S-Adenosylmethionine lyase, S-adenosylmethionine synthase 著者 Triguis, S, Selmer, M. 登録日 2022-10-12 公開日 2023-08-23 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase. Cell Rep, 42, 2023
4YCW	Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant 分子名称: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ... 著者 Fang, P, Wang, J, Guo, M. 登録日 2015-02-20 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor Chem.Biol., 22, 2015
6PFN	Succinyl-CoA synthase from Francisella tularensis 分子名称: 1,2-ETHANEDIOL, ACETATE ION, COENZYME A, ... 著者 Osipiuk, J, Maltseva, N, Jedrzejczak, R, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2019-06-21 公開日 2019-07-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Succinyl-CoA synthase from Francisella tularensis to be published
3ZYY	Reductive activator for corrinoid,iron-sulfur protein 分子名称: (R,R)-2,3-BUTANEDIOL, FE2/S2 (INORGANIC) CLUSTER, IRON-SULFUR CLUSTER BINDING PROTEIN, ... 著者 Hennig, S.E, Jeoung, J.-H, Goetzl, S, Dobbek, H. 登録日 2011-08-30 公開日 2012-04-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Redox-Dependent Complex Formation by an ATP-Dependent Activator of the Corrinoid/Iron-Sulfur Protein. Proc.Natl.Acad.Sci.USA, 109, 2012
6TCU	Glycogen synthase kinase-3 beta (GSK3b) in complex with ligand 1 分子名称: 5-[2,3-bis(fluoranyl)phenyl]-~{N}-[[1-(2-methoxyethyl)piperidin-4-yl]methyl]-1~{H}-indazole-3-carboxamide, ACETATE ION, Glycogen synthase kinase-3 beta 著者 Lammens, A, Krapp, S, Buonfiglio, R, Ombrato, R. 登録日 2019-11-06 公開日 2020-09-16 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue andIn VivoActivity in a Mood Disorder Model. Acs Med.Chem.Lett., 11, 2020
6MGG	Succinyl-CoA synthase from Francisella tularensis, phosphorylated, in complex with CoA 分子名称: 1,2-ETHANEDIOL, COENZYME A, MAGNESIUM ION, ... 著者 Osipiuk, J, Maltseva, N, Jedrzejczak, R, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2018-09-13 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Succinyl-CoA synthase from Francisella tularensis to be published
1GNG	Glycogen synthase kinase-3 beta (GSK3) complex with FRATtide peptide 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FRATTIDE, GLYCOGEN SYNTHASE KINASE-3 BETA, ... 著者 Bax, B, Carter, P.S, Lewis, C, Guy, A.R, Bridges, A, Tanner, R, Pettman, G, Mannix, C, Culbert, A.A, Brown, M.J.B, Smith, D.G, Reith, A.D. 登録日 2001-10-04 公開日 2002-10-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation Structure, 9, 2001
1BXR	STRUCTURE OF CARBAMOYL PHOSPHATE SYNTHETASE COMPLEXED WITH THE ATP ANALOG AMPPNP 分子名称: CARBAMOYL-PHOSPHATE SYNTHASE, CHLORIDE ION, L-ornithine, ... 著者 Thoden, J.B, Wesenberg, G, Raushel, F.M, Holden, H.M. 登録日 1998-10-08 公開日 1999-04-20 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding. Biochemistry, 38, 1999
1I09	STRUCTURE OF GLYCOGEN SYNTHASE KINASE-3 (GSK3B) 分子名称: GLYCOGEN SYNTHASE KINASE-3 BETA, PHOSPHATE ION 著者 Ter Haar, E, Coll, J.T, Jain, J. 登録日 2001-01-29 公開日 2002-01-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of GSK3beta reveals a primed phosphorylation mechanism. Nat.Struct.Biol., 8, 2001
6MEL	Succinyl-CoA synthase from Campylobacter jejuni 分子名称: CHLORIDE ION, CITRIC ACID, Succinate--CoA ligase [ADP-forming] subunit beta, ... 著者 Osipiuk, J, Maltseva, N, Jedrzejczak, R, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2018-09-06 公開日 2018-09-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Succinyl-CoA synthase from Campylobacter jejuni to be published
1BYI	STRUCTURE OF APO-DETHIOBIOTIN SYNTHASE AT 0.97 ANGSTROMS RESOLUTION 分子名称: DETHIOBIOTIN SYNTHASE 著者 Sandalova, T, Schneider, G, Kaeck, H, Lindqvist, Y. 登録日 1998-10-15 公開日 1999-06-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (0.97 Å) 主引用文献 Structure of dethiobiotin synthetase at 0.97 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
1KP2	Crystal Structure of E. coli Argininosuccinate Synthetase in Complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANIDINE, PHOSPHATE ION, ... 著者 Lemke, C.T, Howell, P.L. 登録日 2001-12-27 公開日 2002-04-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Substrate Induced Conformational Changes in Argininosuccinate Synthetase J.Biol.Chem., 277, 2002
