PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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5WHB	KRas G12V, bound to GDP and miniprotein 225-11(A30R) 分子名称: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. 登録日 2017-07-16 公開日 2018-01-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Exceptionally high-affinity Ras binders that remodel its effector domain. J. Biol. Chem., 293, 2018
5WQD	Crystal structure of TRF2 TRFH in complex with an NBS1 peptide 分子名称: Nibrin, Telomeric repeat-binding factor 2 著者 Hu, C, Chen, Y, Lei, M. 登録日 2016-11-26 公開日 2017-03-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres Mol. Cell, 65, 2017
5WU6	Crystal structure of apo human Tut1, form IV 分子名称: MAGNESIUM ION, Speckle targeted PIP5K1A-regulated poly(A) polymerase 著者 Yamashita, S, Tomita, K. 登録日 2016-12-16 公開日 2017-05-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.209 Å) 主引用文献 Crystal structures of U6 snRNA-specific terminal uridylyltransferase Nat Commun, 8, 2017
4NKA	Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 2 分子名称: 1,2-ETHANEDIOL, Fibroblast growth factor receptor 1, N~4~-{3-[2-(3,4-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine, ... 著者 Norman, R.A, Klein, T. 登録日 2013-11-12 公開日 2013-12-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures. ACS Med Chem Lett, 5, 2014
5CQ7	Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with N,N-dimethylquinoxaline-6-carboxamide (SGC - Diamond I04-1 fragment screening) 分子名称: 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B, N,N-dimethylquinoxaline-6-carboxamide 著者 Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2015-07-21 公開日 2015-09-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with N,N-dimethylquinoxaline-6-carboxamide (SGC - Diamond I04-1 fragment screening) To be published
5WIX	Crystal structure of P47 of Clostridium botulinum E1 分子名称: p-47 protein 著者 Lam, K, Liu, S, Qi, R, Jin, R. 登録日 2017-07-20 公開日 2017-10-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein. Toxicon, 147, 2018
6CCT	Fragment of GID4 in complex with a short peptide 分子名称: Glucose-induced degradation protein 4 homolog, Tetrapeptide 著者 Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2018-02-07 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nat. Chem. Biol., 14, 2018
5WUN	Crystal structure of mouse importin-alpha1 bound to non-phosphorylated NLS of EBNA1 分子名称: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1 著者 Nakada, R, Hirano, H, Matsuura, Y. 登録日 2016-12-19 公開日 2017-01-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal. Biochem. Biophys. Res. Commun., 484, 2017
4JMI	Sec7 domain of ARNO, an exchange factor, at 1.5 Angstrom resolution 分子名称: Cytohesin-2 著者 Hoh, F, Rouhana, J. 登録日 2013-03-14 公開日 2013-10-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors J.Med.Chem., 56, 2013
5X1D	Crystal Structure of T246A-N247A Human CRMP-2 Mutant 分子名称: Dihydropyrimidinase-related protein 2 著者 Nitta, R, Tomabechi, Y, Aoki, M, Shirouzu, M. 登録日 2017-01-25 公開日 2017-09-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for CRMP2-induced axonal microtubule formation Sci Rep, 7, 2017
6FUV	Structure of a manno-oligosaccharide specific solute binding protein, BlMnBP2 from Bifidobacterium animalis subsp. lactis ATCC 27673 in complex with mannotriose 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ACETATE ION, Solute Binding Protein, ... 著者 Ejby, M, Abou Hachem, M, Guskov, A, Slotboom, D.J. 登録日 2018-02-27 公開日 2019-03-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on beta-mannan possess distinct manno-oligosaccharide-binding profiles. Mol.Microbiol., 112, 2019
5WPN	Zn-bound Structure of Chaetopterus variopedatus Ferritin 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... 著者 De Meulenaere, E, Bailey, J.B, Tezcan, F.A, Deheyn, D. 登録日 2017-08-05 公開日 2017-12-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 First biochemical and crystallographic characterization of a fast-performing ferritin from a marine invertebrate. Biochem. J., 474, 2017
4MFV	Crystal structure of human CTNNBL1(residues 33~563) 分子名称: Beta-catenin-like protein 1 著者 Ahn, J.W, Kim, S, Kim, K.J. 登録日 2013-08-28 公開日 2014-03-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex Acta Crystallogr.,Sect.D, 70, 2014
