PDB: 493 件ウェブページステータス検索Chemie searchBIRD

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8P3N	Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK8 分子名称: 9-METHYL-9H-PURIN-6-AMINE, Chemotaxis protein CheA 著者 Adhav, A, Marina, A. 登録日 2023-05-18 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK8 To Be Published
6CJL	Candida albicans Hsp90 nucleotide binding domain in complex with radicicol 分子名称: Heat shock protein 90 homolog, MAGNESIUM ION, RADICICOL 著者 Nation, C, Pizarro, J.C. 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6972 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
8P59	Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-333 分子名称: 7-(2-phenylethoxy)quinazolin-2-amine, Chemotaxis protein CheA 著者 Adhav, A, Marina, A. 登録日 2023-05-23 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-333 To Be Published
8PF2	Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK16 分子名称: Chemotaxis protein CheA, RESORCINOL 著者 Adhav, A, Marina, A. 登録日 2023-06-15 公開日 2024-06-26 最終更新日 2024-08-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity. Microbiol Spectr, 12, 2024
2WEQ	Yeast Hsp90 N-terminal domain LI-IV mutant with Geldanamycin 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN, GLYCEROL 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2009-04-01 公開日 2009-04-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90 Acs Chem.Biol., 4, 2009
2WEP	Yeast Hsp90 N-terminal domain LI-IV mutant with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2009-04-01 公開日 2009-04-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90. Acs Chem.Biol., 4, 2009
6CJI	Candida albicans Hsp90 nucleotide binding domain 分子名称: 1,2-ETHANEDIOL, Heat shock protein 90 homolog 著者 Hutchinson, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, STRUCTURAL GENOMICS CONSORTIUM, S.G.C, Pizarro, J.C, Structural Genomics Consortium (SGC) 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
2XD6	Hsp90 complexed with a resorcylic acid macrolactone. 分子名称: (5Z)-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-3,4,7,8,9,10,11,12-OCTAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-6-CARBALDEHYDE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL 著者 Roe, S.M, Prodromou, C, Pearl, L.H, Moody, C.J. 登録日 2010-04-29 公開日 2010-08-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Inhibition of Hsp90 with Resorcylic Acid Macrolactones. Synthesis and Binding Studies. Chemistry, 16, 2010
6BLK	Mycobacterial sensor histidine kinase MprB 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Signal transduction histidine-protein kinase/phosphatase mprB 著者 Li, J, Korotkova, N, Korotkov, K.V. 登録日 2017-11-10 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.552 Å) 主引用文献 Mycobacterial sensor histidine kinase MprB to be published
8OYQ	Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK13 分子名称: Chemotaxis protein CheA, quinazolin-2-amine 著者 Adhav, A, Marina, A. 登録日 2023-05-05 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK13 To Be Published
8OZ9	Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-383 分子名称: 7-(1~{H}-1,2,3-triazol-5-yl)quinazolin-2-amine, Chemotaxis protein CheA 著者 Adhav, A, Marina, A. 登録日 2023-05-08 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound QUI-SV-383 To Be Published
8OYZ	Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK10 分子名称: 2-azanyl-7,8-dihydro-6~{H}-quinazolin-5-one, Chemotaxis protein CheA 著者 Adhav, A, Marina, A. 登録日 2023-05-05 公開日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK10 To Be Published
5IDM	Bifunctional histidine kinase CckA (domain, CA) in complex with c-di-GMP and AMPPNP/Mg2+ 分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Cell cycle histidine kinase CckA, MAGNESIUM ION, ... 著者 Dubey, B.N, Schirmer, T. 登録日 2016-02-24 公開日 2016-10-05 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Sci Adv, 2, 2016
2WER	Yeast Hsp90 N-terminal domain LI-IV mutant with Radicicol 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, RADICICOL 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2009-04-01 公開日 2009-04-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90. Acs Chem.Biol., 4, 2009
