PDB: 1555 件ウェブページステータス検索Chemie searchBIRD

---

6YO2	Meta-Carborane propyl-sulfonamide in complex with CA IX mimic 分子名称: Carbonic anhydrase 2, Meta-Carborane propyl-sulfonamide, ZINC ION 著者 Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. 登録日 2020-04-14 公開日 2020-08-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Direct Introduction of an Alkylsulfonamido Group on C-sites of Isomeric Dicarba-closo-dodecaboranes: The Influence of Stereochemistry on Inhibitory Activity against the Cancer-Associated Carbonic Anhydrase IX Isoenzyme. Chemistry, 26, 2020
6YO4	Para-Carborane propyl-sulfonamide in complex with CA IX mimic 分子名称: Carbonic anhydrase 2, Para-Carborane propyl-sulfonamide, ZINC ION 著者 Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. 登録日 2020-04-14 公開日 2020-08-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Direct Introduction of an Alkylsulfonamido Group on C-sites of Isomeric Dicarba-closo-dodecaboranes: The Influence of Stereochemistry on Inhibitory Activity against the Cancer-Associated Carbonic Anhydrase IX Isoenzyme. Chemistry, 26, 2020
6YOK	Para-Carborane di-propyl-sulfonamide in complex with CA IX mimic 分子名称: Carbonic anhydrase 2, Para-Carborane di-propyl-sulfonamide, ZINC ION 著者 Kugler, M, Brynda, J, Pospisilova, K, Rezacova, P. 登録日 2020-04-14 公開日 2020-08-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Direct Introduction of an Alkylsulfonamido Group on C-sites of Isomeric Dicarba-closo-dodecaboranes: The Influence of Stereochemistry on Inhibitory Activity against the Cancer-Associated Carbonic Anhydrase IX Isoenzyme. Chemistry, 26, 2020
6YJ3	Metala-Carborane di-propyl-sulfonamide 分子名称: Carbonic anhydrase 2, Metala-Carborane di-propyl-sulfonamide, ZINC ION 著者 Brynda, J, Rezacova, P, Pospisilova, K, Kugler, M. 登録日 2020-04-02 公開日 2020-09-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX. Chempluschem, 86, 2021
3KWD	Inactive truncation of the beta-carboxysomal gamma-Carbonic Anhydrase, CcmM, form 1 分子名称: CHLORIDE ION, Carbon dioxide concentrating mechanism protein, ZINC ION 著者 Pena, K.L, Kimber, M.S, Castel, S.E. 登録日 2009-12-01 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Structural basis of the oxidative activation of the carboxysomal {gamma}-carbonic anhydrase, CcmM. Proc.Natl.Acad.Sci.USA, 107, 2010
3KWC	Oxidized, active structure of the beta-carboxysomal gamma-Carbonic Anhydrase, CcmM 分子名称: CHLORIDE ION, Carbon dioxide concentrating mechanism protein, ISOPROPYL ALCOHOL, ... 著者 Kimber, M.S, Castel, S.E, Pena, K.L. 登録日 2009-12-01 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis of the oxidative activation of the carboxysomal {gamma}-carbonic anhydrase, CcmM. Proc.Natl.Acad.Sci.USA, 107, 2010
3KWE	Inactive truncation of the beta-carboxysomal gamma-Carbonic Anhydrase, CcmM, form 2 分子名称: CHLORIDE ION, Carbon dioxide concentrating mechanism protein, HEXANE-1,6-DIOL, ... 著者 Kimber, M.S, Castel, S.E, Pena, K.L. 登録日 2009-12-01 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Structural basis of the oxidative activation of the carboxysomal {gamma}-carbonic anhydrase, CcmM. Proc.Natl.Acad.Sci.USA, 107, 2010
3M1Q	Carbonic Anhydrase II mutant W5C-H64C with opened disulfide bond 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Schulze Wischeler, J, Heine, A, Klebe, G. 登録日 2010-03-05 公開日 2011-05-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Mutational study on Carbonic Anhydrase II To be Published
3MZC	Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor 分子名称: 4-[(cyclopentylcarbamoyl)amino]benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Avvaru, B.S, Wagner, J, Robbins, A.H, Mckenna, R. 登録日 2010-05-12 公開日 2011-03-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.498 Å) 主引用文献 Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency. Chem.Commun.(Camb.), 46, 2010
3ML2	Human carbonic anhydsase II in complex with an aryl sulfonamide inhibitor 分子名称: 2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Avvaru, B.S, Wagner, J, Robbins, A.H, Mckenna, R. 登録日 2010-04-16 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations. Bioorg.Med.Chem., 18, 2010
1DMX	MURINE MITOCHONDRIAL CARBONIC ANYHDRASE V AT 2.45 ANGSTROMS RESOLUTION 分子名称: MURINE CARBONIC ANHYDRASE V, ZINC ION 著者 Boriack-Sjodin, P.A, Christianson, D.W. 登録日 1995-10-04 公開日 1996-04-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design. Proc.Natl.Acad.Sci.USA, 92, 1995
1DMY	COMPLEX BETWEEN MURINE MITOCHONDRIAL CARBONIC ANYHDRASE V AND THE TRANSITION STATE ANALOGUE ACETAZOLAMIDE 分子名称: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, MURINE CARBONIC ANHYDRASE V, ZINC ION 著者 Boriack-Sjodin, P.A, Christianson, D.W. 登録日 1995-10-04 公開日 1996-04-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design. Proc.Natl.Acad.Sci.USA, 92, 1995
