PDB: 71589 件ウェブページステータス検索Chemie searchBIRD

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7MYU	BACE-1 in complex with compound #22 分子名称: Beta-secretase 1, N-{3-[(4aR,7aS)-2-amino-6-(5-fluoropyrimidin-2-yl)-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide, SULFATE ION 著者 Hendle, J, Timm, D.E, Stout, S.L. 登録日 2021-05-21 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor. J.Med.Chem., 64, 2021
7MYI	BACE-1 in complex with compound #6 分子名称: (4aR,7aR)-6-(pyrimidin-2-yl)-7a-(thiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-amine, Beta-secretase 1, GLYCEROL 著者 Hendle, J, Timm, D.E, Stout, S.L. 登録日 2021-05-21 公開日 2021-07-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor. J.Med.Chem., 64, 2021
2G0C	Structure of the RNA binding domain (residues 404-479) of the Bacillus subtilis YxiN protein 分子名称: ATP-dependent RNA helicase dbpA, SULFATE ION 著者 McKay, D.B. 登録日 2006-02-11 公開日 2006-04-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The domain of the Bacillus subtilis DEAD-box helicase YxiN that is responsible for specific binding of 23S rRNA has an RNA recognition motif fold. RNA, 12, 2006
3MJ9	Crystal structure of JAML in complex with the stimulatory antibody HL4E10 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Junctional adhesion molecule-like, STIMULATORY HAMSTER ANTIBODY HL4E10 FAB HEAVY CHAIN, ... 著者 Verdino, P, Wilson, I.A. 登録日 2010-04-12 公開日 2011-02-23 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Molecular insights into gamma delta T cell costimulation by an anti-JAML antibody. Structure, 19, 2011
7Z8V	CAND1-SCF-SKP2 (SKP1deldel) CAND1 engaged SCF rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-18 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
7Z8T	CAND1-SCF-SKP2 CAND1 engaged SCF rocked 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-18 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
4V48	Real space refined coordinates of the 30S and 50S subunits fitted into the low resolution cryo-EM map of the initiation-like state of E. coli 70S ribosome 分子名称: 16S RIBOSOMAL RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... 著者 Gao, H, Sengupta, J, Valle, M, Korostelev, A, Eswar, N, Stagg, S.M, Van Roey, P, Agrawal, R.K, Harvey, S.T, Sali, A, Chapman, M.S, Frank, J. 登録日 2003-05-06 公開日 2014-07-09 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (11.5 Å) 主引用文献 Study of the structural dynamics of the E. coli 70S ribosome using real space refinement Cell(Cambridge,Mass.), 113, 2003
7ZBW	CAND1-SCF-SKP2 CAND1 rolling-2 SCF engaged 分子名称: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Schulman, B.A. 登録日 2022-03-24 公開日 2023-04-19 最終更新日 2023-05-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. Cell, 186, 2023
7N8N	Melbournevirus nucleosome like particle 分子名称: DNA (147-MER), Histone H2B-H2A doublet, Histone H4-H3 doublet 著者 Liu, Y, Toner, C.M, Zhou, K, Bowerman, S, Luger, K. 登録日 2021-06-15 公開日 2021-08-04 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Virus-encoded histone doublets are essential and form nucleosome-like structures. Cell, 184, 2021
5I0S	Thiosulfate bound Cysteine Dioxygenase at pH 6.2 分子名称: Cysteine dioxygenase type 1, FE (III) ION, THIOSULFATE 著者 Kean, K.M, Driggers, C.M, Karplus, P.A. 登録日 2016-02-04 公開日 2016-12-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
7N9T	CryoEM structure of SARS-CoV-2 Spike in complex with Nb17 分子名称: Nanobody Nb17, Spike glycoprotein 著者 Huang, W, Taylor, D. 登録日 2021-06-18 公開日 2021-08-11 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes Nat Commun, 12, 2021
4E4T	Crystal structure of Phosphoribosylaminoimidazole carboxylase, ATPase subunit from Burkholderia ambifaria 分子名称: Phosphoribosylaminoimidazole carboxylase, ATPase subunit, SULFATE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-03-13 公開日 2012-03-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
3M7N	archaeoglobus fulgidus exosome with RNA bound to the active site 分子名称: 5'-R(*C*UP*CP*CP*CP*C)-3', Probable exosome complex exonuclease 1, Probable exosome complex exonuclease 2, ... 著者 Hartung, S, Hopfner, K.-P. 登録日 2010-03-16 公開日 2010-04-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Quantitative analysis of processive RNA degradation by the archaeal RNA exosome Nucleic Acids Res., 38, 2010
