6KJJ
| Functional and structural insights into the unusual oxyanion hole-like geometry in macrolactin acyltransferase selective for dicarboxylic acyl donors | 分子名称: | 4-(2-acetamidoethylsulfanyl)-4-oxidanylidene-butanoic acid, Putative beta-lactamase | 著者 | Xiao, F, Dong, S, Feng, Y, Li, W. | 登録日 | 2019-07-22 | 公開日 | 2020-07-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.492 Å) | 主引用文献 | Structural Basis of Specificity for Carboxyl-Terminated Acyl Donors in a Bacterial Acyltransferase. J.Am.Chem.Soc., 142, 2020
|
|
6KKG
| Crystal structure of MAGI2-Dendrin complex | 分子名称: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, Peptide from Dendrin | 著者 | Zhu, J.W, Zhang, H.J, Lin, L, Zhang, R.G. | 登録日 | 2019-07-25 | 公開日 | 2020-07-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Phase separation of MAGI2-mediated complex underlies formation of slit diaphragm complex in glomerular filtration barrier To Be Published
|
|
6KKM
| Crystal structure of RbcL-Raf1 complex from Anabaena sp. PCC 7120 | 分子名称: | All5250 protein, Ribulose bisphosphate carboxylase large chain | 著者 | Xia, L.Y, Jiang, Y.L, Kong, W.W, Chen, Y, Zhou, C.Z. | 登録日 | 2019-07-26 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1. Nat.Plants, 6, 2020
|
|
6KCN
| Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4 | 分子名称: | 3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)isochromen-1-one, GLYCEROL, LYSINE, ... | 著者 | Zhou, J, Fang, P. | 登録日 | 2019-06-28 | 公開日 | 2020-04-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15, 2020
|
|
6KDR
| |
6KE0
| Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor | 分子名称: | 2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-[(2S)-2-methyl-1,2-dihydroimidazo[1,2-a]benzimidazol-3-yl]ethanone, MAGNESIUM ION, ZINC ION, ... | 著者 | Amano, Y, Honbou, K. | 登録日 | 2019-07-03 | 公開日 | 2019-08-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors. Bioorg.Med.Chem., 27, 2019
|
|
6KLR
| |
6KG2
| Human MTHFD2 in complex with Compound 18 | 分子名称: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, N-[2-chloranyl-4-[[7-methyl-8-(4-methylpiperazin-1-yl)-5-oxidanylidene-2,4-dihydro-1H-chromeno[3,4-c]pyridin-3-yl]carbonyl]phenyl]methanesulfonamide, ... | 著者 | Suzuki, M, Matsui, Y, Ota, M, Kawai, J. | 登録日 | 2019-07-10 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity. J.Med.Chem., 62, 2019
|
|
6KMH
| The crystal structure of CASK/Mint1 complex | 分子名称: | Amyloid-beta A4 precursor protein-binding family A member 1, CHLORIDE ION, IODIDE ION, ... | 著者 | Li, W, Feng, W. | 登録日 | 2019-07-31 | 公開日 | 2020-08-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion. Cell Discov, 6, 2020
|
|
6KHM
| Lipase (Open form) | 分子名称: | Hydrolase, alpha/beta domain protein, heptane-1,1-diol, ... | 著者 | Kim, H.J, Kwon, A.R. | 登録日 | 2019-07-16 | 公開日 | 2020-07-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Closed, blocked, and open states of lipase from type II Cutibacterium acnes To Be Published
|
|
6KJE
| lovastatin esterase PcEST in complex with monacolin J | 分子名称: | (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid, ACETATE ION, Pc15g00720 protein, ... | 著者 | Liang, Y.J, Lu, X.F. | 登録日 | 2019-07-22 | 公開日 | 2019-12-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.484 Å) | 主引用文献 | Structural insights into the catalytic mechanism of lovastatin hydrolase J.Biol.Chem., 2019
|
|
6JVM
| Crystal structure of human MTH1 in complex with compound MI1016 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, N4-cyclopropyl-5-ethyl-6-piperidin-1-yl-pyrimidine-2,4-diamine | 著者 | Peng, C, Li, Y.H, Cheng, Y.S. | 登録日 | 2019-04-17 | 公開日 | 2020-10-28 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.098 Å) | 主引用文献 | Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity. Bioorg.Chem., 110, 2021
|
|
6JW9
| |
6KM8
| Crystal Structure of Momordica charantia 7S globulin | 分子名称: | 7S globulin, ACETATE ION, COPPER (II) ION | 著者 | Kesari, P, Pratap, S, Dhankhar, P, Dalal, V, Kumar, P. | 登録日 | 2019-07-31 | 公開日 | 2020-02-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.099 Å) | 主引用文献 | Structural characterization and in-silico analysis of Momordica charantia 7S globulin for stability and ACE inhibition. Sci Rep, 10, 2020
|
|
6JST
| |
6JX3
| |
6JXP
| |
6K0R
| Ruvbl1-Ruvbl2 with truncated domain II in complex with phosphorylated Cordycepin | 分子名称: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Zhang, W, Chen, L, Li, W, Ju, D, Huang, N, Zhang, E. | 登録日 | 2019-05-07 | 公開日 | 2020-05-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | 主引用文献 | Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals. Sci Transl Med, 12, 2020
|
|
6KBZ
| |
5ZKA
| Crystal structure of N-acetylneuraminate lyase from Fusobacterium nucleatum complexed with Pyruvate | 分子名称: | 1,2-ETHANEDIOL, N-acetylneuraminate lyase, TRIETHYLENE GLYCOL | 著者 | Kumar, J.P, Rao, H, Nayak, V, Ramaswamy, S. | 登録日 | 2018-03-23 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum Acta Crystallogr F Struct Biol Commun, 74, 2018
|
|
2R9G
| Crystal structure of the C-terminal fragment of AAA ATPase from Enterococcus faecium | 分子名称: | AAA ATPase, central region, ACETATE ION, ... | 著者 | Ramagopal, U.A, Patskovsky, Y, Bonanno, J.B, Shi, W, Toro, R, Meyer, A.J, Rutter, M, Wu, B, Groshong, C, Gheyi, T, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2007-09-12 | 公開日 | 2007-10-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Crystal Structure of the C-Terminal Domain of AAA ATPase from Enterococcus faecium. To be Published
|
|
5ZKT
| |
5ZL1
| Hexameric structure of copper-containing nitrite reductase of an anammox organism KSU-1 | 分子名称: | CALCIUM ION, COPPER (II) ION, Putative copper-type nitrite reductase, ... | 著者 | Hira, D, Matsumura, M, Kitamura, R, Fujii, T. | 登録日 | 2018-03-26 | 公開日 | 2019-04-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Hexameric structure of copper-containing nitrite reductase of an anammox organism KSU-1 To Be Published
|
|
2RGO
| Structure of Alpha-Glycerophosphate Oxidase from Streptococcus sp.: A Template for the Mitochondrial Alpha-Glycerophosphate Dehydrogenase | 分子名称: | Alpha-Glycerophosphate Oxidase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Colussi, T, Boles, W, Mallett, T.C, Karplus, P.A, Claiborne, A. | 登録日 | 2007-10-04 | 公開日 | 2008-01-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase. Biochemistry, 47, 2008
|
|
2RKF
| HIV-1 PR resistant mutant + LPV | 分子名称: | GLYCEROL, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, PROTEASE RETROPEPSIN, ... | 著者 | Rezacova, P, Brynda, J, Kozisek, M, Saskova, K.G, Konvalinka, J. | 登録日 | 2007-10-16 | 公開日 | 2008-08-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region J.Virol., 82, 2008
|
|