6MJX
| human cGAS catalytic domain bound with cGAMP | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION, cGAMP | 著者 | Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T. | 登録日 | 2018-09-23 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10, 2019
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6MK6
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6MJU
| human cGAS catalytic domain bound with the inhibitor G108 | 分子名称: | 1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Lama, L, Adura, C, Xie, W, Tomita, D, Kamei, T, Kuryavyi, V, Gogakos, T, Steinberg, J.I, Miller, M, Ramos-Espiritu, L, Asano, Y, Hashizume, S, Aida, J, Imaeda, T, Okamoto, R, Jennings, A.J, Michinom, M, Kuroita, T, Stamford, A, Gao, P, Meinke, P, Glickman, J.F, Patel, D.J, Tuschl, T. | 登録日 | 2018-09-22 | 公開日 | 2019-05-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun, 10, 2019
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6MO9
| N-terminal bromodomain of human BRD2 in complex with N-cyclopentyl-7-(3,5-dimethylisoxazol-4-yl)quinoline-5-sulfonamide inhibitor | 分子名称: | Bromodomain-containing protein 2, N-cyclopentyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-5-sulfonamide | 著者 | Lansdon, E.B, Newby, Z.E.R. | 登録日 | 2018-10-04 | 公開日 | 2019-01-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg. Med. Chem., 27, 2019
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4NP8
| Structure of an amyloid forming peptide VQIVYK from the second repeat region of tau (alternate polymorph) | 分子名称: | Microtubule-associated protein tau | 著者 | Landau, M, Eisenberg, D, Sawaya, M.R, Dannenberg, J, Kobko, N. | 登録日 | 2013-11-20 | 公開日 | 2013-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Molecular mechanisms for protein-encoded inheritance. Nat.Struct.Mol.Biol., 16, 2009
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6MZC
| Human TFIID BC core | 分子名称: | Transcription initiation factor TFIID subunit 10, Transcription initiation factor TFIID subunit 12, Transcription initiation factor TFIID subunit 2, ... | 著者 | Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. | 登録日 | 2018-11-05 | 公開日 | 2018-11-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
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6MO8
| N-terminal bromodomain of human BRD2 in complex with 4,4'-(quinoline-5,7-diyl)bis(3,5-dimethylisoxazole) inhibitor | 分子名称: | 5,7-bis(3,5-dimethyl-1,2-oxazol-4-yl)quinoline, Bromodomain-containing protein 2, SULFATE ION | 著者 | Lansdon, E.B, Newby, Z.E.R. | 登録日 | 2018-10-04 | 公開日 | 2019-01-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg. Med. Chem., 27, 2019
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6MRM
| Red Clover Necrotic Mosaic Virus | 分子名称: | CALCIUM ION, Capsid protein | 著者 | Sherman, M.B, Smith, T.J. | 登録日 | 2018-10-14 | 公開日 | 2019-10-16 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Near-Atomic-Resolution Cryo-Electron Microscopy Structures of Cucumber Leaf Spot Virus and Red Clover Necrotic Mosaic Virus: Evolutionary Divergence at the Icosahedral Three-Fold Axes. J.Virol., 94, 2020
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6MZM
| Human TFIID bound to promoter DNA and TFIIA | 分子名称: | SCP DNA (80-MER), TATA-box-binding protein, Transcription initiation factor IIA subunit 1, ... | 著者 | Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. | 登録日 | 2018-11-05 | 公開日 | 2018-11-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | 主引用文献 | Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
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6MZD
| Human TFIID Lobe A canonical | 分子名称: | TATA-box-binding protein, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 10, ... | 著者 | Patel, A.B, Louder, R.K, Greber, B.J, Grunberg, S, Luo, J, Fang, J, Liu, Y, Ranish, J, Hahn, S, Nogales, E. | 登録日 | 2018-11-05 | 公開日 | 2018-11-28 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (9.8 Å) | 主引用文献 | Structure of human TFIID and mechanism of TBP loading onto promoter DNA. Science, 362, 2018
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6N5H
| Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 5 | 分子名称: | 4-[(trans-4-{[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-ylcarbamoyl]amino}cyclohexyl)oxy]benzoic acid, Epoxide hydrolase TrEH | 著者 | Oliveira, G.S, Adriano, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S. | 登録日 | 2018-11-21 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.717 Å) | 主引用文献 | The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors Int. J. Biol. Macromol., 129, 2019
