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6YJ3

Metala-Carborane di-propyl-sulfonamide

Summary for 6YJ3
Entry DOI10.2210/pdb6yj3/pdb
DescriptorCarbonic anhydrase 2, ZINC ION, Metala-Carborane di-propyl-sulfonamide, ... (4 entities in total)
Functional Keywordscarbonic anhydrase ix, ca inhibitor, lyase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight30423.52
Authors
Brynda, J.,Rezacova, P.,Pospisilova, K.,Kugler, M. (deposition date: 2020-04-02, release date: 2020-09-09, Last modification date: 2024-01-24)
Primary citationGruner, B.,Kugler, M.,El Anwar, S.,Holub, J.,Nekvinda, J.,Bavol, D.,Ruzickova, Z.,Pospisilova, K.,Fabry, M.,Kral, V.,Brynda, J.,Rezacova, P.
Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX.
Chempluschem, 86:352-363, 2021
Cited by
PubMed Abstract: Carbonic anhydrase IX (CAIX) is an enzyme expressed on the surface of cells in hypoxic tumors. It plays a role in regulation of tumor pH and promotes thus tumor cell survival and occurrence of metastases. Here, derivatives of the cobalt bis(dicarbollide)(1-) anion are reported that are based on substitution at the carbon sites of the polyhedra by two alkylsulfonamide groups differing in the length of the aliphatic connector (from C1 to C4, n=1-4), which were prepared by cobalt insertion into the 7-sulfonamidoalkyl-7,8-dicarba-nido-undecaborate ions. Pure meso- and rac-diastereoisomeric forms were isolated. The series is complemented with monosubstituted species (n=2). Synthesis by a direct method furnished similar derivatives (n=2, 3), which are chlorinated at the B(8,8') boron sites. All compounds inhibited CAIX with subnanomolar inhibition constants and showed high selectivity for CAIX. The best inhibitory properties were observed for the compound with n= 3 and two substituents present in rac-arrangement with K =20 pM and a selectivity index of 668. X-ray crystallography was used to study interactions of these compounds with the active site of CAIX on the structural level.
PubMed: 32955786
DOI: 10.1002/cplu.202000574
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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