3M86	Crystal structure of the cysteine protease inhibitor, EhICP2, from Entamoeba histolytica 分子名称: Amoebiasin-2, CHLORIDE ION, PENTAETHYLENE GLYCOL, ... 著者 Lara-Gonzalez, S, Casados-Vazquez, L.E, Brieba, L.G. 登録日 2010-03-17 公開日 2011-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the cysteine protease inhibitor 2 from Entamoeba histolytica: functional convergence of a common protein fold. Gene, 471, 2011
2GHU	Crystal structure of falcipain-2 from Plasmodium falciparum 分子名称: falcipain 2 著者 Hogg, T, Nagarajan, K, Schmidt, C.L, Hilgenfeld, R. 登録日 2006-03-27 公開日 2006-06-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum. J.Biol.Chem., 281, 2006
4UR8	Crystal structure of keto-deoxy-D-galactarate dehydratase complexed with 2-oxoadipic acid 分子名称: 2-OXOADIPIC ACID, FORMIC ACID, KETO-DEOXY-D-GALACTARATE DEHYDRATASE 著者 Taberman, H, Parkkinen, T, Hakulinen, N, Rouvinen, J. 登録日 2014-06-26 公開日 2014-12-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.097 Å) 主引用文献 Structure and Function of a Decarboxylating Agrobacterium Tumefaciens Keto-Deoxy-D-Galactarate Dehydratase. Biochemistry, 53, 2014
3MDX	Crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from Brucella melitensis, rhombohedral crystal form 分子名称: 1,2-ETHANEDIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-03-31 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from Brucella melitensis, rhombohedral crystal form To be Published
4V4H	Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic kasugamyin at 3.5A resolution. 分子名称: (1S,2R,3S,4R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL 2-AMINO-4-{[CARBOXY(IMINO)METHYL]AMINO}-2,3,4,6-TETRADEOXY-ALPHA-D-ARABINO-HEXOPYRANOSIDE, 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, ... 著者 Schuwirth, B.S, Vila-Sanjurjo, A, Cate, J.H.D. 登録日 2006-08-04 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 Structural analysis of kasugamycin inhibition of translation. Nat.Struct.Mol.Biol., 13, 2006
5I25	human recombinant coagulation FXI in complex with a peptide derived from human high molecular weight kininogen (HKP) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ASN-PRO-ILE-SER-ASP-PHE-PRO-ASP, Coagulation factor XI 著者 Hall, G.A.F, Wong, S.S, Emsley, J. 登録日 2016-02-08 公開日 2016-04-06 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain. Blood, 127, 2016
4EQY	Crystal structure of Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase from Burkholderia thailandensis 分子名称: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, HIS-HIS-HIS peptide 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-04-19 公開日 2012-05-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
5IR5	Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group P21212 at 1.9 A resolution 分子名称: (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradec-5-enoyloxy)propyl (11Z)-octadec-11-enoate, Arachidonate 15-lipoxygenase, FE (II) ION, ... 著者 Kalms, J, Banthiya, S, Galemou Yoga, E, Kuhn, H, Scheerer, P. 登録日 2016-03-12 公開日 2016-08-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and functional basis of phospholipid oxygenase activity of bacterial lipoxygenase from Pseudomonas aeruginosa. Biochim.Biophys.Acta, 1861, 2016
3MNR	Crystal Structure of Benzamide SNX-1321 bound to Hsp90 分子名称: 2-[(3,4,5-trimethoxyphenyl)amino]-4-(2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide, Heat shock protein HSP 90-alpha 著者 Veal, J.M, Fadden, P, Huang, K.H, Rice, J, Hall, S.E, Haytstead, T.A. 登録日 2010-04-22 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90. Chem.Biol., 17, 2010
7Z6O	X-Ray studies of Ku70/80 reveal the binding site for IP6 分子名称: DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... 著者 Varela, P.F, Charbonnier, J.B. 登録日 2022-03-14 公開日 2023-08-30 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
5I0R	D-cysteine bound C93A mutant of Cysteine Dioxygenase at pH 8 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, D-CYSTEINE, ... 著者 Kean, K.M, Driggers, C.M, Karplus, P.A. 登録日 2016-02-04 公開日 2016-12-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
2GH0	Growth factor/receptor complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GDNF family receptor alpha-3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wang, X.Q. 登録日 2006-03-24 公開日 2006-06-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006

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