PDB: 10530 件ウェブページステータス検索Chemie searchBIRD

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8HR2	Ternary Crystal Complex Structure of RBD with NB1B5 and NB1C6 分子名称: NB1B5, NB1C6, Spike protein S1 著者 Sun, Z. 登録日 2022-12-14 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes. J.Struct.Biol., 215, 2023
8ZH4	HIV-1 integrase core domain in complex with compound 5 分子名称: (2~{S})-2-(4',5-dimethylspiro[1,2-dihydroindene-3,1'-cyclohexane]-4-yl)-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, SULFATE ION, ... 著者 Furuzono, T, Orita, T, Nomura, A, Adachi, T. 登録日 2024-05-10 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorg.Med.Chem.Lett., 2024
8ZHA	HIV-1 integrase core domain in complex with compound 15 分子名称: (2~{S})-2-[7-(cycloheptylcarbamoyl)-4',5-dimethyl-spiro[1,2-dihydroindene-3,1'-cyclohexane]-4-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, SULFATE ION, ... 著者 Furuzono, T, Orita, T, Nomura, A, Adachi, T. 登録日 2024-05-10 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. Bioorg.Med.Chem.Lett., 2024
4LKQ	Crystal structure of PDE10A2 with fragment ZT017 分子名称: 4-amino-1,7-dihydro-6H-pyrazolo[3,4-d]pyrimidine-6-thione, NICKEL (II) ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 著者 Sridhar, V, Badger, J, Logan, C, Chie-Leon, B, Nienaber, V. 登録日 2013-07-08 公開日 2014-02-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography. J Biomol Screen, 19, 2014
1X1W	Water-mediate interaction at aprotein-protein interface 分子名称: Barstar, Ribonuclease 著者 Ikura, T, Urakubo, Y, Ito, N. 登録日 2005-04-14 公開日 2005-04-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Water-mediated interaction at a protein-protein interface Chem.Phys., 307, 2004
1BNS	STRUCTURAL STUDIES OF BARNASE MUTANTS 分子名称: BARNASE 著者 Chen, Y.W. 登録日 1994-04-11 公開日 1994-06-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Contribution of buried hydrogen bonds to protein stability. The crystal structures of two barnase mutants. J.Mol.Biol., 234, 1993
6S50	scdSav(SARK)mv2 - Engineering Single-Chain Dimeric Streptavidin as Host for Artificial Metalloenzymes 分子名称: GLYCEROL, SULFATE ION, Streptavidin, ... 著者 Rebelein, J.G. 登録日 2019-06-29 公開日 2019-09-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Breaking Symmetry: Engineering Single-Chain Dimeric Streptavidin as Host for Artificial Metalloenzymes. J.Am.Chem.Soc., 141, 2019
6LSR	Cryo-EM structure of a pre-60S ribosomal subunit - state B 分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Liang, X, Zuo, M, Zhang, Y, Li, N, Ma, C, Dong, M, Gao, N. 登録日 2020-01-20 公開日 2020-08-26 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat Commun, 11, 2020
7PD9	Crystal structure of CD73 in complex with riboflavin in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-04 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
4X2R	Crystal structure of PriA from Actinomyces urogenitalis 分子名称: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, PHOSPHATE ION 著者 MICHALSKA, K, VERDUZCO-CASTRO, E.A, ENDRES, M, BARONA-GOMEZ, F, JOACHIMIAK, A, Midwest Center for Structural Genomics (MCSG) 登録日 2014-11-26 公開日 2014-12-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Evolution of substrate specificity in a retained enzyme driven by gene loss. Elife, 6, 2017
1BRS	PROTEIN-PROTEIN RECOGNITION: CRYSTAL STRUCTURAL ANALYSIS OF A BARNASE-BARSTAR COMPLEX AT 2.0-A RESOLUTION 分子名称: BARNASE, BARSTAR 著者 Buckle, A.M, Schreiber, G, Fersht, A.R. 登録日 1994-03-11 公開日 1994-06-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-A resolution. Biochemistry, 33, 1994
1BSE	CRYSTAL STRUCTURAL ANALYSIS OF MUTATIONS IN THE HYDROPHOBIC CORES OF BARNASE 分子名称: BARNASE 著者 Buckle, A.M, Henrick, K, Fersht, A.R. 登録日 1993-07-19 公開日 1994-01-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structural analysis of mutations in the hydrophobic cores of barnase. J.Mol.Biol., 234, 1993
6YJY	Crystal structure of human glutaminyl cyclase in complex with neurotensin 1-5 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTAMINE, Glutaminyl-peptide cyclotransferase, ... 著者 Funk, L.M, Sautner, V, Tittmann, K. 登録日 2020-04-05 公開日 2020-07-01 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease. Biochemistry, 59, 2020