3V3J	Kinetic and structural studies of thermostabilized mutants of HCA II. 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Boone, C.D, Fisher, S.Z, McKenna, R. 登録日 2011-12-13 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II. Protein Eng.Des.Sel., 25, 2012
3U7C	crystal structure of the V143I mutant of human carbonic anhydrase II 分子名称: BICARBONATE ION, CARBON DIOXIDE, Carbonic anhydrase 2, ... 著者 West, D.M, Kim, C.U, Robbins, A.H, Mckenna, R. 登録日 2011-10-13 公開日 2013-02-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (0.93 Å) 主引用文献 crystal structure of the V143I mutant of human carbonic anhydrase II To be Published
1MUA	STRUCTURE AND ENERGETICS OF A NON-PROLINE CIS-PEPTIDYL LINKAGE IN AN ENGINEERED PROTEIN 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Nair, S.K, Christianson, D.W. 登録日 1993-06-18 公開日 1993-10-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant. Biochemistry, 32, 1993
4GL1	Structure of H64A/N62L/N67L Human Carbonic Anhydrase II triple mutant 分子名称: Carbonic anhydrase 2, ZINC ION 著者 West, D.M. 登録日 2012-08-13 公開日 2013-09-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Hydrophobicity and low pKa impact catalytic efficiency of Human Carbonic Anhydrases To be Published
2WEJ	Thermodynamic Optimisation of Carbonic Anhydrase Fragment Inhibitors 分子名称: CARBONIC ANHYDRASE 2, GLYCEROL, ZINC ION, ... 著者 Scott, A.D, Phillips, C, Alex, A, Bent, A, O'Brien, R, Damian, L, Jones, L.H. 登録日 2009-03-31 公開日 2009-11-10 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Thermodynamic Optimisation in Drug Discovery: A Case Study Using Carbonic Anhydrase Inhibitors. Chemmedchem, 4, 2009
7U5W	Crystal Structure Analysis of human Carbonic anhydrase 2 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2022-03-02 公開日 2023-03-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Crystal Structure Analysis of human Carbonic anhydrase 2 To Be Published
7U5X	Crystal Structure Analysis of human Carbonic anhydrase 2 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Seo, H.-S, Dhe-Paganon, S. 登録日 2022-03-02 公開日 2023-03-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.04 Å) 主引用文献 Crystal Structure Analysis of human Carbonic anhydrase 2 To Be Published
6LAC	The structural basis of the beta-carbonic anhydrase CafD (C39A mutant) of the filamentous fungus Aspergillus fumigatus 分子名称: Carbonic anhydrase, ZINC ION 著者 Jiin, M.S, Kim, S, Kim, N.J, Hong, S, Kim, S, Sung, J. 登録日 2019-11-12 公開日 2019-11-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The structural analysis of non-catalytic zinc binding site in the minor beta-carbonic anhydrase CafD To be published
3ZP9	Human Carbonic Anhydrase II as a Scaffold for an Artificial Transfer Hydrogenase 分子名称: CARBONIC ANHYDRASE 2, GLYCEROL, MERCURIBENZOIC ACID, ... 著者 Heinisch, T, Schirmer, T. 登録日 2013-02-27 公開日 2013-10-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Human Carbonic Anhydrase II as Host Protein for the Creation of Artificial Metalloenzymes: The Asymmetric Transfer Hydrogenation of Imines Chem.Sci., 4, 2013
6UZU	Carbonic Anhydrase IX-mimic In Complex WITH U-CH3 分子名称: 4-{[(3,5-dimethylphenyl)carbamoyl]amino}benzene-1-sulfonamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 McKenna, R, Mboge, M.Y, Mahon, B.P. 登録日 2019-11-15 公開日 2020-10-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides. Eur J Med Chem, 132, 2017
3M1J	The crystal structure of a NAMI A-Carbonic Anhydrase II adduct discloses the mode of action of this novel anticancer metallodrug 分子名称: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, IMIDAZOLE, ... 著者 Temperini, C, Messori, L. 登録日 2010-03-05 公開日 2011-01-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins Chemmedchem, 5, 2010
3M14	Carbonic Anhydrase II in complex with novel sulfonamide inhibitor 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, N-[(2Z)-1,3-thiazolidin-2-ylidene]sulfamide, ... 著者 Schulze Wischeler, J, Heine, A, Klebe, G, Sandner, N.U. 登録日 2010-03-04 公開日 2011-05-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Structural investigation and inhibitor studies on Carbonic Anhydrase II To be Published
3M04	Carbonic Anhydrase II in complex with novel sulfonamide inhibitor 分子名称: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, ZINC ION, ... 著者 Schulze Wischeler, J, Heine, A, Klebe, G, Sandner, N.U. 登録日 2010-03-02 公開日 2011-05-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural investigation and inhibitor studies on Carbonic Anhydrase II To be Published

<35363738394041424344454647484950>