9EZX
| Vibrio cholerae DdmD apo complex | 分子名称: | Helicase/UvrB N-terminal domain-containing protein | 著者 | Loeff, L, Jinek, M. | 登録日 | 2024-04-14 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Molecular mechanism of plasmid elimination by the DdmDE defense system. Science, 385, 2024
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9EZJ
| Apo human TDO in complex with a bound inhibitor (Cpd-4) | 分子名称: | Tryptophan 2,3-dioxygenase, alpha-methyl-L-tryptophan, ethyl (9~{R})-2-methoxy-4-oxidanylidene-9-[[(1~{S})-1-phenylethyl]-[(2-propan-2-ylphenyl)carbamoyl]amino]-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidine-3-carboxylate | 著者 | Wicki, M, Mac Sweeney, A. | 登録日 | 2024-04-12 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.612 Å) | 主引用文献 | Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2 To Be Published
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9EZ8
| Cryo-EM structure of the icosahedral lumazine synthase from Vicia faba. | 分子名称: | 6,7-dimethyl-8-ribityllumazine synthase | 著者 | Chee, M, Trapani, S, Hoh, F, Lai Kee Him, J, Yvon, M, Blanc, S, Bron, P. | 登録日 | 2024-04-11 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Cryo-EM structure of the icosahedral lumazine synthase from Vicia faba. To Be Published
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9EYR
| VDR complex with gemini analog UG-480 | 分子名称: | (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{R})-5-methyl-1-[(1~{S},2~{S})-2-(3-methyl-3-oxidanyl-butyl)cyclopropyl]-5-oxidanyl-hexyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | 著者 | Rochel, N. | 登録日 | 2024-04-09 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of New Type of Gemini Analogues with a Cyclopropane Moiety in Their Side Chain. J.Med.Chem., 67, 2024
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9EY8
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9EY7
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9EY6
| Crystal structure of human tyrosinase-related protein 1 (TYRP1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 5,6-dihydroxyindole-2-carboxylic acid oxidase, ... | 著者 | Ng, Y.M, Soler-Lopez, M. | 登録日 | 2024-04-09 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.228 Å) | 主引用文献 | Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies. Chembiochem, 25, 2024
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9EY5
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9EVM
| High pH (8.0) nitrite-bound MSOX movie series dataset 30 of the copper nitrite reductase (NirK) from Bradyrhizobium japonicum USDA110 [20.7 MGy] | 分子名称: | COPPER (II) ION, Copper-containing nitrite reductase, NITRITE ION, ... | 著者 | Rose, S.L, Ferroni, F.M, Horrell, S, Brondino, C.D, Eady, R.R, Jaho, S, Hough, M.A, Owen, A.L, Antonyuk, S.V, Hasnain, S.S. | 登録日 | 2024-03-30 | 公開日 | 2024-07-24 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Spectroscopically Validated pH-dependent MSOX Movies Provide Detailed Mechanism of Copper Nitrite Reductases. J.Mol.Biol., 436, 2024
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9EV4
| Pyruvate:quinone oxidoreductase (PQO) from Corynebacterium glutamicum CS176 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (Cytochrome), ... | 著者 | Da Silva Lameira, C, Muenssinger, S, Yang, L, Eikmanns, B.J, Bellinzoni, M. | 登録日 | 2024-03-28 | 公開日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.474 Å) | 主引用文献 | Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features. Febs J., 2024
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9EUS
| Mpro from SARS-CoV-2 with R298A mutation | 分子名称: | GLYCEROL, Replicase polyprotein 1a | 著者 | Plewka, J, Lis, K, Czarna, A, Pyrc, K, Kantyka, T, Chykunova, Y. | 登録日 | 2024-03-28 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | SARS-CoV-2 M pro oligomerization as a potential target for therapy. Int.J.Biol.Macromol., 267, 2024
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9EUD
| The FK1 domain of FKBP51 in complex with SAFit-analog 23c | 分子名称: | (1-propan-2-ylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | 著者 | Meyners, C, Buffa, V, Hausch, F. | 登録日 | 2024-03-27 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.022 Å) | 主引用文献 | 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile. Chemmedchem, 2024
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9EU5
| SSX structure of Autotaxin at room temperature | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | 著者 | Eymery, M.C, McCarthy, A.A, Foos, N, Basu, S. | 登録日 | 2024-03-27 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry. Iucrj, 2024
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9EST
| STRUCTURAL STUDY OF PORCINE PANCREATIC ELASTASE COMPLEXED WITH 7-AMINO-3-(2-BROMOETHOXY)-4-CHLOROISOCOUMARIN AS A NONREACTIVATABLE DOUBLY COVALENT ENZYME-INHIBITOR COMPLEX | 分子名称: | (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE, CALCIUM ION, PORCINE PANCREATIC ELASTASE, ... | 著者 | Radhakrishnan, R, Powers, J.C, Meyer Jr, E.F. | 登録日 | 1991-01-14 | 公開日 | 1994-01-31 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex. Biochemistry, 30, 1991
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9ERO
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9ERN
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9ERM
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9EQK
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9EQH
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9EQF
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9EPL
| Mpro from SARS-CoV-2 with 298Q mutation | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Non-structural protein 11, ... | 著者 | Plewka, J, Lis, K, Czarna, A, Pyrc, K, Kantyka, T, Chykunova, Y. | 登録日 | 2024-03-18 | 公開日 | 2024-04-17 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | SARS-CoV-2 M pro oligomerization as a potential target for therapy. Int.J.Biol.Macromol., 267, 2024
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9EO8
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9EO5
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9EO2
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9ENZ
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