5CZT
 
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5DCB
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3STE
 | | Crystal structure of a mutant (Q202A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, SODIUM ION | | 著者 | Allison, T.M, Jameson, G.B, Gloyne, B.J, Parker, E.J. | | 登録日 | 2011-07-09 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase
Biochemistry, 50, 2011
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3SZ8
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1FX6
 | | AQUIFEX AEOLICUS KDO8P SYNTHASE | | 分子名称: | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATE ALDOLASE, PHOSPHATE ION | | 著者 | Duewel, H.S, Radaev, S, Wang, J, Woodard, R.W, Gatti, D.L. | | 登録日 | 2000-09-25 | | 公開日 | 2001-04-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Substrate and metal complexes of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Aquifex aeolicus at 1.9-A resolution. Implications for the condensation mechanism.
J.Biol.Chem., 276, 2001
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3UND
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3TMQ
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1OF6
 | | crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with tyrosine and manganese | | 分子名称: | D-TYROSINE, MANGANESE (II) ION, PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, ... | | 著者 | Koenig, V, Pfeil, A, Heinrich, G, Braus, G, Schneider, T.R. | | 登録日 | 2003-04-08 | | 公開日 | 2004-05-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of the Double Complex of the Tyrosine Sensitive Dahp Synthase from Yeast
To be Published
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4JTL
 | | Crystal structure of F139G mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION | | 著者 | Allison, T.M, Cochrane, F.C, Jameson, G.B, Parker, E.J. | | 登録日 | 2013-03-23 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Examining the Role of Intersubunit Contacts in Catalysis by 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthase.
Biochemistry, 52, 2013
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4HSO
 | | Crystal structure of S213G variant DAH7PS from Neisseria meningitidis | | 分子名称: | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... | | 著者 | Cross, P.J, Pietersma, A.L, Allison, T.M, Wilson-Coutts, S.M, Cochrane, F.C, Parker, E.J. | | 登録日 | 2012-10-30 | | 公開日 | 2013-09-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine.
Protein Sci., 22, 2013
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1LRN
 | | Aquifex aeolicus KDO8P synthase H185G mutant in complex with Cadmium | | 分子名称: | CADMIUM ION, KDO-8-phosphate synthetase, PHOSPHATE ION | | 著者 | Wang, J, Duewel, H.S, Stuckey, J.A, Woodard, R.W, Gatti, D.L. | | 登録日 | 2002-05-15 | | 公開日 | 2002-11-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Function of His185 in Aquifex aeolicus 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase
J.Mol.Biol., 324, 2002
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2NX3
 | | Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase | | 分子名称: | (2R,4R,5R,6R,7R)-2,4,5,6,7-PENTAHYDROXY-2,8-BIS(PHOSPHONOOXY)OCTANOIC ACID, 2-dehydro-3-deoxyphosphooctonate aldolase, ARABINOSE-5-PHOSPHATE, ... | | 著者 | Kona, F, Xu, X, Martin, P, Kuzmic, P, Gatti, D.L. | | 登録日 | 2006-11-16 | | 公開日 | 2007-04-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
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1OFP
 | | CRYSTAL STRUCTURE OF THE TYROSINE-REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE FROM SACCHAROMYCES CEREVISIAE | | 分子名称: | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE | | 著者 | Koenig, V, Pfeil, A, Heinrich, G, Braus, G.H, Schneider, T.R. | | 登録日 | 2003-04-17 | | 公開日 | 2004-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Substrate and Metal Complexes of 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase from Saccharomyces Cerevisiae Provide New Insights Into the Catalytic Mechanism
J.Mol.Biol., 337, 2004
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2NXH
 | | Structural and mechanistic changes along an engineered path from metallo to non-metallo KDO8P synthase. | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, PHOSPHATE ION, PHOSPHOENOLPYRUVATE | | 著者 | Kona, F, Xu, X, Martin, P, Kuzmic, P, Gatti, D.L. | | 登録日 | 2006-11-17 | | 公開日 | 2007-04-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Structural and Mechanistic Changes along an Engineered Path from Metallo to Nonmetallo 3-Deoxy-d-manno-octulosonate 8-Phosphate Synthases.
Biochemistry, 46, 2007
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5CKS
 | | DAHP (3-deoxy-D-arabinoheptulosonate-7-phosphate) Synthase in complex with DAHP Oxime. | | 分子名称: | DAHP Oxime, Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive, ... | | 著者 | Berti, P, Junop, M, Balachandran, N. | | 登録日 | 2015-07-15 | | 公開日 | 2016-08-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1181 Å) | | 主引用文献 | Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic.
