PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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2R64	Crystal structure of a 3-aminoindazole compound with CDK2 分子名称: Cell division protein kinase 2, N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE 著者 Lee, J, Choi, H, Kim, K.H, Jeong, S, Park, J.W, Baek, C.S, Lee, S.H. 登録日 2007-09-05 公開日 2008-09-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
2QDJ	Crystal structure of the Retinoblastoma protein N-domain provides insight into tumor suppression, ligand interaction and holoprotein architecture 分子名称: Retinoblastoma-associated protein 著者 Hassler, M, Mittnacht, S, Pearl, L.H. 登録日 2007-06-21 公開日 2008-01-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. Mol.Cell, 28, 2007
2R3O	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: (5-phenyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methanol, Cell division protein kinase 2 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3I	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3M	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: Cell division protein kinase 2, N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3F	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: 5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3Q	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: 3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide, Cell division protein kinase 2 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2QUQ	Crystal Structure of the Essential Inner Kinetochore Protein Cep3p 分子名称: Centromere DNA-binding protein complex CBF3 subunit B 著者 Bellizzi III, J.J, Harrison, S.C. 登録日 2007-08-06 公開日 2007-11-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the yeast inner kinetochore subunit Cep3p. Structure, 15, 2007
2R3R	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: 3-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2021-07-28 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2QRC	Crystal structure of the adenylate sensor from AMP-activated protein kinase in complex with ADP and AMP 分子名称: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Protein C1556.08c, ... 著者 Jin, X, Townley, R, Shapiro, L. 登録日 2007-07-28 公開日 2007-10-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Insight into AMPK Regulation: ADP Comes into Play. Structure, 15, 2007
2STW	SOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, RESTRAINED REGULARIZED MEAN STRUCTURE 分子名称: DNA (5'-D(*TP*CP*GP*AP*AP*CP*TP*TP*CP*CP*GP*GP*CP*TP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*AP*GP*CP*CP*GP*GP*AP*AP*GP*TP*TP*CP*GP*A)-3'), ETS1 著者 Clore, G.M, Werner, M.H, Gronenborn, A.M. 登録日 1996-08-05 公開日 1997-03-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Correction of the NMR structure of the ETS1/DNA complex. J.Biomol.NMR, 10, 1997
2Q5A	human Pin1 bound to L-PEPTIDE 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE, Five residue peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 著者 Noel, J.P, Zhang, Y. 登録日 2007-05-31 公開日 2007-06-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural basis for high-affinity peptide inhibition of human Pin1. Acs Chem.Biol., 2, 2007
2R3J	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: 3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3H	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: 3-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine, Cell division protein kinase 2 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2R3L	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor 分子名称: 3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine, Cell division protein kinase 2 著者 Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. 登録日 2007-08-29 公開日 2008-01-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89, 2008
2UZE	Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor 分子名称: 4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 著者 Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. 登録日 2007-04-27 公開日 2007-06-26 最終更新日 2019-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping. Bioorg.Med.Chem.Lett., 17, 2007
2R9Y	Structure of antiplasmin 分子名称: Alpha-2-antiplasmin 著者 Law, R.H.P, Sofian, T, Kan, W.T, Horvath, A.J, Hitchen, C.R, Langendorf, C.G, Buckle, A.M, Whisstock, J.C, Coughlin, P.B. 登録日 2007-09-14 公開日 2007-12-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin Blood, 111, 2008
2RFM	Structure of a Thermophilic Ankyrin Repeat Protein 分子名称: 1,3-BUTANEDIOL, CHLORIDE ION, GLYCEROL, ... 著者 Loew, C, Weininger, U, Neumann, P, Stubbs, M.T, Balbach, J. 登録日 2007-10-01 公開日 2008-03-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein Proc.Natl.Acad.Sci.Usa, 105, 2008
2RG3	Covalent complex structure of elastase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Leukocyte elastase 著者 Huang, W, Yamamoto, Y. 登録日 2007-10-02 公開日 2008-07-01 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives. J.Med.Chem., 51, 2008
2VEQ	Insights into kinetochore-DNA interactions from the structure of Cep3p 分子名称: BETA-MERCAPTOETHANOL, CACODYLATE ION, CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B 著者 Purvis, A, Singleton, M.R. 登録日 2007-10-26 公開日 2007-12-25 最終更新日 2017-07-12 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Insights Into Kinetochore-DNA Interactions from the Structure of Cep3Delta Embo Rep., 9, 2008
2STT	SOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, 25 STRUCTURES 分子名称: DNA (5'-D(*TP*CP*GP*AP*AP*CP*TP*TP*CP*CP*GP*GP*CP*TP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*AP*GP*CP*CP*GP*GP*AP*AP*GP*TP*TP*CP*GP*A)-3'), ETS1 著者 Clore, G.M, Werner, M.H, Gronenborn, A.M. 登録日 1996-08-05 公開日 1997-03-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Correction of the NMR structure of the ETS1/DNA complex. J.Biomol.NMR, 10, 1997
2RIM	Crystal structure of Rtt109 分子名称: Regulator of Ty1 transposition protein 109 著者 Yuan, Y.A. 登録日 2007-10-12 公開日 2008-09-02 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural insights into histone h3 lysine 56 acetylation by rtt109 Structure, 16, 2008
2V5X	Crystal structure of HDAC8-inhibitor complex 分子名称: (2R)-N~8~-HYDROXY-2-{[(5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETYL]AMINO}-N~1~-[2-(2-PHENYL-1H-INDOL-3-YL)ETHYL]OCTANEDIAMIDE, HISTONE DEACETYLASE 8, POTASSIUM ION, ... 著者 Di Marco, S, Vannini, A, Volpari, C, Gallinari, P, Jones, P, Mattu, M, Carfi, A, Defrancesco, R, Steinkuhler, C. 登録日 2007-07-10 公開日 2007-09-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Substrate Binding to Histone Deacetylases as Revealed by Crystal Structure of Hdac8-Substrate Complex Embo Rep., 8, 2007
2VI6	Crystal Structure of the Nanog Homeodomain 分子名称: HOMEOBOX PROTEIN NANOG 著者 Jauch, R, Ng, C.K.L, Saitakendu, K.S, Stevens, R.C, Kolatkar, P.R. 登録日 2007-11-28 公開日 2008-01-15 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure and DNA Binding of the Homeodomain of the Stem Cell Transcription Factor Nanog. J.Mol.Biol., 376, 2008
2VCG	Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17 分子名称: CHLORIDE ION, GLYCEROL, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ... 著者 Dickmanns, A, Strasser, A, Ficner, R. 登録日 2007-09-24 公開日 2008-01-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Phenylalanine-Containing Hydroxamic Acids as Selective Inhibitors of Class Iib Histone Deacetylases (Hdacs). Bioorg.Med.Chem., 16, 2008

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