1KBI	Crystallographic Study of the Recombinant Flavin-binding Domain of Baker's Yeast Flavocytochrome b2: Comparison with the Intact Wild-type Enzyme 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOCHROME B2, FLAVIN MONONUCLEOTIDE, ... 著者 Cunane, L.M, Barton, J.D, Chen, Z.-W, Welsh, F.E, Chapman, S.K, Reid, G.A, Mathews, F.S. 登録日 2001-11-06 公開日 2002-04-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystallographic study of the recombinant flavin-binding domain of Baker's yeast flavocytochrome b(2): comparison with the intact wild-type enzyme. Biochemistry, 41, 2002
8P6Q	Racemic structure of TNFR1 cysteine-rich domain 分子名称: D-TNFR-1 CRD2, SULFATE ION, Tumor necrosis factor-binding protein 1 著者 Lander, A.J, Jin, Y, Luk, L.Y.P. 登録日 2023-05-28 公開日 2024-01-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery. Acs Bio Med Chem Au, 4, 2024
1BRI	BARNASE MUTANT WITH ILE 76 REPLACED BY ALA 分子名称: BARNASE 著者 Cramer, P.C, Buckle, A, Fersht, A. 登録日 1995-03-09 公開日 1995-07-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities. Biochemistry, 35, 1996
6OSO	The crystal structure of the isolate tryptophan synthase alpha-chain from Salmonella enterica serovar typhimurium at 1.75 Angstrom resolution 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, SULFATE ION, ... 著者 Hilario, E, Dunn, M.F, Mueller, L, Chang, C, Fan, L. 登録日 2019-05-01 公開日 2020-05-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Backbone assignments and conformational dynamics in the S. typhimurium tryptophan synthase alpha-subunit from solution-state NMR. J.Biomol.Nmr, 74, 2020
6AHS	Mouse Kallikrein 7 in complex with imidazolinylindole derivative 分子名称: 1-[(2-chlorophenyl)sulfonyl]-5-methyl-3-[(4R)-2-methyl-4,5-dihydro-1H-imidazol-4-yl]-1H-indole, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Sugawara, H. 登録日 2018-08-20 公開日 2019-01-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors. Bioorg. Med. Chem. Lett., 29, 2019
6OUY	The crystal structure of the isolate tryptophan synthase alpha-chain from Salmonella enterica serovar typhimurium at 1.60 Angstrom resolution 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, SULFATE ION, ... 著者 Hilario, E, Dunn, M.F, Mueller, L, Chang, C, Fan, L. 登録日 2019-05-06 公開日 2020-05-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Backbone assignments and conformational dynamics in the S. typhimurium tryptophan synthase alpha-subunit from solution-state NMR. J.Biomol.Nmr, 74, 2020
6OWV	Crystal structure of a Human Cardiac Calsequestrin Filament 分子名称: CHLORIDE ION, Calsequestrin-2, SULFATE ION 著者 Titus, E.W, Deiter, F.H, Shi, C, Jura, N, Deo, R.C. 登録日 2019-05-12 公開日 2020-07-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia. Nat.Struct.Mol.Biol., 27, 2020
6ERE	Crystal structure of a computationally designed colicin endonuclease and immunity pair colEdes3/Imdes3 分子名称: Immunity, PHOSPHATE ION, colicin 著者 Netzer, R, Listov, D, Dym, O, Albeck, S, Knop, O, Fleishman, S.J. 登録日 2017-10-18 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Ultrahigh specificity in a network of computationally designed protein-interaction pairs. Nat Commun, 9, 2018
1BNR	BARNASE 分子名称: BARNASE (G SPECIFIC ENDONUCLEASE) 著者 Bycroft, M. 登録日 1995-03-31 公開日 1995-07-31 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy. Biochemistry, 30, 1991
1BNF	BARNASE T70C/S92C DISULFIDE MUTANT 分子名称: BARNASE 著者 Clarke, J, Henrick, K, Fersht, A.R. 登録日 1995-03-31 公開日 1995-07-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Disulfide mutants of barnase. I: Changes in stability and structure assessed by biophysical methods and X-ray crystallography. J.Mol.Biol., 253, 1995
6ALW	The crystal structure of the Staphylococcus aureus Fatty acid Kinase (Fak) B1 protein loaded with 12-Methyl Myristic Acid (C15:0) to 1.63 Angstrom resolution 分子名称: (12R)-12-methyltetradecanoic acid, (12S)-12-methyltetradecanoic acid, EDD domain protein, ... 著者 Cuypers, M.G, Ericson, M, Subramanian, C, White, S.W, Rock, C.O. 登録日 2017-08-08 公開日 2018-11-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Acyl-chain selectivity and physiological roles ofStaphylococcus aureusfatty acid-binding proteins. J. Biol. Chem., 294, 2019
6OWH	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 92 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-05-09 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020

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