3U2K	S. aureus GyrB ATPase domain in complex with a small molecule inhibitor 分子名称: 2-chloro-6-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)pyridine-4-carboxamide, DNA gyrase subunit B, MAGNESIUM ION 著者 Boriack-Sjodin, P.A, Prince, D.B, Eakin, A.E, Sherer, B.A. 登録日 2011-10-03 公開日 2012-01-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents. Antimicrob.Agents Chemother., 56, 2012
2XX4	Macrolactone Inhibitor bound to HSP90 N-term 分子名称: (E)-ETHYL 13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDROBENZO[C][1]AZACYCLOTETRADECINE-10-CARBOXYLATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M. 登録日 2010-11-08 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.199 Å) 主引用文献 Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. Acs Chem.Biol., 6, 2011
2XX5	Macrolactone Inhibitor bound to HSP90 N-term 分子名称: (5E,10R)-N-BENZYL-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-1,2,3,4,7,8,9,10,11,12-DECAHYDRO-2-BENZAZACYCLOTETRADECINE-10-CARBOXAMIDE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL 著者 Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M. 登録日 2010-11-08 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. Acs Chem.Biol., 6, 2011
2YGA	E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2011-04-12 公開日 2011-11-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Features of the Streptomyces Hygroscopicus Htpg Reveal How Partial Geldanamycin Resistance Can Arise with Mutation to the ATP Binding Pocket of a Eukaryotic Hsp90. Faseb J., 25, 2011
6CJR	Candida albicans Hsp90 nucleotide binding domain in complex with SNX-2112 分子名称: 1,2-ETHANEDIOL, 4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide, Heat shock protein 90 homolog 著者 Kirkpatrick, M.G, Pizarro, J.C. 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
2XX2	Macrolactone Inhibitor bound to HSP90 N-term 分子名称: (5E)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-2-BENZAZACYCLOTETRADECINE-1,11(2H,12H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL 著者 Moody, C.J, Prodromou, C, Pearl, L.H, Roe, S.M. 登録日 2010-11-08 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies. Acs Chem.Biol., 6, 2011
3U2D	S. aureus GyrB ATPase domain in complex with small molecule inhibitor 分子名称: 4-bromo-5-methyl-N-[1-(3-nitropyridin-2-yl)piperidin-4-yl]-1H-pyrrole-2-carboxamide, DNA gyrase subunit B, MAGNESIUM ION 著者 Boriack-Sjodin, P.A, Prince, D.B, Eakin, A.E, Sherer, B.A. 登録日 2011-10-03 公開日 2012-01-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents. Antimicrob.Agents Chemother., 56, 2012
3U67	Crystal structure of the N-terminal domain of Hsp90 from Leishmania major(LmjF33.0312)in complex with ADP 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 83-1, ... 著者 Pizarro, J.C, Wernimont, A.K, Hutchinson, A, Mackenzie, F, Fairlamb, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Ferguson, M.A.J, Hui, R, Hills, T, Structural Genomics Consortium (SGC) 登録日 2011-10-12 公開日 2012-05-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PLoS Negl Trop Dis, 7, 2013
9MT9	Candida albicans Hsp90 nucleotide binding domain in complex with BTB10184 分子名称: 4-(4-hydroxyphenyl)sulfanylphenol, Heat shock protein 90 homolog 著者 Kowalewski, M.E, Redinbo, M.R. 登録日 2025-01-10 公開日 2025-06-04 最終更新日 2025-06-18 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural Insights into Selectively Targeting Candida albicans Hsp90. Biochemistry, 64, 2025
1I5C	STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHEMOTAXIS PROTEIN CHEA 著者 Bilwes, A.M, Quezada, C.M, Croal, L.R, Crane, B.R, Simon, M.I. 登録日 2001-02-26 公開日 2001-08-26 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Nucleotide binding by the histidine kinase CheA. Nat.Struct.Biol., 8, 2001
9MSV	Candida albicans Hsp90 nucleotide binding domain in complex with BEP800 分子名称: 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, Heat shock protein 90 homolog 著者 Kowalewski, M.E, Redinbo, M.R. 登録日 2025-01-10 公開日 2025-06-04 最終更新日 2025-06-18 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structural Insights into Selectively Targeting Candida albicans Hsp90. Biochemistry, 64, 2025

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