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7DKL
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Crystal structure of the tandem DEP domains of DEPTOR
分子名称: DEP domain-containing mTOR-interacting protein
著者Weng, Z.F, Shen, X.X, Liu, Y.F.
登録日2020-11-24
公開日2021-12-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains.
J.Mol.Biol., 433, 2021
6SB0
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BU of 6sb0 by Molmil
cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ...
著者Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L.
登録日2019-07-18
公開日2019-10-16
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (5.5 Å)
主引用文献Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6SB2
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cryo-EM structure of mTORC1 bound to active RagA/C GTPases
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ...
著者Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L.
登録日2019-07-18
公開日2019-10-16
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (6.2 Å)
主引用文献Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6M4W
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Crystal structure of MBP fused split FKBP-FRB T2098L mutant in complex with rapamycin
分子名称: GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ...
著者Kikuchi, M, Wu, D, Inoue, T, Umehara, T.
登録日2020-03-09
公開日2020-08-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Rational design and implementation of a chemically inducible heterotrimerization system.
Nat.Methods, 17, 2020
6M4U
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Crystal structure of FKBP-FRB T2098L mutant in complex with rapamycin
分子名称: CHLORIDE ION, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Kikuchi, M, Wu, D, Inoue, T, Umehara, T.
登録日2020-03-09
公開日2020-08-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational design and implementation of a chemically inducible heterotrimerization system.
Nat.Methods, 17, 2020
7UX2
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cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Cui, Z, Hurley, J.
登録日2022-05-04
公開日2022-11-30
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Nature, 614, 2023
7U4T
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BU of 7u4t by Molmil
Human V-ATPase in state 2 with SidK and mEAK-7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, MTOR-associated protein MEAK7, ...
著者Wang, L, Fu, T.M.
登録日2022-03-01
公開日2022-08-24
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining.
Proc.Natl.Acad.Sci.USA, 119, 2022
5CUF
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X-ray crystal structure of SeMet human Sestrin2
分子名称: Sestrin-2
著者Kim, H, An, S, Ro, S.-H, Lee, J.H, Cho, U.-S.
登録日2015-07-24
公開日2016-01-13
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
Nat Commun, 6, 2015
6EHR
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The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex
分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
著者Scheffzek, K, Naschberger, A.
登録日2017-09-14
公開日2017-10-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.898 Å)
主引用文献Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
Science, 358, 2017
6U62
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Raptor-Rag-Ragulator complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Rogala, K.B, Sabatini, D.M.
登録日2019-08-29
公開日2019-10-30
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Structural basis for the docking of mTORC1 on the lysosomal surface.
Science, 366, 2019
6EHP
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BU of 6ehp by Molmil
The crystal structure of the human LAMTOR complex
分子名称: CHLORIDE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ...
著者Scheffzek, K, Naschberger, A.
登録日2017-09-14
公開日2017-10-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
Science, 358, 2017
5YK3
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human Ragulator complex
分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
著者Wu, G, Mu, Z.
登録日2017-10-12
公開日2019-01-23
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane
Cell Discov, 3, 2017
5YK5
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structure of the human Lamtor4-Lamtor5 complex
分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5
著者Wu, G, Mu, Z.
登録日2017-10-12
公開日2018-12-12
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane
Cell Discov, 3, 2017
8ER6
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BU of 8er6 by Molmil
FKBP12-FRB in Complex with Compound 11
分子名称: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1,2-ETHANEDIOL, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Tomlinson, A.C.A, Yano, J.K.
登録日2022-10-11
公開日2022-12-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
8ER7
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FKBP12-FRB in Complex with Compound 12
分子名称: (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-5,10,21-trimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Tomlinson, A.C.A, Yano, J.K.
登録日2022-10-11
公開日2022-12-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.07 Å)
主引用文献Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
8JCV
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BU of 8jcv by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode II)
分子名称: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JD2
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Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JCU
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BU of 8jcu by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I)
分子名称: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JD1
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Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state
分子名称: CHOLESTEROL, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JCW
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Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode I)
分子名称: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JD4
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Cryo-EM structure of G protein-free mGlu2-mGlu4 heterodimer in Acc state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JCY
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BU of 8jcy by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575 (dimerization mode I)
分子名称: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JCZ
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Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575 (dimerization mode III)
分子名称: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JCX
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BU of 8jcx by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode II)
分子名称: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JD0
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Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of NAM563
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(1-methylpyrazol-4-yl)-7-[[(2~{S})-2-(trifluoromethyl)morpholin-4-yl]methyl]quinoline-2-carboxamide, CHOLESTEROL, ...
著者Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
登録日2023-05-12
公開日2023-06-21
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023

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