PDB: 97138 件ウェブページステータス検索Chemie searchBIRD

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5KFI	Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 120s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFT	Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 40s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KG5	Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 10 mM Cd2+ for 60s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*TP*A)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFB	Human DNA polymerase eta-DNA ternary complex: reaction with 1 mM Mn2+ for 90s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFM	Human DNA polymerase eta-DNA ternary complex with Sp-dATP-alpha-S: ground state at pH7.0 (K+ MES) with 1 Ca2+ ion 分子名称: 2'-DEOXYADENOSINE 5'-O-(1-THIOTRIPHOSPHATE), CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
5KFW	Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 200s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
3LSQ	Trypanosoma brucei seryl-tRNA synthetase 分子名称: MALONATE ION, SODIUM ION, Seryl-tRNA synthetase 著者 Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) 登録日 2010-02-12 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray crystal structure of Seryl-tRNA synthetase from the eukaryotic parasite Trypanosoma brucei. to be published
5KN7	Lipid A secondary acyltransferase LpxM from Acinetobacter baumannii 分子名称: DODECYL-BETA-D-MALTOSIDE, GLYCEROL, Lipid A biosynthesis lauroyl acyltransferase, ... 著者 Dovala, D.L, Hu, Q, Metzger IV, L.E. 登録日 2016-06-27 公開日 2016-09-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
5KJ2	The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer 分子名称: Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION 著者 Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C. 登録日 2016-06-17 公開日 2017-09-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature, 550, 2017
5KLH	Crystal Structure of Trypanosoma brucei Procyclic Specific Surface Antigen-2 分子名称: SULFATE ION, Surface glycoprotein 著者 Ramaswamy, R, Parker, M.L, Boulanger, M.J. 登録日 2016-06-24 公開日 2017-07-05 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (1.646 Å) 主引用文献 Structural characterization reveals a novel bilobed architecture for the ectodomains of insect stage expressed Trypanosoma brucei PSSA-2 and Trypanosoma congolense ISA. Protein Sci., 25, 2016
7WNZ	CryoEM structure of human alpha-synuclein A53T fibril 分子名称: Alpha-synuclein 著者 Wu, K.-P, Huang, J.Y.-C. 登録日 2022-01-20 公開日 2023-01-25 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Calcium abolishes intramolecular long-range contacts and promotes hereditary alpha-synuclein A53T aggregation To Be Published
6GQ4	Neisseria gonorrhoeae Adhesin Complex Protein 分子名称: Adhesin, SODIUM ION 著者 Orr, C.M, Tews, I. 登録日 2018-06-07 公開日 2018-09-19 最終更新日 2018-10-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure of the RecombinantNeisseria gonorrhoeaeAdhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci. mSphere, 3, 2018
2D32	Crystal Structure of Michaelis Complex of gamma-Glutamylcysteine Synthetase 分子名称: CYSTEINE, GLUTAMIC ACID, Glutamate--cysteine ligase, ... 著者 Hibi, T, Nakayama, M, Nii, H, Kurokawa, Y, Katano, H, Oda, J. 登録日 2005-09-25 公開日 2006-11-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis of efficient coupling peptide ligation and ATP hydrolysis by gamma-gluatamylcysteine synthetase To be Published
1WTU	TRANSCRIPTION FACTOR 1, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: TRANSCRIPTION FACTOR 1 著者 Jia, X, Grove, A, Ivancic, M, Hsu, V.L, Geiduschek, E.P, Kearns, D.R. 登録日 1996-07-29 公開日 1997-02-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of the Bacillus subtilis phage SPO1-encoded type II DNA-binding protein TF1 in solution. J.Mol.Biol., 263, 1996
