PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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6ZWP	p38a bound with SR348 分子名称: 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[(4-fluorophenyl)amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 著者 Schroeder, M, Roehm, S, Knapp, S, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Structural Genomics Consortium (SGC) 登録日 2020-07-28 公開日 2020-08-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208, 2020
2O85	S. Aureus thioredoxin P31T mutant 分子名称: Thioredoxin 著者 Roos, G, Loris, R, Messens, J. 登録日 2006-12-12 公開日 2007-07-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The conserved active site proline determines the reducing power of Staphylococcus aureus thioredoxin J.Mol.Biol., 368, 2007
2O9S	The second SH3 domain from ponsin 分子名称: CHLORIDE ION, Ponsin, SODIUM ION, ... 著者 Pinotsis, N, Wilmanns, M. 登録日 2006-12-14 公開日 2007-10-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (0.83 Å) 主引用文献 Paxillin and ponsin interact in nascent costameres of muscle cells J.Mol.Biol., 369, 2007
7A2H	Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-imidazo[4,5-b]pyridine 分子名称: 1,2-ETHANEDIOL, 5,6,7-tris(bromanyl)-1~{H}-imidazo[4,5-b]pyridine, Casein kinase II subunit alpha' 著者 Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. 登録日 2020-08-18 公開日 2020-12-09 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.01 Å) 主引用文献 Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
4L6Q	ROCK2 in complex with benzoxaborole 分子名称: 6-[4-(aminomethyl)-2-fluorophenoxy]-2,1-benzoxaborol-1(3H)-ol, Rho-associated protein kinase 2 著者 Rock, F, Jarnagin, K. 登録日 2013-06-12 公開日 2013-10-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors. J.Pharmacol.Exp.Ther., 347, 2013
7A4C	Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine 分子名称: 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, GLYCEROL, ... 著者 Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. 登録日 2020-08-19 公開日 2020-12-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
2IC5	Crystal structure of human RAC3 grown in the presence of Gpp(NH)p. 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ugochukwu, E, Yang, X, Zao, Y, Elkins, J, Gileadi, C, Burgess, N, Colebrook, S, Gileadi, O, Fedorov, O, Bunkoczi, G, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, von Delft, F, Doyle, D, Structural Genomics Consortium (SGC) 登録日 2006-09-12 公開日 2006-10-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of human RAC3 grown in the presence of Gpp(NH)p. To be Published
2IC2	Crystal Structure of the First FNIII Domain of Ihog 分子名称: CG9211-PA, SULFATE ION 著者 McLellan, J.S, Leahy, D.J. 登録日 2006-09-12 公開日 2006-10-24 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc.Natl.Acad.Sci.Usa, 103, 2006
2NT3	Receiver domain from Myxococcus xanthus social motility protein FrzS (Y102A Mutant) 分子名称: Response regulator homolog 著者 Fraser, J.S, Echols, N, Merlie, J.P, Zusman, D.R, Alber, T. 登録日 2006-11-06 公開日 2007-03-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS. Mol.Microbiol., 65, 2007
2NUI	X-ray Structure of synthetic [D83A]RNase A 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Ribonuclease pancreatic 著者 Boerema, D.J, Tereshko, V.A, Kent, S.B.H. 登録日 2006-11-09 公開日 2007-10-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Total synthesis by modern chemical ligation methods and high resolution (1.1 A) X-ray structure of ribonuclease A Biopolymers, 90, 2008
2IEZ	Crystal Structure of mouse Rab27b bound to GDP in monoclinic space group 分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-27B 著者 Chavas, L.M.G, Torii, S, Kamikubo, H, Kawasaki, M, Ihara, K, Kato, R, Kataoka, M, Izumi, T, Wakatsuki, S. 登録日 2006-09-19 公開日 2007-05-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of the small GTPase Rab27b shows an unexpected swapped dimer Acta Crystallogr.,Sect.D, 63, 2007
2IHX	Solution Structure of the Rous Sarcoma Virus Nucleocapsid Protein:uPsi RNA Packaging Signal Complex 分子名称: Nucleocapsid (NC) Protein, ZINC ION, uPsi RNA 著者 Zhou, J, Summers, M. 登録日 2006-09-27 公開日 2007-01-16 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of the Rous Sarcoma Virus Nucleocapsid Protein: muPsi RNA Packaging Signal Complex. J.Mol.Biol., 365, 2007
6ZR5	Crystal structure of JNK1 in complex with ATF2(19-58) 分子名称: Cyclic AMP-dependent transcription factor ATF-2, MAGNESIUM ION, Mitogen-activated protein kinase 8, ... 著者 Kirsch, K, Zeke, A, Remenyi, A. 登録日 2020-07-10 公開日 2020-11-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.699 Å) 主引用文献 Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. Nat Commun, 11, 2020
2HZQ	Crystal structure of human apolipoprotein D (ApoD) in complex with progesterone 分子名称: Apolipoprotein D, PROGESTERONE 著者 Eichinger, A, Skerra, A. 登録日 2006-08-09 公開日 2007-08-14 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein d. J.Biol.Chem., 282, 2007
7A4O	Structure of DYRK1A in complex with AMPNP 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A53	Structure of DYRK1A in complex with compound 7 分子名称: (3~{E})-3-[(5-methylfuran-2-yl)methylidene]-1~{H}-indol-2-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A4S	Structure of DYRK1A in complex with compound 2 分子名称: 7-chlorothieno[3,2-c]pyridin-4-amine, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A4Z	Structure of DYRK1A in complex with compound 4 分子名称: 3-(4-methoxyphenyl)-1~{H}-pyrazol-5-amine, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A4R	Structure of DYRK1A in complex with compound 1 分子名称: 2-amino-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A52	Structure of DYRK1A in complex with compound 6 分子名称: 3-phenyl-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ... 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A55	Structure of DYRK1A in complex with compound 8 分子名称: 3-(1-methylpyrazol-4-yl)-1~{H}-pyrazole-5-carboxylic acid, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A5N	Structure of DYRK1A in complex with compound 34 分子名称: 5-(2-azanylpyridin-4-yl)-~{N}-[[2,6-bis(fluoranyl)phenyl]methyl]-2-methyl-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-21 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A4W	Structure of DYRK1A in complex with compound 3 分子名称: 6-(4-methoxyphenyl)pyrimidine-2,4-diamine, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A5B	Structure of DYRK1A in complex with complex 10 分子名称: 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-20 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021
7A5D	Structure of DYRK1A in complex with compound 16 分子名称: 4-azanyl-2-methyl-6-pyridin-3-yl-7~{H}-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, CHLORIDE ION, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Dokurno, P, Surgenor, A.E, Hubbard, R.E. 登録日 2020-08-21 公開日 2021-06-30 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J.Med.Chem., 64, 2021

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