1KP3	Crystal Structure of E. coli Argininosuccinate Synthetase in Complex with ATP and Citrulline 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CITRULLINE, GUANIDINE, ... 著者 Lemke, C.T, Howell, P.L. 登録日 2001-12-27 公開日 2002-04-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Substrate Induced Conformational Changes in Argininosuccinate Synthetase J.Biol.Chem., 277, 2002
6H0U	Glycogen synthase kinase-3 beta (GSK3) complex with a covalent [1,2,4]triazolo[1,5-a][1,3,5]triazine inhibitor 分子名称: (2~{R})-3-[7-azanyl-5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-2-yl]-2-cyano-propanamide, CHLORIDE ION, GLYCEROL, ... 著者 Marcovich, I, Demitri, N, De Zorzi, R, Storici, P. 登録日 2018-07-10 公開日 2019-05-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A Triazolotriazine-Based Dual GSK-3 beta /CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. Chemmedchem, 14, 2019
7OY9	Crystal structure of GMP reductase from mycobacterium smegmatis. 分子名称: Guanosine 5'-monophosphate reductase 著者 Dolezal, M, Klima, M, Pichova, I. 登録日 2021-06-24 公開日 2022-04-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-beta-synthase domain. Febs J., 289, 2022
6FM1	Deoxyguanylosuccinate synthase (DgsS) quaternary structure with ATPanddGMP at 2.3 Angstrom resolution 分子名称: 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Adenylosuccinate synthetase, ... 著者 Sleiman, D, Loc'h, J, Haouz, A, Kaminski, P.A. 登録日 2018-01-29 公開日 2019-06-12 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes. Science, 372, 2021
4EJN	Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide 分子名称: 1,2-ETHANEDIOL, 2-BUTANOL, N-(4-{5-[3-(acetylamino)phenyl]-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl}benzyl)-3-fluorobenzamide, ... 著者 Eathiraj, S. 登録日 2012-04-06 公開日 2012-05-23 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. J.Med.Chem., 55, 2012
7F5U	Drosophila P5CS filament with glutamate and ATPgammaS 分子名称: Delta-1-pyrroline-5-carboxylate synthase 著者 Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. 登録日 2021-06-22 公開日 2022-04-06 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of dynamic P5CS filaments. Elife, 11, 2022
4U0M	Structure of the Vibrio cholerae di-nucleotide cyclase (DncV) mutant D193N in complex with ATP, GTP and 5MTHFGLU2 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic AMP-GMP synthase, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Zhu, D, Xiang, Y. 登録日 2014-07-12 公開日 2014-09-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates. Mol.Cell, 55, 2014
5F95	Crystal structure of GSK3b in complex with Compound 18: 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide 分子名称: 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide, Glycogen synthase kinase-3 beta 著者 Lewis, H.A, Kish, K, Luo, G, Dubowchick, G.M. 登録日 2015-12-09 公開日 2016-02-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.525 Å) 主引用文献 Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. J.Med.Chem., 59, 2016
5F94	Crystal structure of GSK3b in complex with Compound 15: 2-[(cyclopropylcarbonyl)amino]-N-(4-methoxypyridin-3-yl)pyridine-4-carboxamide 分子名称: 2-[(cyclopropylcarbonyl)amino]-N-(4-methoxypyridin-3-yl)pyridine-4-carboxamide, Glycogen synthase kinase-3 beta 著者 Lewis, H.A, Kish, K, Luo, G, Dubowchick, G.M. 登録日 2015-12-09 公開日 2016-02-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. J.Med.Chem., 59, 2016
6JP9	Crsytal structure of a XMP complexed ATPPase subunit of M. jannaschii GMP synthetase 分子名称: GMP synthase [glutamine-hydrolyzing] subunit B, MALONIC ACID, TRIETHYLENE GLYCOL, ... 著者 Shivakumarasamy, S, Balaram, H. 登録日 2019-03-26 公開日 2020-04-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mechanistic Insights into the Functioning of a Two-Subunit GMP Synthetase, an Allosterically Regulated, Ammonia Channeling Enzyme. Biochemistry, 61, 2022
4XJ6	Crystal structure of Escherichia coli DncV 3'-deoxy GTP bound form 分子名称: 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, VC0179-like protein 著者 Kato, K, Ishii, R, Ishitani, R, Nureki, O. 登録日 2015-01-08 公開日 2015-04-29 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase Structure, 23, 2015
6CVV	Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with adenosine triphosphate (ATP) - promiscuous binding mode with disordered nucleoside 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION 著者 Thompson, A.P, Wegener, K.L, Bruning, J.B, Polyak, S.W. 登録日 2018-03-29 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes Acs Catalysis, 8(11), 2018

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