5WUM	Crystal structure of mouse importin-alpha1 bound to S385-phosphorylated NLS of EBNA1 分子名称: Epstein-Barr nuclear antigen 1, Importin subunit alpha-1 著者 Nakada, R, Hirano, H, Matsuura, Y. 登録日 2016-12-19 公開日 2017-01-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal. Biochem. Biophys. Res. Commun., 484, 2017
5WAC	ADC-7 in complex with boronic acid transition state inhibitor CR157 分子名称: Beta-lactamase, phosphonooxy-[[[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]sulfonylamino]methyl]borinic acid 著者 Powers, R.A, Wallar, B.J. 登録日 2017-06-26 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.061 Å) 主引用文献 Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase. ACS Infect Dis, 4, 2018
5WAG	ADC-7 in complex with boronic acid transition state inhibitor S06017 分子名称: 1-{[hydroxy(phosphonooxy)boranyl]methyl}-1H-1,2,3-triazole-4-carboxylic acid, Beta-lactamase, SUCCINIC ACID 著者 Powers, R.A, Wallar, B.J. 登録日 2017-06-26 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.931 Å) 主引用文献 Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase. ACS Infect Dis, 4, 2018
5CU8	Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 2-Amino-6-chlorobenzothiazole (SGC - Diamond I04-1 fragment screening) 分子名称: 1,2-ETHANEDIOL, 6-chloro-1,3-benzothiazol-2-amine, Bromodomain adjacent to zinc finger domain protein 2B 著者 Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2015-07-24 公開日 2015-09-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 2-Amino-6-chlorobenzothiazole (SGC - Diamond I04-1 fragment screening) To be published
5WBY	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5CUE	Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with AGN-PC-04G0SS (SGC - Diamond I04-1 fragment screening) 分子名称: 1,2-ETHANEDIOL, 5-chloro-N,1-dimethyl-1H-pyrazole-4-carboxamide, Bromodomain adjacent to zinc finger domain protein 2B 著者 Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2015-07-24 公開日 2015-09-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with AGN-PC-04G0SS (SGC - Diamond I04-1 fragment screening) To be published
5WDH	Motor domain of human kinesin family member C1 分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIFC1, MAGNESIUM ION, ... 著者 Zhu, H, Tempel, W, He, H, Shen, Y, Wang, J, Brothers, G, Landry, R, Arrowsmith, C.H, Edwards, A.M, Park, H, Structural Genomics Consortium (SGC) 登録日 2017-07-05 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.248 Å) 主引用文献 Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein. Sci Rep, 7, 2017
5WY9	Apo form crystal structure of human Lipocalin PGDS . 分子名称: 2-(2-METHOXYETHOXY)ETHANOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Prostaglandin-H2 D-isomerase 著者 Saif, M, Pervushin, K. 登録日 2017-01-11 公開日 2017-01-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 To be published To Be Published
5WZN	Alpha-N-acetylgalactosaminidase NagBb from Bifidobacterium bifidum - GalNAc complex 分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, Alpha-N-acetylgalactosaminidase, CALCIUM ION, ... 著者 Sato, M, Arakawa, T, Ashida, H, Fushinobu, S. 登録日 2017-01-18 公開日 2017-06-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors J. Biol. Chem., 292, 2017
6G4Q	Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2 分子名称: 1,2-ETHANEDIOL, Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, ... 著者 Bailey, H.J, Shrestha, L, Rembeza, E, Sorrell, F.J, Newman, J, Strain-Damerell, C, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W. 登録日 2018-03-28 公開日 2018-04-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2 To Be Published
5X0R	Crystal Structure of PXR LBD Complexed with SJB7 分子名称: 4-[(4-tert-butylphenyl)sulfonyl]-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2 著者 Lv, L, Lin, W, Chai, S.C, Zhang, Q, Chen, T. 登録日 2017-01-23 公開日 2017-10-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.665 Å) 主引用文献 SPA70 is a potent antagonist of human pregnane X receptor. Nat Commun, 8, 2017
4JXF	Crystal Structure of PLK4 Kinase with an inhibitor: 400631 ((1R,2S)-2-{3-[(E)-2-{4-[(DIMETHYLAMINO)METHYL]PHENYL}ETHENYL]-2H-INDAZOL-6-YL}-5'-METHOXYSPIRO[CYCLOPROPANE-1,3'-INDOL]-2'(1'H)-ONE) 分子名称: (1R,2S)-2-{3-[(E)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one, 1,2-ETHANEDIOL, Serine/threonine-protein kinase PLK4 著者 Qiu, W, Plotnikova, O, Feher, M, Awrey, D.E, Chirgadze, N.Y. 登録日 2013-03-28 公開日 2014-04-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of PLK4 Kinase with an inhibitor: 400631 To be Published

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