7HHH
 
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1259335862 | | 分子名称: | 1,2-ETHANEDIOL, 1-[(1-methyl-1H-pyrazol-4-yl)methyl]piperazine, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HGB
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z33297786 | | 分子名称: | 1,2-ETHANEDIOL, 2-methoxy-N-[(4-methylphenyl)methyl]acetamide, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HG9
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z131516158 | | 分子名称: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, N-{(1R)-1-[(4S)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}acetamide, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HGQ
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z94597856 | | 分子名称: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, N,N,3,5-tetramethyl-1H-pyrazole-4-sulfonamide, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HGP
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z19735067 | | 分子名称: | 1,2-ETHANEDIOL, 2-(4-fluorophenoxy)-1-(pyrrolidin-1-yl)ethan-1-one, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HH2
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1238477757 | | 分子名称: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, N,N-dimethylpiperazine-1-carboxamide, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HHF
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1267773633 | | 分子名称: | 1,2-ETHANEDIOL, 1-(2-ethyl-1,3-thiazol-5-yl)-N-methylmethanamine, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HH6
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z54633859 | | 分子名称: | 1,2-ETHANEDIOL, 2-[methyl(pyridin-2-yl)amino]ethan-1-ol, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HHL
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1262327517 | | 分子名称: | 1,2-ETHANEDIOL, 6-methyl-N-{[(3S)-pyrrolidin-3-yl]methyl}pyridin-2-amine, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HGF
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z1262433643 | | 分子名称: | 1,2-ETHANEDIOL, 1-[(thiophen-3-yl)methyl]piperidin-4-ol, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HGT
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z354992234 | | 分子名称: | (2S,5R)-4-[(5-chloro-1,2,3-thiadiazol-4-yl)methyl]-2,5-dimethylmorpholine, 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HHA
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z53825020 | | 分子名称: | 1,2-ETHANEDIOL, 1-(ethanesulfonyl)piperidine-4-carboxylic acid, Hepatoma-derived growth factor-related protein 2, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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7HHR
 | | PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z57744712 | | 分子名称: | 1,2-ETHANEDIOL, Hepatoma-derived growth factor-related protein 2, N,N-dimethylmorpholine-4-sulfonamide, ... | | 著者 | Vantieghem, T, Osipov, E, Fearon, D, Douangamath, A, von Delft, F, Strelkov, S. | | 登録日 | 2024-08-29 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Eur.J.Med.Chem., 280, 2024
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2Q8C
 | | Crystal structure of JMJD2A in ternary complex with an histone H3K9me3 peptide and 2-oxoglutarate | | 分子名称: | 2-OXOGLUTARIC ACID, HISTONE 3 PEPTIDE, JmjC domain-containing histone demethylation protein 3A, ... | | 著者 | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | | 登録日 | 2007-06-10 | | 公開日 | 2007-07-03 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | | 主引用文献 | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
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2Q8D
 | | Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate | | 分子名称: | HISTONE 3 peptide, JmjC domain-containing histone demethylation protein 3A, NICKEL (II) ION, ... | | 著者 | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | | 登録日 | 2007-06-10 | | 公開日 | 2007-07-03 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
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2Q8E
 | | Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase | | 分子名称: | JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ... | | 著者 | Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C. | | 登録日 | 2007-06-10 | | 公開日 | 2007-07-03 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
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6AGO
 | | Crystal structure of MRG15-ASH1L Histone methyltransferase complex | | 分子名称: | Histone-lysine N-methyltransferase ASH1L, Mortality factor 4 like 1, S-ADENOSYLMETHIONINE, ... | | 著者 | Lee, Y, Song, J. | | 登録日 | 2018-08-13 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.103 Å) | | 主引用文献 | Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop.
Structure, 27, 2019
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8QZM
 | | Structure of DNMT3A1 UDR region bound to H2AK119ub nucleosome | | 分子名称: | DNA (145-MER), DNA (cytosine-5)-methyltransferase 3A, Histone H2A type 1, ... | | 著者 | Burdett, H, Wapenaar, H, Wilson, M.D. | | 登録日 | 2023-10-27 | | 公開日 | 2024-10-23 | | 最終更新日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Embo Rep., 25, 2024
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4BD3
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6IIR
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4GJZ
 | | JMJD5 in complex with 2-oxoglutarate | | 分子名称: | 2-OXOGLUTARIC ACID, BETA-MERCAPTOETHANOL, COBALT (II) ION, ... | | 著者 | Del Rizzo, P.A, Trievel, R.C. | | 登録日 | 2012-08-10 | | 公開日 | 2012-09-05 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.0481 Å) | | 主引用文献 | Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
Mol.Cell.Biol., 32, 2012
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6IIP
 | | Apo-form structure of the HRP3 PWWP domain | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hepatoma-derived growth factor-related protein 3, SULFATE ION | | 著者 | Wang, Z, Tian, W. | | 登録日 | 2018-10-07 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (0.951 Å) | | 主引用文献 | Apo-form structure of the HRP3 PWWP domain
Nucleic Acids Res., 2019
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4GJY
 | | JMJD5 in complex with N-Oxalylglycine | | 分子名称: | COBALT (II) ION, JmjC domain-containing protein 5, N-OXALYLGLYCINE | | 著者 | Del Rizzo, P.A, Trievel, R.C. | | 登録日 | 2012-08-10 | | 公開日 | 2012-09-05 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.2492 Å) | | 主引用文献 | Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
Mol.Cell.Biol., 32, 2012
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6IIQ
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6IIS
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