Biochemistry, 55, 2016
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4C1K
 | | Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase | | 分子名称: | 2-DEHYDRO-3-DEOXYPHOSPHOHEPTONATE ALDOLASE, CADMIUM ION, CARBONATE ION, ... | | 著者 | Nazmi, A.R, Schofield, L.R, Dobson, R.C.J, Jameson, G.B, Parker, E.J. | | 登録日 | 2013-08-13 | | 公開日 | 2013-11-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Destabilization of the Homotetrameric Assembly of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase from the Hyperthermophile Pyrococcus Furiosus Enhances Enzymatic Activity
J.Mol.Biol., 426, 2014
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4UMB
 | | Structural analysis of substrate-mimicking inhibitors in complex with Neisseria meningitidis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water | | 分子名称: | (2R)-2-(phosphonooxy)propanoic acid, MANGANESE (II) ION, PHOSPHATE ION, ... | | 著者 | Heyes, L.C, Reichau, S, Cross, P.J, Parker, E.J. | | 登録日 | 2014-05-16 | | 公開日 | 2014-10-08 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Structural Analysis of Substrate-Mimicking Inhibitors in Complex with Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase - the Importance of Accommodating the Active Site Water.
Bioorg.Chem., 57, 2014
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4UC5
 | | Neisseria Meningitidis DAH7PS-Phenylalanine regulated | | 分子名称: | DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, PHENYLALANINE, ... | | 著者 | Heyes, L.C, Lang, E.J.M, Parker, E.J. | | 登録日 | 2014-12-03 | | 公開日 | 2015-11-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Calculated Pka Variations Expose Dynamic Allosteric Communication Networks.
J.Am.Chem.Soc., 138, 2016
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1RZM
 | | Crystal structure of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) from Thermotoga maritima complexed with Cd2+, PEP and E4P | | 分子名称: | CADMIUM ION, ERYTHOSE-4-PHOSPHATE, PHOSPHOENOLPYRUVATE, ... | | 著者 | Shumilin, I.A, Bauerle, R, Wu, J, Woodard, R.W, Kretsinger, R.H. | | 登録日 | 2003-12-24 | | 公開日 | 2004-08-10 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structure of the Reaction Complex of 3-Deoxy-d-arabino-heptulosonate-7-phosphate Synthase from Thermotoga maritima Refines the Catalytic Mechanism and Indicates a New Mechanism of Allosteric Regulation.
J.Mol.Biol., 341, 2004
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6BNG
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3STG
 | | Crystal structure of A58P, DEL(N59), and loop 7 truncated mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION | | 著者 | Allison, T.M, Jameson, G.B, Parker, E.J. | | 登録日 | 2011-07-09 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | An Extended (beta)7(alpha)7 Substrate-Binding Loop Is Essential for Efficient Catalysis by 3-Deoxy-D-manno-Octulosonate 8-Phosphate Synthase
Biochemistry, 50, 2011
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5DCE
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1ZJI
 | | Aquifex aeolicus KDO8PS R106G mutant in complex with 2PGA and R5P | | 分子名称: | 2-PHOSPHOGLYCERIC ACID, 2-dehydro-3-deoxyphosphooctonate aldolase, CADMIUM ION, ... | | 著者 | Xu, X, Kona, F, Wang, J, Lu, J, Stemmler, T, Gatti, D.L. | | 登録日 | 2005-04-28 | | 公開日 | 2005-09-27 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The Catalytic and Conformational Cycle of Aquifex aeolicus KDO8P Synthase: Role of the L7 Loop
Biochemistry, 44, 2005
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1ZCO
 | | Crystal structure of pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase | | 分子名称: | 2-dehydro-3-deoxyphosphoheptonate aldolase, CHLORIDE ION, MANGANESE (II) ION, ... | | 著者 | Schofield, L.R, Anderson, B.F, Patchett, M.L, Norris, G.E, Jameson, G.B, Parker, E.J. | | 登録日 | 2005-04-12 | | 公開日 | 2005-10-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Substrate Ambiguity and Crystal Structure of Pyrococcus furiosus 3-Deoxy-d-arabino-heptulosonate-7-phosphate Synthase: An Ancestral 3-Deoxyald-2-ulosonate-phosphate Synthase?(,)
Biochemistry, 44, 2005
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3TQK
 | | Structure of Phospho-2-dehydro-3-deoxyheptonate aldolase from Francisella tularensis SCHU S4 | | 分子名称: | ACETATE ION, CALCIUM ION, MANGANESE (II) ION, ... | | 著者 | Franklin, M.C, Cheung, J, Rudolph, M, Cassidy, M, Gary, E, Burshteyn, F, Love, J. | | 登録日 | 2011-09-09 | | 公開日 | 2011-09-21 | | 最終更新日 | 2014-08-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Rapid countermeasure discovery against Francisella tularensis based on a metabolic network reconstruction.
Plos One, 8, 2013
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