4TZT
| CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ENOYL REDUCTASE (INHA) COMPLEXED WITH N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL- 5-OXOPYRROLIDINE-3-CARBOXAMIDE | 分子名称: | (3S)-N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | He, X, Alian, A, Stroud, R.M, Ortiz de Montellano, P.R. | 登録日 | 2014-07-10 | 公開日 | 2014-08-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis J. Med. Chem., 2006
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6VUX
| Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT388 | 分子名称: | 2-{[(7S)-4-amino-7-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-[2-(piperidin-1-yl)ethyl]acetamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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5W8P
| Homoserine transacetylase MetX from Mycobacterium abscessus | 分子名称: | GLYCEROL, Homoserine O-acetyltransferase, PHOSPHATE ION, ... | 著者 | Rodriguez, E.S, Reed, R.W, Korotkov, K.V. | 登録日 | 2017-06-22 | 公開日 | 2017-07-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site. Sci Rep, 9, 2019
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1A7Z
| CRYSTAL STRUCTURE OF ACTINOMYCIN Z3 | 分子名称: | ACTINOMYCIN Z3, BENZENE | 著者 | Schafer, M. | 登録日 | 1998-03-19 | 公開日 | 1999-03-23 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | Crystal Structures of Actinomycin D and Actinomycin Z3. Angew.Chem.Int.Ed.Engl., 37, 1998
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8IMH
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3NFW
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4QA8
| Crystal structure of LprF from Mycobacterium bovis | 分子名称: | (2R)-2-(dodecanoyloxy)propyl (4E,6E,8E,10E,12E)-pentadeca-4,6,8,10,12-pentaenoate, Putative lipoprotein LprF | 著者 | Ha, N.C, Jiao, L, Kim, J.S. | 登録日 | 2014-05-02 | 公開日 | 2014-10-22 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Crystal structure and functional implications of LprF from Mycobacterium tuberculosis and M. bovis Acta Crystallogr.,Sect.D, 70, 2014
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3MI0
| Crystal Structure of Mycobacterium Tuberculosis Proteasome at 2.2 A | 分子名称: | (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-4-ethyl-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carbaldehyde, DIMETHYLFORMAMIDE, Proteasome subunit alpha, ... | 著者 | Li, D, Li, H. | 登録日 | 2010-04-09 | 公開日 | 2010-06-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome. Embo J., 2010
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4QII
| Crystal Structure of type II MenB from Mycobacteria tuberculosis | 分子名称: | 1,4-Dihydroxy-2-naphthoyl-CoA synthase, Salicylyl CoA, TRIETHYLENE GLYCOL | 著者 | Song, H.G, Tse, Y.S, Sung, H.P, Guo, Z.H. | 登録日 | 2014-05-31 | 公開日 | 2014-11-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues Acta Crystallogr.,Sect.D, 70, 2014
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4QIJ
| Crystal structure of MenB from Mycobacteria tuberculosis in complex with 1-HNA-CoA | 分子名称: | 1,4-Dihydroxy-2-naphthoyl-CoA synthase, 1-hydroxy-2-naphthoyl-CoA | 著者 | Song, H.G, Sung, H.P, Tse, Y.S, Guo, Z.H. | 登録日 | 2014-05-31 | 公開日 | 2014-11-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues Acta Crystallogr.,Sect.D, 70, 2014
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5KDE
| Inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with inhibitor 1 and inorganic pyrophosphate | 分子名称: | 2,4-bis(aziridin-1-yl)-6-(1-phenylpyrrol-2-yl)-1,3,5-triazine, Inorganic pyrophosphatase, PYROPHOSPHATE 2- | 著者 | Pang, A.H, Garzan, A, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2016-06-08 | 公開日 | 2016-09-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis. ACS Chem. Biol., 11, 2016
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5KGT
| Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with an inhibitor optimized from HTS lead: 1-[4-[4-(3-chlorophenyl)carbonylpiperidin-1-yl]phenyl]ethanone | 分子名称: | 1-[4-[4-(3-chlorophenyl)carbonylpiperidin-1-yl]phenyl]ethanone, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Maize, K.M, Divakaran, A, Aldrich, C.C, Finzel, B.C. | 登録日 | 2016-06-13 | 公開日 | 2017-06-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis. J. Med. Chem., 60, 2017
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5KDF
| Inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with inhibitor 6 and inorganic pyrophosphate | 分子名称: | CALCIUM ION, Inorganic pyrophosphatase, PYROPHOSPHATE 2-, ... | 著者 | Pang, A.H, Garzan, A, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2016-06-08 | 公開日 | 2016-09-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis. ACS Chem. Biol., 11, 2016
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5KGS
| Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with an inhibitor optimized from HTS lead: 5-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]-2,3-dihydroinden-1-one | 分子名称: | 5-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]-2,3-dihydroinden-1-one, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Maize, K.M, Aldrich, C.C, Finzel, B.C. | 登録日 | 2016-06-13 | 公開日 | 2017-06-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis. J. Med. Chem., 60, 2017
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6R1B
| Crystal structure of UgpB from Mycobacterium tuberculosis in complex with glycerophosphocholine | 分子名称: | 2-(((R)-2,3-DIHYDROXYPROPYL)PHOSPHORYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM, GLYCEROL, MAGNESIUM ION, ... | 著者 | Fenn, J, Nepravishta, R, Guy, C.S, Harrison, J, Angulo, J, Cameron, A.D, Fullam, E. | 登録日 | 2019-03-14 | 公開日 | 2019-09-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.27000213 Å) | 主引用文献 | Structural Basis of Glycerophosphodiester Recognition by theMycobacterium tuberculosisSubstrate-Binding Protein UgpB. Acs Chem.Biol., 14, 2019
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6H53
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5CRF
| Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis | 分子名称: | PHOSPHATE ION, Penicillin-binding protein 1A | 著者 | Filippova, E.V, Wawrzak, Z, Kiryukhina, O, Kieser, K, Endres, M, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) | 登録日 | 2015-07-22 | 公開日 | 2016-05-04 | 最終更新日 | 2016-07-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. Febs J., 283, 2016
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4RFV
| Structure of the Mycobacterium tuberculosis APS kinase CysC Cys556Ala mutant | 分子名称: | Bifunctional enzyme CysN/CysC, PHOSPHATE ION | 著者 | Poyraz, O, Brunner, K, Schnell, R, Schneider, G. | 登録日 | 2014-09-28 | 公開日 | 2015-01-28 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis. Plos One, 10, 2015
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5YOI
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6ID6
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5YOH
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5CXW
| Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V | 分子名称: | (2R,4S)-5,5-dimethyl-2-{(1R)-2-oxo-1-[(phenoxyacetyl)amino]ethyl}-1,3-thiazolidine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Filippova, E.V, Kiryukhina, O, Kieser, K, Endres, M, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) | 登録日 | 2015-07-29 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. Febs J., 283, 2016
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4Z0M
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5O4L
| Crystal structure of P450 CYP121 in complex with compound 6a. | 分子名称: | 1-[(4-fluorophenyl)methyl]-4-(3-imidazol-1-ylpropyl)piperazin-2-one, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Levy, C.W. | 登録日 | 2017-05-29 | 公開日 | 2018-03-28 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation. J. Med. Chem., 60, 2017
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3MKA
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