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6N6B
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6N5F
| Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 3 | 分子名称: | Epoxide hydrolase TrEH, N-(8-amino-8-oxooctyl)nonanamide | 著者 | Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S. | 登録日 | 2018-11-21 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. Int. J. Biol. Macromol., 129, 2019
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6N5G
| Crystal structure of an epoxide hydrolase from Trichoderma reesei in complex with inhibitor 2 | 分子名称: | 4-[(quinolin-3-yl)methyl]-N-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxamide, Epoxide hydrolase TrEH | 著者 | Oliveira, G.S, Adriani, P.P, Ribeiro, J.A, Morisseau, C, Hammock, B.D, Dias, M.V, Chambergo, F.S. | 登録日 | 2018-11-21 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. Int. J. Biol. Macromol., 129, 2019
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6MRL
| Cucumber Leaf Spot Virus | 分子名称: | CALCIUM ION, p41 | 著者 | Sherman, M.B, Smith, T.J. | 登録日 | 2018-10-14 | 公開日 | 2019-10-16 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Near-Atomic-Resolution Cryo-Electron Microscopy Structures of Cucumber Leaf Spot Virus and Red Clover Necrotic Mosaic Virus: Evolutionary Divergence at the Icosahedral Three-Fold Axes. J.Virol., 94, 2020
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6NE7
| Structure of G810A mutant of RET protein tyrosine kinase domain. | 分子名称: | ADENOSINE MONOPHOSPHATE, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret | 著者 | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | 登録日 | 2018-12-17 | 公開日 | 2019-06-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294, 2019
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6NOG
| Poised-state Dot1L bound to the H2B-Ubiquitinated nucleosome | 分子名称: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | 著者 | Worden, E.J, Hoffmann, N.A, Wolberger, C. | 登録日 | 2019-01-16 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Cell, 176, 2019
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6NT2
| type 1 PRMT in complex with the inhibitor GSK3368715 | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, N~1~-({5-[4,4-bis(ethoxymethyl)cyclohexyl]-1H-pyrazol-4-yl}methyl)-N~1~,N~2~-dimethylethane-1,2-diamine, ... | 著者 | Concha, N.O. | 登録日 | 2019-01-28 | 公開日 | 2019-07-10 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell, 36, 2019
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6NEC
| STRUCTURE OF RET PROTEIN TYROSINE KINASE DOMAIN IN COMPLEX WITH NINTEDANIB | 分子名称: | FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret, methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | 著者 | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | 登録日 | 2018-12-17 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294, 2019
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6NJ9
| Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 2-to-1 complex | 分子名称: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H2A type 1, ... | 著者 | Worden, E.J, Hoffmann, N.A, Wolberger, C. | 登録日 | 2019-01-02 | 公開日 | 2019-02-20 | 最終更新日 | 2021-06-16 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L. Cell, 176, 2019
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6O0E
| Saxiphilin:STX complex, soaking | 分子名称: | Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | 著者 | Yen, T.J, Lolicato, M, Minor, D.L. | 登録日 | 2019-02-16 | 公開日 | 2019-07-10 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins. Sci Adv, 5, 2019
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6NJA
| Structure of WT RET protein tyrosine kinase domain at 1.92A resolution. | 分子名称: | ADENINE, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret | 著者 | Terzyan, S.S, Shen, T, Wu, J, Mooers, B.H.M. | 登録日 | 2019-01-02 | 公開日 | 2019-06-05 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J.Biol.Chem., 294, 2019
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4HGP
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6NKE
| Wild-type GGGPS from Thermoplasma volcanium | 分子名称: | GLYCEROL, Geranylgeranylglyceryl phosphate synthase, IMIDAZOLE, ... | 著者 | Blank, P.N, Alderfer, K.E, Gillott, B.N, Christianson, D.W, Himmelberger, J.A. | 登録日 | 2019-01-07 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota. Acta Crystallogr D Struct Biol, 76, 2020
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6N7Y
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