PDB: 2596 件ウェブページステータス検索Chemie searchBIRD

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4NZL	Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases 分子名称: Neutrophil elastase, Uncharacterized protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Stapels, D.A.C, von Koeckritz-Blickwede, M, Ramyar, K.X, Bischoff, M, Milder, F, Ruyken, M, Scheepmaker, L, McWhorter, W.J, Herrmann, M, van Kessel, K.P.M, Geisbrecht, B.V, Rooijakkers, S.H.M. 登録日 2013-12-12 公開日 2014-08-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014
8ENI	Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor 分子名称: 3-[4-(5-fluoro-4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)butyl]-5-methyl-1,3-benzoxazol-2(3H)-one, Bifunctional ligase/repressor BirA 著者 Wilce, M.C.J, Cini, D.A. 登録日 2022-09-30 公開日 2022-11-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus. ACS Infect Dis, 4, 2018
7LV0	Pre-translocation rotated ribosome +1-frameshifting(CCC-A) complex (Structure Irot-FS) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Demo, G, Loveland, A.B, Svidritskiy, E, Gamper, H.B, Hou, Y.M, Korostelev, A.A. 登録日 2021-02-23 公開日 2021-07-28 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Nat Commun, 12, 2021
7R5A	Vibrio cholera ParD2:ParE2 antitoxin:toxin complex 分子名称: Antitoxin ParD, Toxin 著者 Garcia-Rodriguez, G, Loris, R. 登録日 2022-02-10 公開日 2022-04-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Toxin:antitoxin ratio sensing autoregulation of the Vibrio cholerae parDE2 module. Sci Adv, 10, 2024
4ABZ	TetR(D) in Complex with Tigecycline and Magnesium, co-crystallized 分子名称: CHLORIDE ION, MAGNESIUM ION, TIGECYCLINE, ... 著者 Volkers, G, Hinrichs, W. 登録日 2011-12-12 公開日 2012-12-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.886 Å) 主引用文献 TetR(D) in Complex with Tigecycline and Magnesium To be Published
7EBK	Mouse Trim66 PHD-Bromo dual domain complexed with the H3(1-24)K9me3K18ac peptide 分子名称: H3K9me3K18ac, Tripartite motif-containing protein 66, ZINC ION 著者 Wang, Z, Jiang, J. 登録日 2021-03-09 公開日 2022-03-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells. Cell Stem Cell, 29, 2022
7EBJ	Apo structure of the mouse Trim66 PHD-Bromo dual domain 分子名称: Tripartite motif-containing protein 66, ZINC ION 著者 Wang, Z, Jiang, J. 登録日 2021-03-09 公開日 2022-03-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells. Cell Stem Cell, 29, 2022
8G24	Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 5.5 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin-G, MAP domain-containing protein, ... 著者 Mishra, N.B, Geisbrecht, B.V. 登録日 2023-02-03 公開日 2023-04-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299, 2023
8G25	Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 7.5 分子名称: Cathepsin-G, MAP domain-containing protein, Neutrophil elastase 著者 Mishra, N.B, Geisbrecht, B.V. 登録日 2023-02-03 公開日 2023-04-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299, 2023
8G26	Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 8.5 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin-G, ... 著者 Mishra, N.B, Geisbrecht, B.V. 登録日 2023-02-03 公開日 2023-04-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299, 2023
7T5U	Structure of E. coli MS115-1 CapH N-terminal domain 分子名称: Helix-turn-helix domain-containing protein, SULFATE ION 著者 Lau, R.K, Corbett, K.D. 登録日 2021-12-13 公開日 2022-09-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.02 Å) 主引用文献 A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage. Embo J., 41, 2022
7T5V	Structure of E. coli CapH C-terminal domain I99M mutant 分子名称: Helix-turn-helix domain-containing protein 著者 Lau, R.K, Corbett, K.D. 登録日 2021-12-13 公開日 2022-09-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage. Embo J., 41, 2022
7T5W	Structure of E. coli CapH C-terminal domain 分子名称: Helix-turn-helix domain-containing protein 著者 Lau, R.K, Corbett, K.D. 登録日 2021-12-13 公開日 2022-09-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage. Embo J., 41, 2022