7WWO	Dimer form of hypothetical protein TTHA1873 from Thermus thermophilus 分子名称: CALCIUM ION, hypothetical protein TTHA1873 著者 Yuvaraj, I, Sekar, K. 登録日 2022-02-14 公開日 2022-03-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structure of the hypothetical protein TTHA1873 from Thermus thermophilus. Acta Crystallogr.,Sect.F, 78, 2022
7WWN	Structure of hypothetical protein TTHA1873 from Thermus thermophilus with Potassium mercuric iodide 分子名称: CALCIUM ION, hypothetical protein TTHA1873, tetraiodomercurate(2-) 著者 Yuvaraj, I, Sekar, K. 登録日 2022-02-14 公開日 2022-04-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure of the hypothetical protein TTHA1873 from Thermus thermophilus. Acta Crystallogr.,Sect.F, 78, 2022
5KNK	Lipid A secondary acyltransferase LpxM from Acinetobacter baumannii with catalytic residue substitution (E127A) 分子名称: DODECYL-BETA-D-MALTOSIDE, GLYCEROL, Lipid A biosynthesis lauroyl acyltransferase, ... 著者 Dovala, D.L, Hu, Q, Metzger IV, L.E. 登録日 2016-06-28 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
2D33	Crystal Structure of gamma-Glutamylcysteine Synthetase Complexed with Aluminum Fluoride 分子名称: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CYSTEINE, ... 著者 Hibi, T, Nakayama, M, Nii, H, Kurokawa, Y, Katano, H, Oda, J. 登録日 2005-09-25 公開日 2006-11-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of efficient coupling between peptide ligation and ATP hydrolysis by gamma-gluatamylcysteine synthetase To be Published
3LIM	Crystal structure of the pore forming toxin frac from sea anemone actinia fragacea 分子名称: Fragaceatoxin C, LAURYL DIMETHYLAMINE-N-OXIDE 著者 Mechaly, A.E, Bellomio, A, Morante, K, Gonzalez-Manas, J.M, Guerin, D.M.A. 登録日 2010-01-25 公開日 2010-12-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins. Structure, 19, 2011
4TPP	2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors 分子名称: 1-[4-(3-{[1-(quinolin-2-yl)azetidin-3-yl]oxy}quinoxalin-2-yl)piperidin-1-yl]ethanone, GLYCEROL, SULFATE ION, ... 著者 Chmait, S. 登録日 2014-06-09 公開日 2014-12-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Bioorg.Med.Chem., 22, 2014
6UEX	Crystal structure of S. aureus LcpA in complex with octaprenyl-pyrophosphate-GlcNAc 分子名称: 2-(acetylamino)-2-deoxy-1-O-[(S)-hydroxy{[(S)-hydroxy{[(2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl]oxy}phosphoryl]oxy}phosphoryl]-alpha-D-glucopyranose, GLYCEROL, Regulatory protein MsrR, ... 著者 Li, F.K.K, Strynadka, N.C.J. 登録日 2019-09-23 公開日 2020-01-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic analysis ofStaphylococcus aureusLcpA, the primary wall teichoic acid ligase. J.Biol.Chem., 295, 2020
7X5V	NaVEh Sodium channel, and NaVEh from the coccolithophore Emiliania huxleyi 分子名称: ion channel, ion channel,GFP-TwinStrep 著者 Jiang, D, Zhang, J. 登録日 2022-03-05 公開日 2022-06-01 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 N-type fast inactivation of a eukaryotic voltage-gated sodium channel. Nat Commun, 13, 2022
5KMX	Structure of Trypanosoma congolense Insect Stage Antigen 分子名称: GLYCEROL, Putative uncharacterized protein TCIL3000_10_9440, SULFATE ION 著者 Ramaswamy, R, Parker, M.L, Boulanger, M.J. 登録日 2016-06-27 公開日 2017-07-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.452 Å) 主引用文献 Structural characterization reveals a novel bilobed architecture for the ectodomains of insect stage expressed Trypanosoma brucei PSSA-2 and Trypanosoma congolense ISA. Protein Sci., 25, 2016
4Z9O	Crystal Structure of human GGT1 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Terzyan, S.S, Hanigan, M.H. 登録日 2015-04-10 公開日 2015-06-03 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J.Biol.Chem., 290, 2015
6H8S	CRYSTAL STRUCTURE OF THE MOUSE PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND BI-0314 分子名称: 1-[3-piperidin-4-yl-5-(trifluoromethyl)phenyl]guanidine, Tyrosine-protein phosphatase non-receptor type 5 著者 Fiegen, D, Schnapp, G. 登録日 2018-08-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.771 Å) 主引用文献 Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. J. Med. Chem., 62, 2019

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