8TK5
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with HEPES | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
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8TK4
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate | 分子名称: | Dual specificity protein phosphatase 3, PHOSPHATE ION | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate To Be Published
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5Z59
| Crystal structure of Tk-PTP in the inactive form | 分子名称: | Protein-tyrosine phosphatase | 著者 | Ku, B, Yun, H.Y, Kim, S.J. | 登録日 | 2018-01-17 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | 主引用文献 | Structural study reveals the temperature-dependent conformational flexibility of Tk-PTP, a protein tyrosine phosphatase from Thermococcus kodakaraensis KOD1 PLoS ONE, 13, 2018
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5Z5B
| Crystal structure of Tk-PTP in the G95A mutant form | 分子名称: | CHLORIDE ION, FORMIC ACID, Protein-tyrosine phosphatase | 著者 | Ku, B, Yun, H.Y, Kim, S.J. | 登録日 | 2018-01-17 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural study reveals the temperature-dependent conformational flexibility of Tk-PTP, a protein tyrosine phosphatase from Thermococcus kodakaraensis KOD1 PLoS ONE, 13, 2018
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5XJV
| Two intermediate states of conformation switch in dual specificity phosphatase 13a | 分子名称: | Dual specificity protein phosphatase 13 isoform A, PHOSPHATE ION | 著者 | Wei, C.H, Min, H.G, Chun, H.J, Ryu, S.E. | 登録日 | 2017-05-04 | 公開日 | 2018-04-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Two intermediate states of the conformational switch in dual specificity phosphatase 13a Pharmacol. Res., 128, 2018
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5Z5A
| Crystal structure of Tk-PTP in the active form | 分子名称: | Protein-tyrosine phosphatase, VANADATE ION | 著者 | Ku, B, Yun, H.Y, Kim, S.J. | 登録日 | 2018-01-17 | 公開日 | 2018-07-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural study reveals the temperature-dependent conformational flexibility of Tk-PTP, a protein tyrosine phosphatase from Thermococcus kodakaraensis KOD1 PLoS ONE, 13, 2018
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6L1S
| Crystal structure of DUSP22 mutant_C88S | 分子名称: | Dual specificity protein phosphatase 22, PHOSPHATE ION | 著者 | Lai, C.H, Chang, C.C, Lyu, P.C. | 登録日 | 2019-09-30 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.3611 Å) | 主引用文献 | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
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6LVQ
| Crystal structure of DUSP22_VO4 | 分子名称: | Dual specificity protein phosphatase 22, VANADATE ION | 著者 | Lai, C.H, Lyu, P.C. | 登録日 | 2020-02-04 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
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6LOU
| Crystal structure of DUSP22 mutant_C88S/S93N | 分子名称: | Dual specificity protein phosphatase 22, PHOSPHATE ION | 著者 | Lai, C.H, Lyu, P.C. | 登録日 | 2020-01-07 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.5301 Å) | 主引用文献 | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
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6MC1
| Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one, ACETATE ION, ... | 著者 | Gannam, Z.T.K, Anderson, K.S, Bennett, A.M, Lolis, E. | 登録日 | 2018-08-30 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Sci.Signal., 13, 2020
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6LMY
| Crystal structure of DUSP22 mutant_C88S/S93A | 分子名称: | Dual specificity protein phosphatase 22, PHOSPHATE ION | 著者 | Lai, C.H, Lyu, P.C. | 登録日 | 2019-12-27 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
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6LOT
| Crystal structure of DUSP22 mutant_N128D | 分子名称: | Dual specificity protein phosphatase 22, SULFATE ION | 著者 | Lai, C.H, Lyu, P.C. | 登録日 | 2020-01-07 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases. Int J Mol Sci, 21, 2020
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3NME
| Structure of a plant phosphatase | 分子名称: | PHOSPHATE ION, SEX4 glucan phosphatase | 著者 | Vander Kooi, C.W. | 登録日 | 2010-06-22 | 公開日 | 2010-08-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for the glucan phosphatase activity of Starch Excess4. Proc.Natl.Acad.Sci.USA, 107, 2010
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6APX
| Crystal structure of human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the monobody YSX1 | 分子名称: | GLYCEROL, Maltose-binding periplasmic protein,Dual specificity protein phosphatase 1, Monobody YSX1, ... | 著者 | Gumpena, R, Lountos, G.T, Sreejith, R.K, Tropea, J.E, Cherry, S, Waugh, D.S. | 登録日 | 2017-08-18 | 公開日 | 2017-11-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.491 Å) | 主引用文献 | Crystal structure of the human dual specificity phosphatase 1 catalytic domain. Protein Sci., 27, 2018
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6D65
| Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein off7 | 分子名称: | Designed AR protein off7, ETHANOL, GLYCEROL, ... | 著者 | Gumpena, R, Lountos, G.T, Waugh, D.S. | 登録日 | 2018-04-20 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.348 Å) | 主引用文献 | MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
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4PYH
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6D66
| Crystal structure of the human dual specificity 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein mbp3_16 | 分子名称: | 1,2-ETHANEDIOL, D-ALANINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Gumpena, R, Waugh, D.S, Lountos, G.T. | 登録日 | 2018-04-20 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.226 Å) | 主引用文献 | MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6D67
| Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion (maltose bound form) in complex with the designed AR protein mbp3_16 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Designed AR protein mbp3_16, ... | 著者 | Gumpena, R, Lountos, G.T, Waugh, D.S. | 登録日 | 2018-04-20 | 公開日 | 2018-09-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | MBP-binding DARPins facilitate the crystallization of an MBP fusion protein. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6G84
| Structure of Cdc14 bound to CBK1 PxL motif | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CBK1, ... | 著者 | Mouilleron, S, Kataria, M, Uhlmann, F. | 登録日 | 2018-04-07 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase. Nat. Struct. Mol. Biol., 25, 2018
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6G86
| Structure of Cdc14 bound to SIC1 PxL motif | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, ... | 著者 | Mouilleron, S, Kataria, M, Uhlmann, F. | 登録日 | 2018-04-07 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase. Nat. Struct. Mol. Biol., 25, 2018
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6G85
| Structure of Cdc14 bound to CBK1 PxL motif | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CBK1, ... | 著者 | Mouilleron, S, Kataria, M, Uhlmann, F. | 登録日 | 2018-04-07 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.528 Å) | 主引用文献 | A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase. Nat. Struct. Mol. Biol., 25, 2018
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5XW4
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5XW5
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6RZZ
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4YR8
| Crystal structure of JNK in complex with a regulator protein | 分子名称: | CHLORIDE ION, Dual specificity protein phosphatase 16, Mitogen-activated protein kinase 8 | 著者 | Liu, X, Wang, J, Wu, J.W, Wang, Z.X. | 登録日 | 2015-03-14 | 公開日 | 2016-03-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation. Nat Commun, 7, 2016
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