7M10	PHF2 PHD Domain Complexed with Peptide From N-terminus of VRK1 分子名称: FORMIC ACID, Lysine-specific demethylase PHF2, Serine/threonine-protein kinase VRK1 N-terminus peptide, ... 著者 Horton, J.R, Cheng, X. 登録日 2021-03-11 公開日 2021-05-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. Biochem.J., 478, 2021
5LOE	Structure of full length Cody from Bacillus subtilis in complex with Ile 分子名称: GTP-sensing transcriptional pleiotropic repressor CodY, ISOLEUCINE 著者 Wilkinson, A.J, Levdikov, V.M, Blagova, E.V. 登録日 2016-08-09 公開日 2017-01-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis. J. Biol. Chem., 292, 2017
5LOJ	Structure of full length unliganded CodY from Bacillus subtilis 分子名称: GTP-sensing transcriptional pleiotropic repressor CodY 著者 Wilkinson, A.J, Levdikov, V.M, Blagova, E.V. 登録日 2016-08-09 公開日 2017-01-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.71 Å) 主引用文献 Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis. J. Biol. Chem., 292, 2017
5LNH	Structure of full length Unliganded CodY from Bacillus subtilis 分子名称: GTP-sensing transcriptional pleiotropic repressor CodY, SULFATE ION 著者 Wilkinson, A.J, Levdikov, V.M, Blagova, E.V. 登録日 2016-08-04 公開日 2017-01-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis. J. Biol. Chem., 292, 2017
5LOO	Structure of full length unliganded CodY from Bacillus subtilis 分子名称: GTP-sensing transcriptional pleiotropic repressor CodY 著者 Wilkinson, A.J, Levdikov, V.M, Blagova, E.V. 登録日 2016-08-09 公開日 2017-01-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis. J. Biol. Chem., 292, 2017
6PF4	Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase, [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)phenyl]acetic acid 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.854 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
7JSA	Crystal structure of the DNA binding domain of human transcription factor ERF in the reduced form, in complex with double-stranded DNA ACCGGAAGTG 分子名称: DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ETS domain-containing transcription factor ERF 著者 Hou, C, Tsodikov, O.V. 登録日 2020-08-14 公開日 2020-11-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural Insight into the DNA Binding Function of Transcription Factor ERF. Biochemistry, 2020
6PF3	Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-chlorobenzoic acid 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-chlorobenzoic acid, Thymidylate synthase 著者 Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. 登録日 2019-06-21 公開日 2019-10-02 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.391 Å) 主引用文献 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
7JSL	Crystal structure of the DNA binding domain of human transcription factor ERF in the oxidized form, in complex with double-stranded DNA ACCGGAAGTG 分子名称: DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ETS domain-containing transcription factor ERF 著者 Hou, C, Tsodikov, O.V. 登録日 2020-08-14 公開日 2020-11-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (4.51 Å) 主引用文献 Structural Insight into the DNA Binding Function of Transcription Factor ERF. Biochemistry, 2020
6SMA	Crystal structure of Human Neutrophil Elastase (HNE) in complex with the 3-Oxo-beta-Sultam inhibitor LMC249 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[[1-[(4-bromophenyl)methyl]-1,2,3-triazol-4-yl]methylcarbamoyl]pentane-3-sulfonic acid, ... 著者 Brito, J.A, Almeida, V.T, Carvalho, L.M, Moreira, R, Archer, M. 登録日 2019-08-21 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 3-Oxo-beta-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling. Acs Chem.Biol., 15, 2020
4YZ6	Crystal Structure of Myc3[44-238] from Arabidopsis in complex with Jaz1 peptide [200-221] 分子名称: Protein TIFY 10A, Transcription factor MYC3 著者 Ke, J, Zhang, F, Brunzelle, J, Xu, H.E, Melcher, K, HE, S.Y. 登録日 2015-03-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling. Nature, 525, 2015
7AG1	Crystal structure of E. coli SFP aldolase (YihT) from sulfo-EMP pathway 分子名称: 1,2-ETHANEDIOL, Sulfofructosephosphate aldolase 著者 Sharma, M, Davies, G.J, Jin, Y. 登録日 2020-09-21 公開日 2021-04-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis. Acs Cent.Sci., 7, 2021

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